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CC BY-NC-ND 4.0 · SynOpen 2022; 06(03): 141-157
DOI: 10.1055/s-0040-1720032
DOI: 10.1055/s-0040-1720032
review
Synthetic Approaches to Diospongins: A Two Decade Journey
The author Dr. Krishnaji acknowledges CHRIST (Deemed to be University) for funding though the Major Research Project (MRP # MRPDSC-1723).
Abstract
Tetrahydropyran units having multiple stereogenic centers serve as excellent building blocks for various active pharmaceutical ingredients (APIs). In particular, the presence of the unique molecular architecture of the trisubstituted tetrahydropyran (THP) unit in diospongins enhances their biological activity due to multiple stereogenic centers and has attracted attention from the synthetic community over the last two decades. In this review, we discuss synthetic approaches to chiral and racemic forms of diospongins during the period 2006–2020 in chronological order.
Key words
diospongins - diarylheptanoids - tetrahydropyran - cross-metathesis - hetero-Diels–Alder reaction - asymmetric allylation - enzyme resolution - oxa-Michael addition - Prins cyclizationPublication History
Received: 09 June 2022
Accepted after revision: 20 June 2022
Article published online:
14 July 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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