CC BY 4.0 · Surg J (N Y) 2020; 06(04): e175-e179
DOI: 10.1055/s-0040-1718699
Case Report

Central Pancreatectomy with Roux-en-Y Pancreaticojejunal Anastomosis—Report of Two Cases

1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
,
1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
,
Konstantinos Manesis
1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
,
Sotirios Theodoroleas
1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
,
Angeliki Bistaraki
2   Surgery Department, 417 Army Share Fund Hospital, Athens, Greece
,
George Boubousis
1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
,
1   2nd Department of General Surgery, 417 Army Share Fund Hospital, Athens, Greece
› Author Affiliations
Funding No funding was provided for this research.

Abstract

Background Central pancreatectomy (CP), a partial resection of the pancreas, is indicated for the excision of neuroendocrine tumors (NETs) of the pancreas, when located at the neck or the proximal body. Specifically, CP is preferable in functional NET and in nonfunctional sized 1 to 2 cm or/with proliferation marker Ki67 < 20% (Grade I/II). Postoperative leakage from the remaining pancreas constitutes the most frequent complication of CP (up to 63%). The aim of our study was to share the experience of our center in CP for NET, with pancreaticojejunal anastomosis.

Methods In 1 year, we performed CP in two patients, following the aforementioned criteria. They presented with tumor of the body of the pancreas, which was found in random check with computed tomography, with negative hormonal blood tests and they underwent magnetic resonance imaging and endoscopic ultrasound/fine-needle biopsy/pathological examination.

Results The patients underwent CP with Roux-en-Y pancreaticojejunal anastomosis of the distal pancreatic stump and jejunal patch of the proximal pancreatic stump. Histological exam revealed NET sized 2.8 cm and 1.45 cm, Grade I and II, respectively. Postoperatively both patients developed small pancreatic leakage, which did not affect their physical condition and stopped after 20 and 30 days. No one needed pancreatic enzymes supplements or developed new-onset diabetes mellitus.

Conclusion CP provided adequate, functional remaining pancreatic tissue in both patients. Small leakages were treated conservatively and retreated without septic complications. As a result, CP might be considered as safe and effective technique for pancreatic neck/proximal body NET.



Publication History

Received: 30 November 2019

Accepted: 19 May 2020

Article published online:
14 December 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Fitzgerald TL, Hickner ZJ, Schmitz M, Kort EJ. Changing incidence of pancreatic neoplasms: a 16-year review of statewide tumor registry. Pancreas 2008; 37 (02) 134-138
  • 2 Ehehalt F, Saeger HD, Schmidt CM, Grützmann R. Neuroendocrine tumors of the pancreas. Oncologist 2009; 14 (05) 456-467
  • 3 Yamaguchi T, Fujimori T, Tomita S. et al. Clinical validation of the gastrointestinal NET grading system: Ki67 index criteria of the WHO 2010 classification is appropriate to predict metastasis or recurrence. Diagn Pathol 2013; 8: 65
  • 4 Beger HG, Poch B, Mayer B, Siech M. New onset of diabetes and pancreatic exocrine insufficiency after pancreaticoduodenectomy for benign and malignant tumors: a systematic review and meta-analysis of long-term results. Ann Surg 2018; 267 (02) 259-270
  • 5 De Bruijn KM, van Eijck CH. New-onset diabetes after distal pancreatectomy: a systematic review. Ann Surg 2015; 261 (05) 854-861
  • 6 Kwon JH, Kim SC, Shim IK. et al. Factors affecting the development of diabetes mellitus after pancreatic resection. Pancreas 2015; 44 (08) 1296-1303
  • 7 Hirono S, Tani M, Kawai M. et al. A central pancreatectomy for benign or low-grade malignant neoplasms. J Gastrointest Surg 2009; 13 (09) 1659-1665
  • 8 Guillemin P, Bessot M. [Chronic calcifying pancreatitis in renal tuberculosis: pancreatojejunostomy using an original technic]. Mem Acad Chir (Paris) 1957; 83 (27-28): 869-871
  • 9 Letton AH, Wilson JP. Traumatic severance of pancreas treated by Roux-Y anastomosis. Surg Gynecol Obstet 1959; 109: 473-478
  • 10 Iacono C, Bortolasi L, Serio G. Is there a place for central pancreatectomy in pancreatic surgery?. J Gastrointest Surg 1998; 2 (06) 509-516 , discussion 516–517
  • 11 Adham M, Giunippero A, Hervieu V, Courbière M, Partensky C. Central pancreatectomy: single-center experience of 50 cases. Arch Surg 2008; 143 (02) 175-180 , discussion 180–181
  • 12 DiNorcia J, Ahmed L, Lee MK. et al. Better preservation of endocrine function after central versus distal pancreatectomy for mid-gland lesions. Surgery 2010; 148 (06) 1247-1254 , discussion 1254–1256
  • 13 Machado MA, Surjan RC, Epstein MG, Makdissi FF. Laparoscopic central pancreatectomy: a review of 51 cases. Surg Laparosc Endosc Percutan Tech 2013; 23 (06) 486-490
  • 14 Wayne M, Neragi-Miandoab S, Kasmin F, Brown W, Pahuja A, Cooperman AM. Central pancreatectomy without anastomosis. World J Surg Oncol 2009; 7: 67
  • 15 Crippa S, Bassi C, Warshaw AL. et al. Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg 2007; 246 (01) 69-76
  • 16 Müller MW, Friess H, Kleeff J. et al. Middle segmental pancreatic resection: an option to treat benign pancreatic body lesions. Ann Surg 2006; 244 (06) 909-918 , discussion 918–920
  • 17 Falconi M, Eriksson B, Kaltsas G. et al. Vienna Consensus Conference participants. ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors. Neuroendocrinology 2016; 103 (02) 153-171
  • 18 Lavu H, Knuth JL, Baker MS. et al. Middle segment pancreatectomy can be safely incorporated into a pancreatic surgeon's clinical practice. HPB (Oxford) 2008; 10 (06) 491-497
  • 19 Bassi C, Marchegiani G, Dervenis C. et al. International Study Group on Pancreatic Surgery (ISGPS). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery 2017; 161 (03) 584-591
  • 20 Bassi C, Dervenis C, Butturini G. et al. International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005; 138 (01) 8-13
  • 21 Xiao W, Zhu J, Peng L, Hong L, Sun G, Li Y. The role of central pancreatectomy in pancreatic surgery: a systematic review and meta-analysis. HPB (Oxford) 2018; 20 (10) 896-904
  • 22 Newhook TE, LaPar DJ, Lindberg JM, Bauer TW, Adams RB, Zaydfudim VM. Morbidity and mortality of pancreaticoduodenectomy for benign and premalignant pancreatic neoplasms. J Gastrointest Surg 2015; 19 (06) 1072-1077
  • 23 Goudard Y, Gaujoux S, Dokmak S. et al. Reappraisal of central pancreatectomy a 12-year single-center experience. JAMA Surg 2014; 149 (04) 356-363
  • 24 Paiella S, De Pastena M, Faustini F. et al. Central pancreatectomy for benign or low-grade malignant pancreatic lesions - A single-center retrospective analysis of 116 cases. Eur J Surg Oncol 2019; 45 (05) 788-792
  • 25 Perivoliotis K, Sioka E, Tatsioni A, Stefanidis I, Zintzaras E, Zacharoulis D. Pancreatogastrostomy versus pancreatojejunostomy: An up-to-date meta-analysis of RCTs. Int J Surg Oncol 2017; 2017: 7526494