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DOI: 10.1055/s-0040-1720406
Enantioselective Intermolecular Murai-Type Alkene Hydroarylation Reactions
We thank the European Research Council [Grant 639594 (CatHet) and Grant 863799 (ChiCC)], the University of Bristol, and the University of Liverpool for funding. We also thank the Bristol Chemical Synthesis Centre for Doctoral Training, funded by the EPSRC (EP/L015366/1), and AstraZeneca for a studentship (to T.P.A.).
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Abstract
Strategies that enable the efficient assembly of complex building blocks from feedstock chemicals are of paramount importance to synthetic chemistry. Building upon the pioneering work of Murai and co-workers in 1993, C–H-activation-based enantioselective hydroarylations of alkenes offer a particularly promising framework for the step- and atom-economical installation of benzylic stereocenters. This short review presents recent intermolecular enantioselective Murai-type alkene hydroarylation methodologies and the mechanisms by which they proceed.
1 Introduction
2 Enantioselective Hydroarylation Reactions of Strained Bicyclic Alkenes
3 Enantioselective Hydroarylation Reactions of Electron-Rich Acyclic Alkenes
4 Enantioselective Hydroarylation Reactions of Electron-Poor Acyclic Alkenes
5 Enantioselective Hydroarylation Reactions of Minimally Polarized Acyclic Alkenes
6 Conclusion and Outlook
Publication History
Received: 15 March 2021
Accepted after revision: 15 April 2021
Article published online:
25 May 2021
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