Evaluation of Analgesic Effect of Ropivacaine versus Ropivacaine with Clonidine in Caudal Epidural Block in Lumbosacral Spine Surgery

Background: To compare effect of 0.2% ropivacaine alone versus 1 µg/kg of Clonidine with 0.2% ropivacaine in caudal epidural block in lumbosacral spine surgery with respect to VAS score, duration of analgesia, hemodynamics, and associated side effects.

Materials and Methods: A double blinded controlled interventional study was performed in which a total of 72 patients of lumbosacral spine surgery were studied and randomized into two groups. Each group received 20 mL of caudal epidural injection either of 0.2% ropivacaine alone (group A) or 1 mg/kg of injection clonidine with 0.2% ropivacaine (group B) according to group allocation after patient was placed prone for surgery after general anesthesia. VAS score, duration of analgesia, sedation score, and side effects were recorded at regular interval postoperatively up to 24 hours and hemodynamics were recorded in both intraoperative and postoperative period.

Results: Mean VAS scores were significantly lower in group B as compared with group A for the first 12 hours postoperatively. Significant difference was observed in duration of analgesia between both the groups. Group B showed prolonged duration of analgesia. There were no significant differences observed with respect to hemodynamics, sedation score, and side effect profile of patients in both groups.

Conclusions: The results suggested that injection clonidine is a good and effective adjuvant for analgesia to 0.2% injection ropivacaine for caudal epidural block in lumbosacral spine surgery.

Publikationsverlauf

Artikel online veröffentlicht:
25. März 2020