Subscribe to RSS
DOI: 10.1055/s-0041-1731139
Recurrent Diabetic Ketoacidosis following Bariatric Surgery: The Role of Micronutrients
Abstract
We report a case of a 29-year-old woman admitted twice to our hospital with diabetic ketoacidosis (DKA) within 45 days following her bariatric surgery. The first admission required intensive care during her postoperative days after bariatric surgery. Subsequently, she continued to report high level of ketones on a daily basis. At her second admission, she presented with all three criteria of DKA. She was treated with a standard protocol for DKA, but ketones plasma level remained high despite significant improvement in pH and glycemic control. The administration of thiamine replacement was associated with normalization of the hyperketonemia. Thiamine deficiency can be associated with bariatric surgery and can lead to high ketone level in individuals with type 1 diabetes.
Publication History
Article published online:
28 June 2021
© 2021. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Hafeez S, Ahmed MH. Bariatric surgery as potential treatment for nonalcoholic fatty liver disease: a future treatment by choice or by chance?. J Obes 2013; 2013: 839275
- 2 Sjöström L, Narbro K, Sjöström CD. et al Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357 (08) 741-752
- 3 Sjöström L, Peltonen M, Jacobson P. et al Bariatric surgery and long-term cardiovascular events. JAMA 2012; 307 (01) 56-65
- 4 Park CH, Nam SJ, Choi HS. et al Korean Research Group for Endoscopic Management of Metabolic Disorder and Obesity. Comparative efficacy of bariatric surgery in the treatment of morbid obesity and diabetes mellitus: a systematic review and network meta-analysis. Obes Surg 2019; 29 (07) 2180-2190
- 5 Ichikawa H, Imoto H, Tanaka N. et al Efficacy of laparoscopic sleeve gastrectomy for patient with morbid obesity and type 1 diabetes mellitus: a case report. Surg Case Rep 2021; 7 (01) 7
- 6 Lange J, Königsrainer A. Malnutrition as a complication of bariatric surgery—a clear and present danger?. Visc Med 2019; 35 (05) 305-311
- 7 Anwar A, Ahmed Azmi M, Siddiqui JA, Panhwar G, Shaikh F, Ariff M. Thiamine level in type I and type II diabetes mellitus patients: a comparative study focusing on hematological and biochemical evaluations. Cureus 2020; 12 (05) e8027
- 8 Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: is there a potential to oppose gluco- and lipotoxicity by rational supplementation?. World J Diabetes 2014; 5 (03) 288-295
- 9 US National Library of Medicine. Thiamine as adjunctive therapy for diabetic ketoacidosis. available at: https://clinicaltrials.gov/ct2/show/NCT03717896. Published October 24, 2018. Accessed February 18, 2021.
- 10 Tang L, Alsulaim HA, Canner JK, Prokopowicz GP, Steele KE. Prevalence and predictors of postoperative thiamine deficiency after vertical sleeve gastrectomy. Surg Obes Relat Dis 2018; 14 (07) 943-950
- 11 Malone M. Recommended nutritional supplements for bariatric surgery patients. Ann Pharmacother 2008; 42 (12) 1851-1858
- 12 Saab R, El Khoury M, Farhat S. Wernicke’s encephalopathy three weeks after sleeve gastrectomy. Surg Obes Relat Dis 2014; 10 (05) 992-994
- 13 Zafar A. Wernicke’s encephalopathy following Roux en Y gastric bypass surgery. Saudi Med J 2015; 36 (12) 1493-1495
- 14 Arnadottir LO, Sigurbjornsson S, Gudbjartsson T. Beriberi 10 years after gastric bypass surgery—case report. Laeknabladid 2016; 102 (11) 497-499
- 15 Albaugh VL, Williams DB, Aher CV, Spann MD, English WJ. Prevalence of thiamine deficiency is significant in patients undergoing primary bariatric surgery. Surg Obes Relat Dis 2020; S1550-7289 (20) 30706-1
- 16 Carrodeguas L, Kaidar-Person O, Szomstein S, Antozzi P, Rosenthal R. Preoperative thiamine deficiency in obese population undergoing laparoscopic bariatric surgery. Surg Obes Relat Dis 2005; 1 (06) 517-522 discussion 522