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J Neurol Surg B Skull Base 2021; 82(06): 608-614
DOI: 10.1055/s-0040-1715809
Original Article

Regional Recurrences and Hyams Grade in Esthesioneuroblastoma

Hedyeh Ziai
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Eugene Yu
2   Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
,
Ilan Weinreb
3   Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
,
Bayardo Perez-Ordonez
3   Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
,
Christopher M. K. L. Yao
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Wei Xu
4   Department of Biostatistics, the Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada
,
Dongyang Yang
4   Department of Biostatistics, the Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada
,
Ian J. Witterick
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Eric Monteiro
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Ralph W. Gilbert
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Jonathan C. Irish
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Patrick J. Gullane
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
David P. Goldstein
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
,
Jolie Ringash
5   Department of Radiation Oncology, the Princess Margaret Cancer Centre, Toronto, Ontario, Canada
,
Andrew Bayley
5   Department of Radiation Oncology, the Princess Margaret Cancer Centre, Toronto, Ontario, Canada
,
John R. de Almeida
1   Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada
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Abstract

Objective The aim of this study is to determine if Hyams grade may help predict which patients with esthesioneuroblastoma (ENB) tumors are likely to develop regional recurrences, and to determine the impact of tumor extent on regional failure in ENB patients without evidence of nodal disease at presentation.

Design The study was designed as a retrospective review for ENB patients.

Settings The study was prepared at tertiary care academic center for ENB patients.

Participants Patients with ENB were included in the study.

Main Outcome Measures  Oncologic outcomes (5-year regional and locoregional control (LRC) and overall survival) in patients with Hyams low grade versus high grade. Oncologic outcomes based on radiographic disease extent.

Results A total of 43 patients were included. Total 25 patients (58%) had Hyams low-grade tumor, and 18 (42%) had high-grade tumor. Of the 34 patients without regional disease at presentation, 8 (24%) were treated with elective nodal radiation. There were no statistically significant differences in 5-year regional control in the Hyams low-grade versus high-grade groups (78 vs. 89%; p = 0.4). The 5-year LRC rates in patients with low grade versus high grade were 73 versus 89% (p = 0.6). The 5-year overall survival rates in patients with low-grade versus high-grade tumors were 86 versus 63% (p = 0.1). Radiographic extension of disease into the olfactory groove, olfactory nerve, dura, and periorbita were statistically associated with decreased 5-year overall survival (5-year OS 49 vs. 91% [p = 0.04], 49 vs. 91% [p = 0.04], 44 vs. 92% [p = 0.02], and 44 vs. 80% [p = 0.04], respectively).

Conclusion ENBs are associated with a risk of regional failure. The current analysis suggests that Hyams low-grade and high-grade malignancies have comparable rates of early and delayed regional recurrences, although small sample size may limit our conclusions.

Keywords

head and neck - esthesioneuroblastoma - Hyams grade - regional failure - elective neck treatment - radiation - survival

Note

This work was presented at the 29th Annual North American Skull Base Society Meeting in Orlando, Florida, United States, February 15, 2019.




Publikationsverlauf

Eingereicht: 11. Dezember 2019

Angenommen: 02. Juni 2020

Artikel online veröffentlicht:
05. Oktober 2020

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