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DOI: 10.1055/s-0041-1729129
3D Printing Applications for Radiology: An Overview
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Abstract
Three-dimensional (3D) printing technologies are part of additive manufacturing processes and are used to manufacture a 3D physical model from a digital computer-aided design model as per the required shape and size. These technologies are now used for advanced radiology applications by providing all information through 3D physical model. It provides innovation in radiology for clinical applications, treatment planning, procedural simulation, medical and patient education. Radiological advancements have been made in diagnosis and communication through medical digital imaging techniques like computed tomography, magnetic resonance imaging. These images are converted into Digital Imaging and Communications in Medicine in Standard Triangulate Language file format, easily printable in 3D printing technologies. This 3D model provides in-depth information about pathologic and anatomic states. It is useful to create new opportunities related to patient care. This article discusses the potential of 3D printing technology in radiology. The steps involved in 3D printing for radiology are discussed diagrammatically, and finally identified 12 significant applications of 3D printing technology for radiology with a brief description. A radiologist can incorporate this technology to fulfil different challenges such as training, planning, guidelines, and better communications.
Publication History
Article published online:
01 June 2021
© 2021. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Itagaki MW. Using 3D printed models for planning and guidance during endovascular intervention: a technical advance. Diagn Interv Radiol 2015; 21 (04) 338-341
- 2 Jahnke P, Schwarz FB, Ziegert M. et al. A radiopaque 3D printed, anthropomorphic phantom for simulation of CT-guided procedures. Eur Radiol 2018; 28 (11) 4818-4823
- 3 Yang DH, Kang JW, Kim N, Song JK, Lee JW, Lim TH. Myocardial 3-dimensional printing for septal myectomy guidance in a patient with obstructive hypertrophic cardiomyopathy. Circulation 2015; 132 (04) 300-301
- 4 Jahnke P, Schwarz S, Ziegert M, Schwarz FB, Hamm B, Scheel M. Paper-based 3D printing of anthropomorphic CT phantoms: feasibility of two construction techniques. Eur Radiol 2019; 29 (03) 1384-1390
- 5 Ogden KM, Morabito KE, Depew PK. 3D printed testing aids for radiographic quality control. J Appl Clin Med Phys 2019; 20 (05) 127-134
- 6 Christensen A, Rybicki FJ. Maintaining safety and efficacy for 3D printing in medicine. 3D Print Med 2017; 3 (01) 1
- 7 Mihić MS, Pavelić L, Kortmiš MV, Šiško J, Maltar-Strmečki N, Prlić I. 3D-printed eye lens dosemeter holder for use in interventional radiology and interventional cardiology. Radiat Meas 2020; 135: 106385
- 8 Javaid M, Haleem A. Additive manufacturing applications in medical cases: a literature based review. Alex J Med 2018; 54: 411-422
- 9 Weadock WJ, Heisel CJ, Kahana A, Kim J. Use of 3D printed models to create molds for shaping implants for surgical repair of orbital fractures. Acad Radiol 2020; 27 (04) 536-542
- 10 Newcomb TL, Bruhn AM, Giles B, Garcia HM, Diawara N. Testing a novel 3D printed radiographic imaging device for use in forensic odontology. J Forensic Sci 2017; 62 (01) 223-228
- 11 Tack P, Victor J, Gemmel P, Annemans L. 3D-printing techniques in a medical setting: a systematic literature review. Biomed Eng Online 2016; 15 (01) 115
- 12 George E, Barile M, Tang A. et al. Utility and reproducibility of 3-dimensional printed models in pre-operative planning of complex thoracic tumors. J Surg Oncol 2017; 116 (03) 407-415
- 13 Mitsouras D, Liacouras P, Imanzadeh A. et al. Medical 3D printing for the radiologist. Radiographics 2015; 35 (07) 1965-1988
- 14 Squelch A. 3D printing and medical imaging. J Med Radiat Sci 2018; 65 (03) 171-172
- 15 Kim GB, Lee S, Kim H. et al. Three-dimensional printing: basic principles and applications in medicine and radiology. Korean J Radiol 2016; 17 (02) 182-197
- 16 Massat III MB. Printing is bridging the gap between radiology and surgery. Appl Radiol 2020; 49: 38-41
- 17 Ballard DH, Mills P, Duszak Jr R, Weisman JA, Rybicki FJ, Woodard PK. Medical 3D printing cost-savings in orthopedic and maxillofacial surgery: cost analysis of operating room time saved with 3D printed anatomic models and surgical guides. Acad Radiol 2020; 27 (08) 1103-1113
- 18 Takao H, Amemiya S, Shibata E, Ohtomo K. 3D printing of preoperative simulation models of a splenic artery aneurysm: precision and accuracy. Acad Radiol 2017; 24 (05) 650-653
- 19 Murphy SV, De Coppi P, Atala A. Opportunities and challenges of translational 3D bioprinting. Nat Biomed Eng 2020; 4 (04) 370-380
- 20 Matai I, Kaur G, Seyedsalehi A, McClinton A, Laurencin CT. Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials 2020; 226: 119536
- 21 Goudie C, Kinnin J, Bartellas M, Gullipalli R, Dubrowski A. The use of 3D printed vasculature for simulation-based medical education within interventional radiology. Cureus 2019; 11 (04) e4381
- 22 Vukicevic M, Mosadegh B, Min JK, Little SH. Cardiac 3D printing and its future directions. JACC Cardiovasc Imaging 2017; 10 (02) 171-184
- 23 Solc J, Vrba T, Burianova L. Tissue-equivalence of 3D-printed plastics for medical phantoms in radiology. J Instrum 2018; 13: P09018
- 24 Michalski MH, Ross JS. The shape of things to come: 3D printing in medicine. JAMA 2014; 312 (21) 2213-2214
- 25 Veneziani GR, Corrêa EL, Potiens MPA, Campos LL. Attenuation coefficient determination of printed ABS and PLA samples in diagnostic radiology standard beams. J Phys Conf Ser 2016; 733: 012088
- 26 Cohen A, Laviv A, Berman P, Nashef R, Abu-Tair J. Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108 (05) 661-666
- 27 Friedman T, Michalski M, Goodman TR, Brown JE. 3D printing from diagnostic images: a radiologist’s primer with an emphasis on musculoskeletal imaging-putting the 3D printing of pathology into the hands of every physician. Skeletal Radiol 2016; 45 (03) 307-321
- 28 Ballard DH, Trace AP, Ali S. et al. Clinical applications of 3D printing: primer for radiologists. Acad Radiol 2018; 25 (01) 52-65
- 29 Javan R, Herrin D, Tangestanipoor A. Understanding spatially complex segmental and branch anatomy using 3D printing: liver, lung, prostate, coronary arteries, and circle of Willis. Acad Radiol 2016; 23 (09) 1183-1189
- 30 Giannopoulos AA, Mitsouras D, Yoo SJ, Liu PP, Chatzizisis YS, Rybicki FJ. Applications of 3D printing in cardiovascular diseases. Nat Rev Cardiol 2016; 13 (12) 701-718
- 31 Andrade MAB, Fin APC, de Oliveira Alves C, Soares FAP, Savi MBB, da Penha Albuquerque Potiens M. Visual impact of infill percentages for 3D printed radiologic simulators.. Braz J Radiat Sci 2020; 8
- 32 Murakami T, Tajika Y, Ueno H. et al. An integrated teaching method of gross anatomy and computed tomography radiology. Anat Sci Educ 2014; 7 (06) 438-449
- 33 Aimar A, Palermo A, Innocenti B. The role of 3D printing in medical applications: a state of the art. J Healthc Eng 2019; 2019: 5340616
- 34 Chang D, Tummala S, Sotero D. et al. Three-dimensional printing for procedure rehearsal/simulation/planning in interventional radiology. Tech Vasc Interv Radiol 2019; 22 (01) 14-20
- 35 Haleem A, Javaid M, Khan RH, Suman R. 3D printing applications in bone tissue engineering. J Clin Orthop Trauma 2020; 11 (Suppl. 01) S118-S124
- 36 George E, Liacouras P, Rybicki FJ, Mitsouras D. Measuring and establishing the accuracy and reproducibility of 3D printed medical models. Radiographics 2017; 37 (05) 1424-1450
- 37 Jammalamadaka U, Tappa K. Recent advances in biomaterials for 3D printing and tissue engineering. J Funct Biomater 2018; 9 (01) 22
- 38 Javaid M, Haleem A. 3D printed tissue and organ using additive manufacturing: an overview. Clin Epidemiol Glob Health 2020; 8: 586-594
- 39 McMenamin PG, Quayle MR, McHenry CR, Adams JW. The production of anatomical teaching resources using three-dimensional (3D) printing technology. Anat Sci Educ 2014; 7 (06) 479-486
- 40 Flanagan ST, Ballard DH. 3D printed face shields: a community response to the COVID-19 global pandemic. Acad Radiol 2020; 27 (06) 905-906
- 41 Haleem A, Javaid M. Role of CT and MRI in the design and development of orthopaedic model using additive manufacturing. J Clin Orthop Trauma 2018; 9 (03) 213-217
- 42 Marconi S, Pugliese L, Botti M. et al. Value of 3D printing for the comprehension of surgical anatomy. Surg Endosc 2017; 31 (10) 4102-4110
- 43 Wang X, Jiang M, Zhou Z, Gou J, Hui D. 3D printing of polymer matrix composites: a review and prospective. Compos B Eng 2017; 110: 442-458
- 44 Giannopoulos AA, Chepelev L, Sheikh A. et al. 3D printed ventricular septal defect patch: a primer for the 2015 Radiological Society of North America (RSNA) hands-on course in 3D printing. 3D Print Med 2015; 1 (01) 3
- 45 Javaid M, Haleem A. Current status and challenges of Additive manufacturing in orthopaedics: An overview. J Clin Orthop Trauma 2019; 10 (02) 380-386
- 46 Ripley B, Levin D, Kelil T. et al. 3D printing from MRI data: harnessing strengths and minimizing weaknesses. J Magn Reson Imaging 2017; 45 (03) 635-645
- 47 Sheikh A, Chepelev L, Christensen AM, Mitsouras D, Schwarz BA, Rybicki FJ. Beginning and developing a radiology-based in-hospital 3D printing lab In: Rybicki F, Grant G, eds. 3D Printing in Medicine.. Cham: Springer 2017; 35-41
- 48 Succi MD, Uppot RN, Gee MS, McLoud TC, Brink JA. Medically engineered solutions in health care: a technology incubator and design-thinking curriculum for radiology trainees. J Am Coll Radiol 2018; 15 (06) 892-896
- 49 Anwari V. 3D printing in clinical radiology: the MRT experience. J Med Imaging Radiat Sci 2019; 50: S1
- 50 Javaid M, Haleem A. Current status and applications of additive manufacturing in dentistry: a literature-based review. J Oral Biol Craniofac Res 2019; 9 (03) 179-185
- 51 Eley KA, Watt-Smith SR, Golding SJ. “Black Bone” MRI: a novel imaging technique for 3D printing. Dentomaxillofac Radiol 2017; 46 (03) 20160407
- 52 Haleem A, Javaid M. 3D printed medical parts with different materials using additive manufacturing. Clin Epidemiol Glob Health 2020; 8: 215-223
- 53 Chepelev L, Wake N, Ryan J. et al. RSNA Special Interest Group for 3D Printing. Radiological Society of North America (RSNA) 3D printing Special Interest Group (SIG): guidelines for medical 3D printing and appropriateness for clinical scenarios. 3D Print Med 2018; 4 (01) 11
- 54 Iannessi A, Marcy PY, Clatz O, Bertrand AS, Sugimoto M. A review of existing and potential computer user interfaces for modern radiology. Insights Imaging 2018; 9 (04) 599-609
- 55 Huang YH, Patel DC, Wagner C, Goettl C. Cost-effective 3D printing of custom vascular models in vascular and interventional radiology. Print Med 2018; 2: 7-14
- 56 Marro A, Bandukwala T, Mak W. Three-dimensional printing and medical imaging: a review of the methods and applications. Curr Probl Diagn Radiol 2016; 45 (01) 2-9
- 57 Alssabbagh M, Abdulmanap M, Zainon R. Evaluation of 3D printing materials for fabrication of a novel multi-functional 3D thyroid phantom for medical dosimetry and image quality. Radiat Phys Chem 2017; 135: 106-112
- 58 Haleem A, Javaid M. 3D scanning applications in medical field: a literature-based review. Clin Epidemiol Glob Health 2019; 7: 199-210
- 59 Hodgdon T, Danrad R, Patel MJ. et al. Logistics of three-dimensional printing: Primer for radiologists. Acad Radiol 2018; 25 (01) 40-51
- 60 Javaid M, Haleem A. Additive manufacturing applications in orthopaedics: a review. J Clin Orthop Trauma 2018; 9 (03) 202-206
- 61 Wake N, Chandarana H, Huang WC, Taneja SS, Rosenkrantz AB. Application of anatomically accurate, patient-specific 3D printed models from MRI data in urological oncology. Clin Radiol 2016; 71 (06) 610-614
- 62 Trace AP, Ortiz D, Deal A. et al. Radiology’s emerging role in 3-D printing applications in health care. J Am Coll Radiol 2016; 13 (07) 856-862.e4
- 63 Rengier F, Mehndiratta A, von Tengg-Kobligk H. et al. 3D printing based on imaging data: review of medical applications. Int J CARS 2010; 5 (04) 335-341
- 64 Munuera J, Barber I, Ayats M, et al. Diagnostic challenges in pediatric radiology: How 3D planning and printing could improve the management. European Congress of Radiology; 2020
- 65 Wake N, Bjurlin MA, Rostami P, Chandarana H, Huang WC. Three-dimensional printing and augmented reality: enhanced precision for robotic assisted partial nephrectomy. Urology 2018; 116: 227-228
- 66 Nikitichev DI, Patel P, Avery J. et al. Patient-specific 3D Printed Models for Education, Research and Surgical Simulation. Print 2018
- 67 van Hoek J, Huber A, Leichtle A. et al. A survey on the future of radiology among radiologists, medical students and surgeons: students and surgeons tend to be more skeptical about artificial intelligence and radiologists may fear that other disciplines take over. Eur J Radiol 2019; 121: 108742
- 68 Mitsouras D, Liacouras PC, Wake N, Rybicki FJ. RadioGraphics update: medical 3D printing for the radiologist. Radiographics 2020; 40 (04) E21-E23
- 69 Weisman JA, Ballard DH, Jammalamadaka U. et al. 3D printed antibiotic and chemotherapeutic eluting catheters for potential use in interventional radiology: in vitro proof of concept study. Acad Radiol 2019; 26 (02) 270-274
- 70 Uppot RN, Laguna B, McCarthy CJ. et al. Implementing virtual and augmented reality tools for radiology education and training, communication, and clinical care. Radiology 2019; 291 (03) 570-580
- 71 Martín Noguerol T, Paulano-Godino F, Martín-Valdivia MT, Menias CO, Luna A. Strengths, weaknesses, opportunities, and threats analysis of artificial intelligence and machine learning applications in radiology. J Am Coll Radiol 2019; 16 (9 Pt B) 1239-1247
- 72 Van Der Klift F, Koga Y, Todoroki A, Ueda M, Hirano Y, Matsuzaki R. 3D printing of continuous carbon fibre reinforced thermo-plastic (CFRTP) tensile test specimens. Open J Compos Mater 2016; 6: 18
- 73 Haleem A, Javaid M. Polyether ether ketone (PEEK) and its manufacturing of customised 3D printed dentistry parts using additive manufacturing. Clin Epidemiol Glob Health 2019; 7: 654-660
- 74 Tam MD, Laycock SD, Brown JR, Jakeways M. 3D printing of an aortic aneurysm to facilitate decision making and device selection for endovascular aneurysm repair in complex neck anatomy. J Endovasc Ther 2013; 20 (06) 863-867
- 75 Tappa K, Jammalamadaka U. Novel biomaterials used in medical 3D printing techniques. J Funct Biomater 2018; 9 (01) 17
- 76 AbouHashem Y, Dayal M, Savanah S, Štrkalj G. The application of 3D printing in anatomy education. Med Educ Online 2015; 20: 29847 DOI: 10.3402/meo.v20.29847.
- 77 Ballard DH, Wake N, Witowski J, Rybicki FJ, Sheikh A. RSNA Special Interest Group for 3D Printing Abdominal, Hepatobiliary, and Gastrointestinal Conditions Voting Group. Radiological Society of North America (RSNA) 3D Printing Special Interest Group (SIG) clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: abdominal, hepatobiliary, and gastrointestinal conditions. 3D Print Med 2020; 6 (01) 13
- 78 Ebert LC, Thali MJ, Ross S. Getting in touch–3D printing in forensic imaging. Forensic Sci Int 2011; 211 (1-3) e1-e6
- 79 Bundy JJ, Weadock WJ, Chick JFB. et al. Three-dimensional printing facilitates creation of a biliary endoscopy phantom for interventional radiology-operated endoscopy training. Curr Probl Diagn Radiol 2019; 48 (05) 456-461
- 80 Starosolski ZA, Kan JH, Rosenfeld SD, Krishnamurthy R, Annapragada A. Application of 3-D printing (rapid prototyping) for creating physical models of pediatric orthopedic disorders. Pediatr Radiol 2014; 44 (02) 216-221
- 81 Perica E, Sun Z. Patient-specific three-dimensional printing for pre-surgical planning in hepatocellular carcinoma treatment. Quant Imaging Med Surg 2017; 7 (06) 668-677
- 82 Leng S, McGee K, Morris J. et al. Anatomic modeling using 3D printing: quality assurance and optimization. 3D Print Med 2017; 3 (01) 6
- 83 Cho YI. Feasibility of the 3D printing materials for radiation dose reduction in interventional radiology. J Radiol Sci Technol 2020; 43: 169-176
- 84 Pugliese L, Marconi S, Negrello E. et al. The clinical use of 3D printing in surgery. Updates Surg 2018; 70 (03) 381-388