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CC BY-NC-ND 4.0 · J Lab Physicians 2021; 13(02): 162-168
DOI: 10.1055/s-0041-1729485
Original Article

Seroprevalence of Transfusion-Transmitted Infections among Voluntary and Replacement Blood Donors at the Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan

Noore Saba
1   Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan
,
Jamal Abdul Nasir
1   Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan
,
Usman Waheed
2   Islamabad Blood Transfusion Authority, Ministry of National Health Services, Government of Pakistan, Pakistan
,
Sidra Aslam
3   Department of Pathology, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, Azad Jammu and Kashmir, Pakistan
,
Iqbal Mohammad
1   Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan
,
Akhlaaq Wazeer
4   Department of Biotechnology, Mirpur University of Science and Technology, Mirpur, Azad Jammu and Kashmir, Pakistan
,
Saeed Ahmed
5   Department of Blood Bank, Prince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia
,
Muhammad Nisar
1   Department of Health, Peshawar Regional Blood Centre, Khyber Pakhtunkhwa, Pakistan
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Abstract

Introduction Blood transfusion is linked to several risks, most notably the transmission of transfusion-transmitted infections (TTIs), including hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis, and malaria. The risk posed by these blood-borne infectious agents is high in developing countries, including Pakistan. This fact stresses the need for regular surveillance of TTIs. Therefore, the present study was undertaken to assess the seroprevalence of TTIs at a regional blood center.

Material and Methods This was a retrospective 4-year descriptive study undertaken at the Regional Blood Centre in Peshawar, Khyber Pakhtunkhwa Province of Pakistan, on the blood donor data from June 2016 to May 2020. A total of 41,817 donors donated blood during the study period and were screened for HBV, HCV, HIV, syphilis, and malaria. To ensure donor privacy, donors were identified via codes and no personal information was available. The data were extracted from the ZAAVIA blood transfusion information system database.

Results The study included a total of 41,817 donors—41,493 (99.22%) males and 324 (0.78%) females. Of them, 22,343 (53.43%) were voluntary donors while 19,474 (46.57%) were replacement donors. An overall TTI prevalence rate of 4.61% was found. The TTI prevalence rate in voluntary donors was 3.90% while 5.42% in replacement donors. The overall prevalence of HBV, HCV, HIV, syphilis, and malaria was 1.95, 1.38, 0.23, 0.91, and 0.14%, respectively.

Conclusion The current study documented a high prevalence (1,929 out of 41,817, 4.61%) of TTIs, especially in replacement donors (1,057 out of 19,474, 5.42%), and low participation of female donors. The recommendations include the promotion of voluntary blood donors, enrolment of female blood donors, and screening of donated blood through highly sensitive screening assay (i.e., nucleic acid testing).

Keywords

transfusion - blood - donors - infection - seroprevalence


Publikationsverlauf

Artikel online veröffentlicht:
26. Mai 2021

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