a
Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira str., 620002, Ekaterinburg, Russian Federation
b
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy str., 620108, Ekaterinburg, Russian Federation
a
Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira str., 620002, Ekaterinburg, Russian Federation
b
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy str., 620108, Ekaterinburg, Russian Federation
a
Department of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira str., 620002, Ekaterinburg, Russian Federation
b
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 S. Kovalevskoy str., 620108, Ekaterinburg, Russian Federation
,
Irina V. Guzhova
c
Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky av., 194064, St-Petersburg, Russian Federation
,
Elena R. Mikhaylova
c
Institute of Cytology of the Russian Academy of Sciences, 4 Tikhoretsky av., 194064, St-Petersburg, Russian Federation
,
Andrey P. Antonchick
d
Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University, Clifton Lane, NG11 8NS, Nottingham, UK
› InstitutsangabenThe research was supported by Ministry of Science and Higher Education of Russia, Research Project N 075-15-2020-795, local identifier 13.1902.21.0027.
Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation.
3a
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8a
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8b
Zhang B,
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Mol. Neurodegener. 2018; 13: 59
26 CCDC 1841576 (8b), 1841579 (8e), 1841577 (8h), and 1841578 (8m) contain the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures
