Skeletal Analogues of UCS1025A and B by Cyclization of Maleimides: Synthesis and Biological Activity

Abstract

Application of a direct ring-closing approach which exploits an intramolecular aldol reaction with a ketene silyl acetal onto a remote imide function leading to the core skeleton of UCS1025A and B effectively provides access to small library of substituted analogues; of interest is their complete lack of antibacterial activity against MRSA (Gram+) and E. coli (Gram–) bacterial strains.

Key words

lactams - aldol reaction - ketene silyl ether - cyclization - antibiotics

Publication History

Received: 18 October 2021

Accepted after revision: 10 December 2021

Article published online:
27 January 2022

• References and Notes

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