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DOI: 10.1055/s-0040-1721712
Pregnancy Outcomes Associated with Introduction of Early Diabetes Screening Guidelines
Funding L.M.Y. was supported by the NICHD K12 HD050121–11 at the time of the study. Research reported in this publication was supported, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, grant number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.![](https://www.thieme-connect.de/media/ajp/202211/lookinside/thumbnails/10-1055-s-0040-1721712_200749-1.jpg)
Abstract
Objective The study aimed to evaluate perinatal outcomes associated with introduction of and adherence to early diabetes screening guidelines.
Study Design Retrospective cohort study of all women who received prenatal care at a single, high-volume tertiary care center before (“preguidelines”) and after (“postguidelines”) American College of Obstetrics and Gynecology guidelines for early pregnancy diabetes screening for women at high risk for diabetes. Women with known pregestational diabetes, late entry to prenatal care, a fetus with a known anomaly, or multiple gestation were excluded. Multivariable linear and logistic regression models were constructed to compare maternal and neonatal outcomes between women in the preguidelines cohort to those in the postguidelines cohort. Similarly, adherence to screening guidelines was assessed, and among all women who were eligible for early diabetes screening, multivariable linear, and logistic models were created to compare outcomes between those women who were screened early to those who were not.
Results Of the 2,069 women eligible for analysis, 64.6% (n = 1,337) were in the postguideline cohort. Women in the postguideline cohort were older, less likely to have a history of smoking, and more likely to be non-Hispanic white. On multivariable analysis, women in the postguideline cohort had significantly less gestational weight gain (aβ = −2.3; 95% confidence interval [CI]: −3.4 to −1.1), but a higher odds of 5-minute Apgar's score of <7 (adjusted odds ratio: 2.51; 95% CI: 1.11–5.66). Of 461 women who met ACOG early diabetes screening criteria, 58.7% (n = 270) were screened appropriately. Adherence to screening was associated with parity, race, insurance, and BMI. On multivariable analysis, there were no significant differences in neonatal outcomes between women meeting early screening criteria who were screened early and those who were not.
Conclusion Introduction of early diabetes screening guidelines was associated with a significant decrease in gestational weight gain, but did not improve neonatal outcomes.
Key Points
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Introduction of early diabetes screening guideline did not improve rate of early screening.
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Detection and treatment of gestational diabetes may not improve perinatal outcomes.
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Early screening guidelines was associated with decreased gestational weight.
Note
The study was presented as a poster at the 2019 Society for Maternal Fetal Medicine 39th Annual Meeting, Las Vegas, NV, February 2019.
Publication History
Received: 20 August 2020
Accepted: 04 November 2020
Article published online:
22 December 2020
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