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CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2018; 54(02): 074-077
DOI: 10.1055/s-0040-1712789
Original Article

HCV Seroreactivity and Detection of HCV RNA in Hepatitis Cases

Mahantesh B Nagamoti
Department of Microbiology, J.N. Medical College, KLE University Belagavi
,
Chidanand S Patil
USM-KLE Medical School Belagavi
,
Jyoti M Nagamoti
Department of Microbiology, J.N. Medical College, KLE University Belagavi
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ABSTRACT

Background: Hepatitis C virus (HCV) known to be associated with wide variety of liver pathology. It is less studied in India as compared to western region.

Methods: Suspected patients sera screened for HCV by ELISA and confirmed with reverse transcription polymerase chain reaction (RT-PCR) along with routine investigations and liver profile. All HCV positive patients were undergone liver biopsy.

Results: All 24 HCV ELISA reactive and two ELISA indeterminate sera are confirmed by RT- PCR. The liver biopsy of these patients showed normal picture (19.2%), Acute hepatitis (11.5%), Chronic hepatitis (23.7%), Cirrhosis (34.72%), Hepato-cellular carcinoma (HCC) (15.38%). ALT levels were not significant.

Conclusion: All the suspected HCV cases need to be confirmed for HCV by RT-PCR.

Keywords:

Hepatitis C virus (HCV)> - HCV RT-PCR - ALT levels - liver pathology


Publication History

Article published online:
08 May 2020

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