Metal-Free Thiolation and Hydroxylation of CF₃-Substituted Alkenes: A Practical Method to Synthesize Trifluoromethyl Tertiary Alcohols

Abstract

A novel and practical method to synthesize trifluoromethyl tertiary alcohols has been developed. Under mild reaction conditions, the present reaction could be compatible with a wide range of functional groups. Moreover, the performance of gram-scale reaction and further transformations illustrated the good potential utility of the present chemistry. Furthermore, the radical process of this reaction has been proved by mechanistic studies.

Key words

alcohols - fluorine - green chemistry - radical reaction - regio­selectivity

Publication History

Received: 17 February 2022

Accepted after revision: 16 March 2022

Article published online:
28 April 2022

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