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Am J Perinatol 2022; 39(12): 1348-1353
DOI: 10.1055/s-0040-1722597
Original Article

Neurodevelopmental Outcome in Very Low Birth Weight Infants Exposed to Donor Milk

Kousiki Patra 
1   Department of Pediatrics, Rush University Children's Hospital, Chicago, Illinois
,
Michelle M. Greene
1   Department of Pediatrics, Rush University Children's Hospital, Chicago, Illinois
,
Grace Tobin
2   Department of Neurology, University of Minnesota, Minneapolis, Minnesota
,
Gina Casini
3   Department of Pediatrics, Baylor College of Medicine, Houston, Texas
,
Anita L. Esquerra-Zwiers
4   Department of Nursing, Hope College, Holland, Michigan
,
Paula P. Meier
1   Department of Pediatrics, Rush University Children's Hospital, Chicago, Illinois
,
Aloka L. Patel
1   Department of Pediatrics, Rush University Children's Hospital, Chicago, Illinois
› Author Affiliations Funding This study received funds from National Institute of Health, grant no.: R01 NR010009; Rush University Pilot Program Grant 2011; and Rush University Dean's Office Summer Research Fellowship.
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Erratum: Neurodevelopmental Outcome in Very Low Birth Weight Infants Exposed to Donor MilkAm J Perinatol 2022; 39(12): e1-e1
DOI: 10.1055/s-0041-1722896

Abstract

Objective This study was aimed to evaluate the impact of donor milk (DM) received in the first 28 days of life (DOL) on neurodevelopmental (ND) outcome at 20-months corrected age (CA) in very low birth weight (VLBW) infants.

Study Design A total of 84 infants born in 2011 to 2012 who received only mother's own milk (MOM) and/or preterm formula (PF) was compared with 69 infants born in 2013 to 2014 who received MOM and/or DM. Daily enteral intake of MOM, DM, and PF was collected through 28 DOL. ND outcomes were assessed with the Bayley-III. Multiple regression analyses adjusted for the effect of social and neonatal risk factors alongside era of birth on ND outcome.

Results Infants exposed to DM were born to older mothers (p < 0.01) and had higher incidence of severe brain injury (p = 0.013). Although DM group infants received first feed at earlier DOL (p < 0.001), there were no differences in MOM intake at DOL 14 or 28 between the two groups. In regression analyses, DM group did not predict 20-month ND outcome.

Conclusion There were no differences in ND outcome between infants born before and after the introduction of DM. This may have been due to the similar percent of MOM at DOL 14 and 28 in the two eras.

Key Points

  • Donor milk use is increasing in VLBW infant. The impact of donor milk on neurodevelopment is unclear.

  • Provision of mother's own milk was high at days of life 14 and 28 for both groups of infants.

  • Donor milk was not associated with improved neurodevelopmental outcome.

Keywords

donor milk - neurodevelopmental outcome - VLBW infant


Publication History

Received: 20 April 2020

Accepted: 02 December 2020

Article published online:
06 January 2021

© 2021. Thieme. All rights reserved.

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