PDF herunterladen
CC BY-NC-ND 4.0 · Eur J Dent 2020; 14(04): 683-691
DOI: 10.1055/s-0040-1713073
Review Article

Mineral Trioxide Aggregate Applications in Endodontics: A Review

Gabriele Cervino 
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Luigi Laino
2   Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Cesare D’Amico
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Diana Russo
2   Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy
,
Ludovica Nucci
2   Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy
,
Giulia Amoroso
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Francesca Gorassini
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Michele Tepedino
3   Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Clinica Odontoiatrica e Chirurgia Maxillo-Facciale, Roma-Università Cattolica del Sacro Cuore, Rome, Italy
,
Antonella Terranova
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Dario Gambino
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Roberta Mastroieni
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
,
Melek Didem Tözüm
4   Pre-Doctoral Clinics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States
,
Luca Fiorillo
1   Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Policlinico G. Martino, Messina, Italy
› Institutsangaben Funding None.
› Weitere Informationen
Auch verfügbar auf
   Lizenzen und Reprints

Abstract

A current topic in dentistry concerns the biocompatibility of the materials, and in particular, conservative dentistry and endodontics ones. The mineral trioxide aggregate (MTA) is a dental material with biocompatibility properties to oral and dental tissues. MTA was developed for dental root repair in endodontic treatment and it is formulated from commercial Portland cement, combined with bismuth oxide powder for radiopacity. MTA is used for creating apical plugs during apexification, repairing root perforations during root canal therapy, treating internal root resorption, and pulp capping. The objective of this article is to investigate MTA features from a clinical point of view, even compared with other biomaterials. All the clinical data regarding this dental material will be evaluated in this review article. Data obtained from the analysis of the past 10 years’ literature highlighted 19 articles in which the MTA clinical aspects could be recorded. The results obtained in this article are an important step to demonstrate the safety and predictability of oral rehabilitations with these biomaterials and to promote a line to improve their properties in the future.

Keywords

dental materials - Portland cements - dentin - pulp exposure - pulp capping - root canal filling


Publikationsverlauf

Artikel online veröffentlicht:
29. Juli 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Tu MG, Sun KT, Wang TH. et al. Effects of mineral trioxide aggregate and bioceramics on macrophage differentiation and polarization in vitro. J Formos Med Assoc 2019; 118 (10) 1458-1465
    CrossrefPubMedGoogle Scholar
  • 2 Serin Kalay T. Effects of intracoronal bleaching agents on the surface properties of mineral trioxide aggregate. Odontology 2019; 107 (04) 465-472
    CrossrefPubMedGoogle Scholar
  • 3 Lopes MB, Soares VCG, Fagundes FHR. et al. Analysis of molecular changes induced by mineral trioxide aggregate on sPLA2. Braz Dent J 2019; 30 (05) 453-458
    CrossrefGoogle Scholar
  • 4 Liu Y, Liu XM, Bi J. et al. Cell migration and osteo/odontogenesis stimulation of iRoot FS as a potential apical barrier material in apexification. Int Endod J 2020; 53 (04) 467-477
    CrossrefPubMedGoogle Scholar
  • 5 Lin YT, Lin YJ. Success rates of mineral trioxide aggregate, ferric sulfate, and sodium hypochlorite pulpotomies: a prospective 24-month study. J Formos Med Assoc 2019
  • 6 Lapinska B, Klimek L, Sokolowski J, Lukomska-Szymanska M. Dentine surface morphology after chlorhexidine application-SEM study. Polymers (Basel) 2018; 10 (08) 905
    CrossrefPubMedGoogle Scholar
  • 7 Cervino G, Fiorillo L, Spagnuolo G. et al. Interface between MTA and dental bonding agents: scanning electron microscope evaluation. J Int Soc Prev Community Dent 2017; 7 (01) 64-68
    CrossrefPubMedGoogle Scholar
  • 8 Lo Giudice G, Cutroneo G, Centofanti A. et al. Dentin morphology of root canal surface: a quantitative evaluation based on a scanning electronic microscopy study. BioMed Res Int 2015; 2015: 164065
    CrossrefPubMedGoogle Scholar
  • 9 Zarra T, Lambrianidis T, Vasiliadis L, Gogos C. Effect of curing conditions on physical and chemical properties of MTA. Int Endod J 2018; 51 (11) 1279-1291
    CrossrefPubMedGoogle Scholar
  • 10 Colombo M, Poggio C, Dagna A. et al. Biological and physico-chemical properties of new root canal sealers. J Clin Exp Dent 2018; 10 (02) e120-e126
    PubMedGoogle Scholar
  • 11 Lo Giudice G, Cicciù M, Cervino G, Lizio A, Visco AM. Flowable resin and marginal gap on tooth third medial cavity involving enamel and radicular cementum: a SEM evaluation of two restoration techniques. Indian J Dent Res 2012; 23 (06) 763-769
    CrossrefPubMedGoogle Scholar
  • 12 Fiorillo L, Cervino G, Herford AS. et al. Interferon crevicular fluid profile and correlation with periodontal disease and wound healing: a systemic review of recent data. Int J Mol Sci 2018; 19 (07) E1908
    CrossrefPubMedGoogle Scholar
  • 13 De Stefano R. Psychological factors in dental patient care: odontophobia. Medicina (Kaunas) 2019; 55 (10) 678
    CrossrefPubMedGoogle Scholar
  • 14 Cicciù M, Fiorillo L, Cervino G. Chitosan use in dentistry: a systematic review of recent clinical studies. Mar Drugs 2019; 17 (07) 417
    CrossrefPubMedGoogle Scholar
  • 15 Savovic J, Turner RM, Mawdsley D. et al. Association between risk-of-bias assessments and results of randomized trials in Cochrane reviews: the ROBES meta-epidemiologic study. Am J Epidemiol 2018; 187 (05) 1113-1122
    CrossrefPubMedGoogle Scholar
  • 16 Mansournia MA, Higgins JP, Sterne JA, Hernán MA. Biases in randomized trials: a conversation between trialists and epidemiologists. Epidemiology 2017; 28 (01) 54-59
    CrossrefPubMedGoogle Scholar
  • 17 Higgins JP, Altman DG, Gøtzsche PC. et al. Cochrane Bias Methods Group, Cochrane Statistical Methods Group. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343: d5928
    Google Scholar
  • 18 Coburn KM, Vevea JL. Publication bias as a function of study characteristics. Psychol Methods 2015; 20 (03) 310-330
    CrossrefPubMedGoogle Scholar
  • 19 Bachelet VC, Pardo-Hernandez H. Quality of reporting and risk of bias of randomized clinical trials published in Spanish and Latin American journals. Medwave 2019; 19 (01) e7573
    CrossrefPubMedGoogle Scholar
  • 20 Çelik BN, Mutluay MS, Arıkan V, Sarı Ş. The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth. Clin Oral Investig 2019; 23 (02) 661-666
    CrossrefPubMedGoogle Scholar
  • 21 Erfanparast L, Iranparvar P, Vafaei A. Direct pulp capping in primary molars using a resin-modified Portland cement-based material (TheraCal) compared to MTA with 12-month follow-up: a randomised clinical trial. Eur Arch Paediatr Dent 2018; 19 (03) 197-203
    CrossrefPubMedGoogle Scholar
  • 22 Koc Vural U, Kiremitci A, Gokalp S. Randomized clinical trial to evaluate MTA indirect pulp capping in deep caries lesions after 24-months. Oper Dent 2017; 42 (05) 470-477
    CrossrefPubMedGoogle Scholar
  • 23 Kang CM, Sun Y, Song JS. et al. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth. J Dent 2017; 60: 8-13
    CrossrefPubMedGoogle Scholar
  • 24 Bakhtiar H, Nekoofar MH, Aminishakib P. et al. Human pulp responses to partial pulpotomy treatment with TheraCal as compared with Biodentine and ProRoot MTA: a clinical trial. J Endod 2017; 43 (11) 1786-1791
    CrossrefPubMedGoogle Scholar
  • 25 Asl Aminabadi N, Satrab S, Najafpour E, Samiei M, Jamali Z, Shirazi S. A randomized trial of direct pulp capping in primary molars using MTA compared to 3Mixtatin: a novel pulp capping biomaterial. Int J Paediatr Dent 2016; 26 (04) 281-290
    CrossrefGoogle Scholar
  • 26 Aminabadi NA, Huang B, Samiei M, Agheli S, Jamali Z, Shirazi S. A randomized trial using 3Mixtatin compared to MTA in primary molars with inflammatory root resorption: a novel endodontic biomaterial. J Clin Pediatr Dent 2016; 40 (02) 95-102
    CrossrefPubMedGoogle Scholar
  • 27 Nowicka A, Wilk G, Lipski M, Kołecki J, Buczkowska-Radlińska J. Tomographic evaluation of reparative dentin formation after direct pulp capping with Ca(OH)2, MTA, Biodentine, and dentin bonding system in human teeth. J Endod 2015; 41 (08) 1234-1240
    CrossrefPubMedGoogle Scholar
  • 28 Kang CM, Kim SH, Shin Y. et al. A randomized controlled trial of ProRoot MTA, Ortho MTA and RetroMTA for pulpotomy in primary molars. Oral Dis 2015; 21 (06) 785-791
    CrossrefPubMedGoogle Scholar
  • 29 Bonte E, Beslot A, Boukpessi T, Lasfargues JJ. MTA versus Ca(OH)2 in apexification of non-vital immature permanent teeth: a randomized clinical trial comparison. Clin Oral Investig 2015; 19 (06) 1381-1388
    CrossrefPubMedGoogle Scholar
  • 30 Petrou MA, Alhamoui FA, Welk A, Altarabulsi MB, Alkilzy M, H. Splieth C. A randomized clinical trial on the use of medical Portland cement, MTA and calcium hydroxide in indirect pulp treatment. Clin Oral Investig 2014; 18 (05) 1383-1389
    CrossrefPubMedGoogle Scholar
  • 31 Hilton TJ, Ferracane JL, Mancl L. Northwest Practice-based Research Collaborative in Evidence-based Dentistry (NWP). Comparison of CaOH with MTA for direct pulp capping: a PBRN randomized clinical trial. J Dent Res 2013; 92 (07) (Suppl) 16S-22S
    CrossrefPubMedGoogle Scholar
  • 32 Gandolfi MG, Parrilli AP, Fini M, Prati C, Dummer PM. 3D micro-CT analysis of the interface voids associated with Thermafil root fillings used with AH Plus or a flowable MTA sealer. Int Endod J 2013; 46 (03) 253-263
    CrossrefPubMedGoogle Scholar
  • 33 Bernabé PF, Gomes-Filho JE, Bernabé DG. et al. Sealing ability of MTA used as a root end filling material: effect of the sonic and ultrasonic condensation. Braz Dent J 2013; 24 (02) 107-110
    CrossrefGoogle Scholar
  • 34 Sönmez IS, Oba AA, Sönmez D, Almaz ME. In vitro evaluation of apical microleakage of a new MTA-based sealer. Eur Arch Paediatr Dent 2012; 13 (05) 252-255
    CrossrefPubMedGoogle Scholar
  • 35 Leye Benoist F, Gaye Ndiaye F, Kane AW, Benoist HM, Farge P. Evaluation of mineral trioxide aggregate (MTA) versus calcium hydroxide cement (Dycal(®)) in the formation of a dentine bridge: a randomised controlled trial. Int Dent J 2012; 62 (01) 33-39
    CrossrefPubMedGoogle Scholar
  • 36 Ghoddusi J, Shahrami F, Alizadeh M, Kianoush K, Forghani M. Clinical and radiographic evaluation of vital pulp therapy in open apex teeth with MTA and ZOE. N Y State Dent J 2012; 78 (03) 34-38
    PubMedGoogle Scholar
  • 37 Hansen SW, Marshall JG, Sedgley CM. Comparison of intracanal EndoSequence root repair material and ProRoot MTA to induce pH changes in simulated root resorption defects over 4 weeks in matched pairs of human teeth. J Endod 2011; 37 (04) 502-506
    CrossrefPubMedGoogle Scholar
  • 38 Yildirim T, Taşdemir T, Orucoglu H. The evaluation of the influence of using MTA in teeth with post indication on the apical sealing ability. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108 (03) 471-474
    CrossrefPubMedGoogle Scholar
  • 39 Jinga SI, Voicu G, Stoica-Guzun A, Stroescu M, Grumezescu AM, Bleotu C. Biocellulose nanowhiskers cement composites for endodontic use. Dig J Nanomater Biostructures 2014; 9 (02) 543-550
    Google Scholar
  • 40 Voicu G, Bǎdǎnoiu AI, Ghiţulicǎ CD, Andronescu E. Sol-gel synthesis of white mineral trioxide aggregate with potential use as biocement. Dig J Nanomater Biostructures 2012; 7 (04) 1639-1646
    Google Scholar
  • 41 Tao O, Wu DT, Pham HM, Pandey N, Tran SD. Nanomaterials in craniofacial tissue regeneration: a review. Appl Sci 2019; 9 (02) 317
    CrossrefGoogle Scholar
  • 42 Jun SK, Yoon JY, Mahapatra C. et al. Ceria-incorporated MTA for accelerating odontoblastic differentiation via ROS downregulation. Dent Mater 2019; 35 (09) 1291-1299
    CrossrefPubMedGoogle Scholar
  • 43 Opačić-Galić V, Petrović V, Jokanović V, Živković S. Histological evaluation of tissue reactions to newly synthetized calcium silicate-and hydroxyapatite-based bioactive materials - in vivo study. Srp Arh Celok Lek 2017; 145 (00) 63-63
    Google Scholar
  • 44 Huq NL, Myroforidis H, Cross KJ. et al. The interactions of CPP-ACP with saliva. Int J Mol Sci 2016; 17 (06) E915
    CrossrefPubMedGoogle Scholar
  • 45 Heller D, Helmerhorst EJ, Oppenheim FG. Saliva and serum protein exchange at the tooth enamel surface. J Dent Res 2017; 96 (04) 437-443
    CrossrefGoogle Scholar
  • 46 Gibbins HL, Yakubov GE, Proctor GB, Wilson S, Carpenter GH. What interactions drive the salivary mucosal pellicle formation?. Colloids Surf B Biointerfaces 2014; 120: 184-192
    CrossrefPubMedGoogle Scholar
  • 47 Culp DJ, Robinson B, Parkkila S. et al. Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva. Biochim Biophys Acta 2011; 1812 (12) 1567-1576
    CrossrefPubMedGoogle Scholar
  • 48 Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat Nanotechnol 2010; 5 (08) 565-569
    CrossrefPubMedGoogle Scholar
  • 49 Khurshid Z, Zafar M, Qasim S, Shahab S, Naseem M, AbuReqaiba A. Advances in nanotechnology for restorative dentistry. Materials (Basel) 2015; 8 (02) 717-731
    CrossrefPubMedGoogle Scholar
  • 50 Kanaparthy R, Kanaparthy A. The changing face of dentistry: nanotechnology. Int J Nanomedicine 2011; 6: 2799-2804
    CrossrefPubMedGoogle Scholar
  • 51 Subramani K, Ahmed W, Hartsfield JK. Nanobiomaterials in Clinical Dentistry. 2012
    Google Scholar
  • 52 Cicciù M, Cervino G, Terranova A. et al. Prosthetic and mechanical parameters of the facial bone under the load of different dental implant shapes: a parametric study. Prosthesis 2020; 1: 41-53
    CrossrefGoogle Scholar
  • 53 Cicciù M. Prosthesis: new technological opportunities and innovative biomedical devices. Prosthesis 2020; 1: 1-2
    CrossrefGoogle Scholar
  • 54 Crimi S, Fiorillo L, Bianchi A. et al. Herpes virus, oral clinical signs and QoL: systematic review of recent data. Viruses 2019; 11 (05) 463
    CrossrefPubMedGoogle Scholar
  • 55 Zhang N, Zhang K, Xie X. et al. Nanostructured polymeric materials with protein-repellent and anti-caries properties for dental applications. Nanomaterials (Basel) 2018; 8 (06) 393
    CrossrefPubMedGoogle Scholar
  • 56 Guazzo R, Gardin C, Bellin G. et al. Graphene-based nanomaterials for tissue engineering in the dental field. Nanomaterials (Basel) 2018; 8 (05) 349
    CrossrefPubMedGoogle Scholar
  • 57 Troiano G, Laino L, Cicciù M. et al. Comparison of two routes of administration of dexamethasone to reduce the postoperative sequelae after third molar surgery: a systematic review and meta-analysis. Open Dent J 2018; 12: 181-188
    CrossrefPubMedGoogle Scholar
  • 58 Laino L, Cicciù M, Fiorillo L. et al. Surgical risk on patients with coagulopathies: guidelines on hemophiliac patients for oro-maxillofacial surgery. Int J Environ Res Public Health 2019; 16 (08) 1386
    CrossrefPubMedGoogle Scholar
  • 59 Fiorillo L, De Stefano R, Cervino G. et al. Oral and psychological alterations in haemophiliac patients. Biomedicines 2019; 7 (02) 33
    CrossrefPubMedGoogle Scholar
  • 60 Cervino G, Fiorillo L, Monte IP. et al. Advances in antiplatelet therapy for dentofacial surgery patients: focus on past and present strategies. Materials (Basel) 2019; 12 (09) 1524
    CrossrefPubMedGoogle Scholar
  • 61 Herford AS, Lu M, Akin L, Cicciù M. Evaluation of a porcine matrix with and without platelet-derived growth factor for bone graft coverage in pigs. Int J Oral Maxillofac Implants 2012; 27 (06) 1351-1358
    Google Scholar
  • 62 Sambataro S, Cervino G, Bocchieri S, La Bruna R, Cicciù M. TMJ dysfunctions systemic implications and postural assessments: a review of recent literature. J Funct Morphol Kinesiol 2019; 4: 58
    CrossrefGoogle Scholar
  • 63 Sambataro S, Bocchieri S, Cervino G. et al. Correlations between malocclusion and postural anomalies in children with mixed dentition. J Funct Morphol Kinesiol 2019; 4: 45
    CrossrefGoogle Scholar
  • 64 Cicciù M, Risitano G, Lo Giudice G, Bramanti E. Periodontal health and caries prevalence evaluation in patients affected by Parkinson’s disease. Parkinsons Dis 2012; 2012: 541908
    PubMedGoogle Scholar
  • 65 Cicciù M, Bramanti E, Cecchetti F, Scappaticci L, Guglielmino E, Risitano G. FEM and Von Mises analyses of different dental implant shapes for masticatory loading distribution. Oral Implantol (Rome) 2014; 7 (01) 1-10
    PubMedGoogle Scholar
  • 66 Cicciù M, Beretta M, Risitano G, Maiorana C. Cemented-retained vs screw-retained implant restorations: an investigation on 1939 dental implants. Minerva Stomatol 2008; 57 (04) 167-179
    PubMedGoogle Scholar
  • 67 Algarni AA, Mussi MC, Moffa EB. et al. The impact of stannous, fluoride ions and its combination on enamel pellicle proteome and dental erosion prevention. PLoS One 2015; 10 (06) e0128196
    CrossrefPubMedGoogle Scholar
  • 68 Rodríguez-Lozano FJ, López-García S, García-Bernal D. et al. In vitro effect of putty calcium silicate materials on human periodontal ligament stem cells. Appl Sci 2020; 10 (01) 325
    CrossrefGoogle Scholar
  • 69 Tatullo M, Spagnuolo G, Codispoti B. et al. PLA-based mineral-doped scaffolds seeded with human periapical cyst-derived MSCs: a promising tool for regenerative healing in dentistry. Materials (Basel) 2019; 12 (04) E597
    CrossrefPubMedGoogle Scholar
  • 70 Spagnuolo G, Codispoti B, Marrelli M, Rengo C, Rengo S, Tatullo M. Commitment of oral-derived stem cells in dental and maxillofacial applications. Dent J (Basel) 2018; 6 (04) E72
    CrossrefPubMedGoogle Scholar
  • 71 de Oliveira NG, de Souza Araújo PR, da Silveira MT, Sobral APV, Carvalho MV. Comparison of the biocompatibility of calcium silicate-based materials to mineral trioxide aggregate: systematic review. Eur J Dent 2018; 12 (02) 317-326
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 72 Ferreira MM, Botelho MF, Abrantes M, Carvalho L, Carrilho E. Histologic evaluation of the effect of mineral trioxide aggregate-Fillapex as a root canal sealer in rat teeth submitted to late replantation. Eur J Dent 2017; 11 (01) 89-93
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 73 Scrascia R, Fiorillo L, Gaita V, Secondo L, Nicita F, Cervino G. Implant-supported prosthesis for edentulous patient rehabilitation. From temporary prosthesis to definitive with a new protocol: a single case report. Prosthesis 2020; 2 (01) 10-24
    CrossrefGoogle Scholar
  • 74 Ortensi L, Vitali T, Bonfiglioli R, Grande F. New tricks in the preparation design for prosthetic ceramic laminate veeners. Prosthesis 2019; 1 (01) 29-40
    CrossrefGoogle Scholar
  • 75 Lee DS, Lim MJ, Choi Y, Rosa V, Hong CU, Min KS. Tooth discoloration induced by a novel mineral trioxide aggregate-based root canal sealer. Eur J Dent 2016; 10 (03) 403-407
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 76 Bayram E, Bayram HM. Fracture resistance of immature teeth filled with mineral trioxide aggregate, bioaggregate, and Biodentine. Eur J Dent 2016; 10 (02) 220-224
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 77 Akcay H, Arslan H, Akcay M, Mese M, Sahin NN. Evaluation of the bond strength of root-end placed mineral trioxide aggregate and Biodentine in the absence/presence of blood contamination. Eur J Dent 2016; 10 (03) 370-375
    Artikel in Thieme ConnectPubMedGoogle Scholar