PDF herunterladen
CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2022; 11(02): 118-122
DOI: 10.1055/s-0041-1726609
Review Article

Analysis of Factors Influencing the Long-term Outcome in Primary Spinal Cord Tumors: Review of Literature

Uddanapalli Srinivasan 
1   Department of Neurosurgery, Sri Balaji Hospital, Guindy, Chennai, Tamil Nadu, India
,
Natarajan Raghunathan
2   Department of Neurosurgery, MIOT Hospitals, Manapakkam, Chennai, Tamil Nadu, India
› Institutsangaben
› Weitere Informationen
   Lizenzen und Reprints

Abstract

Introduction Primary spinal cord tumors are amenable to total surgical excision but the outcomes are still diverse.

Objective The purpose of this study is to identify the significant factors which influence the long-term outcome of spinal cord tumors.

Materials and Methods A total of 84 consecutive spinal cord tumor patients who underwent microsurgical excision during April 2003 to 2014 were retrospectively studied. Patients operated after April 2014 were not considered. Ten factors were taken and correlated with the outcome. Multiple regression analysis was used. Patients were periodically evaluated at 1, 6 months, 1, 2, and 5 years. In 72 cases, postoperative MRI scans were performed. The follow-up period ranged between 5 to 15 years.

Results In our study, we had 64 extramedullary tumors and 21 intramedullary tumors with varied pathology. Axial location of the tumour (20.294/0.000), extent of the resection of the tumour (13.827/0.001), preoperative Nurick grade (11.349/0.023), and location of the tumour in the spine with respect to vertebral segments (8.151/0.017) were significant predictive factors. We had good outcomes in 65 cases and poor outcomes in 19 cases.

Conclusion Our results show location of the tumor with respect to axial plane and vertebral segments were the main contributing factors. They influence the extent of excision of the spinal cord tumor. Preoperative neurological status is the fourth factor which independently determines the long-term outcome. It is one of the few papers where patients have been followed-up for a long period ranging from 5 to 15 years.

Keywords

spinal cord tumors - extramedullary tumor - intramedullary tumor


Publikationsverlauf

Artikel online veröffentlicht:
24. November 2021

© 2021. Neurological Surgeons’ Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Chamberlain MC, Tredway TL. Adult primary intradural spinal cord tumors: a review. Curr Neurol Neurosci Rep 2011; 11 (03) 320-328
    CrossrefPubMedGoogle Scholar
  • 2 Traul DE, Shaffrey ME, Schiff D. Part I: spinal-cord neoplasms-intradural neoplasms. Lancet. Oncology.thelancet.com 2007; 8 (01) 35-45
    CrossrefPubMedGoogle Scholar
  • 3 Nurick S. The pathogenesis of the spinal cord disorder associated with cervical spondylosis. Brain 1972; 95 (01) 87-100
    CrossrefPubMedGoogle Scholar
  • 4 Maurya P, Singh K, Sharma V. C1 and C2 nerve sheath tumors: analysis of 32 cases. Neurol India 2009; 57 (01) 31-35
    CrossrefPubMedGoogle Scholar
  • 5 Tanmoy KM, Shyamal CB, Devi P Prasad, Piyush K, Bharat G, Anil N. Spinal meningiomas: clinic-radiological factors predicting the recurrence and functional outcome. Neurosurg Focus 2016; 41 E6 1-10
    PubMedGoogle Scholar
  • 6 Mehta AI, Adogwa O, Karikari IO. et al Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors: a 10-year single-institutional experience. J Neurosurg Spine 2013; 19 (06) 701-707
    CrossrefPubMedGoogle Scholar
  • 7 Jacob G. Spinal meningiomas. Personal experience and review of literature. Romanian Neurosurgery 2014; 21: 147-161
    CrossrefPubMedGoogle Scholar
  • 8 Singh PR, Pandey TK, Ahmad F, Chhabra DK. A prospective observational study of clinical outcome of operated patients of intradural extramedullary spinal cord tumor in our tertiary care center. Romanian Neurosurgery 2018; 32: 632-640
    PubMedGoogle Scholar
  • 9 Chandy MJ, Babu S. Management of intramedullary spinal cord tumors: review of 68 patients. Neurol India 1999; 47 (03) 224-228
    PubMedGoogle Scholar
  • 10 Kaner T, Sasani M, Oktenoglu T, Solmaz B, Sarloglu AC, Ozer AF. Clinical analysis of 21 cases of spinal cord ependymoma: positive clinical results of gross total resection. J Korean Neurosurg Soc 2010; 47 (02) 102-106
    CrossrefPubMedGoogle Scholar
  • 11 Aghayev K, Vrionis F, Chamberlain MC. Adult intradural primary spinal cord tumors. J Natl Compr Canc Netw 2011; 9 (04) 434-447
    CrossrefPubMedGoogle Scholar
  • 12 Hufana V, Tan JSH, Tan KK. Microsurgical treatment for spinal tumors. Singapore Med J 2005; 46 (02) 74-77
    PubMedGoogle Scholar
  • 13 Jenkinson MD, Simpson C, Nicholas RS, Miles J, Findlay GFG, Pigott TJD. Outcome predictors and complications in the management of intradural spinal tumors. Eur Spine J 2006; 15 (02) 203-210
    CrossrefPubMedGoogle Scholar
  • 14 Yamane K, Takigawa T, Tanaka M, Osaki S, Sugimoto Y, Ozaki T. Factors predicting clinical impairment after surgery for cervical spinal schwannoma. Acta Med Okayama 2013; 67 (06) 343-349
    PubMedGoogle Scholar
  • 15 Stawicki SP, Guarnaschelli JJ. Intradural extramedullary spinal cord tumors: A retrospective study of tumor types, locations, and surgical outcomes. The Internet Journal of Neurosurgery 2006; 4: 1-6
    PubMedGoogle Scholar
  • 16 Chang UK, Choe WJ, Chung SK, Chung CK, Kim HJ. Surgical outcome and prognostic factors of spinal intramedullary ependymomas in adults. J Neurooncol 2002; 57 (02) 133-139
    CrossrefPubMedGoogle Scholar