Download PDF
CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2016; 06(01): 074-079
DOI: 10.1055/s-0040-1708622
Review Article

Local Drug Delivery in periodontal diseases. ……A Review

Amitha Ramesh
1   Professor, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore
,
Agumbe Priyanka Prakash
2   Post Graduate, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore
,
Biju Thomas
3   HOD, Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore
› Author Affiliations
› Further Information
  PDF Download Permissions and Reprints

Abstract

Periodontitis is an immuno-inflammatory disease of the tissues surrounding the teeth. Various treatment modalities like mechanical debridement and use of antimicrobials have been followed in the treatment of such conditions. Introduction of local drug delivery system in the periodontal pocket is a promising therapeutic modality for achieving better clinical outcomes when used as an adjunct to conventional non surgical periodontal therapy. Intensive research efforts are now focussed on the development of new strategies for more effective treatment.

Keywords:

Periodontitis - local drug delivery - scaling and root planning - antimicrobial agent


Publication History

Article published online:
22 April 2020

© .

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Newman, Takei, Klokkevold, Carranza. Carranza's clinical th periodontology 2010;pp 798-803, Chemotherapeutic agents,10 edition.2010;Elsevier, Reed Elsevier India Private Limited.
  • 2 Dodwad V, Vaish S, Mahajan A, Chhokra M. Local drug delivery in periodontics: a strategic intervention. International Journal of Pharmacy and Pharmaceutical Sciences.2004;4(4):30-4.
  • 3 Pragati S, Ashok S., KuldeepS. Recent advances in periodontal drug delivery systems. International Journal of Drug Delivery Jan 2009;1 : 1- 9.
  • 4 Gordon JM, Walker CB.Current status of systemicantibiotic usage in destructive periodontal disease. J Periodontol 1993; 64: 760-771.
  • 5 Divya P.V, K. Nandakumar: "Local Drug Delivery---Periocol" In Periodontics;trendsbiometer. Artif.Organs.2010; 19(2): 74-80.
  • 6 Chadha VS, Arora K, Manjunath B C, SarikaKalra: local drug delivery in periodontics: current concepts and trends; International Journal of Advanced Research On Oral Sciences 2012; 1(1): 1 -9.
  • 7 Goodson JM, Hafajee A, Socransky SS. Periodontal therapy by local delivery of tetracycline. J Clinical Periodontol 1979; 6: 83-92.
  • 8 Rams TE, Slots J. Local delivery of antimicrobial agents in the periodontal pocket. Periodontology 2000. 1996 Feb ; 10: 139-159.
  • 9 Greenstein G, Tonetti M. The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology. J Periodontl 2000 Jan; 71(1):125-140.
  • 10 Ashtaputre V,Limaye M. Local drug delivery in periodontics:A tactical entreaty. Journal of Research in Pharmaceutical Science2014; 2 (1): 06-11.
  • 11 Maheshwari M, Miglani G, Mali A, Paradkar A, Yamamura S, Kadam S. Development of Tetracycline-Serratiopeptidase- Containing Periodontal Gel: Formulation and Preliminary Clinical Study; AAPS Pharm Sci Tech 2006; 7 (3):162-171.
  • 12 Newman MG, Kornman KS, Doherty FM. A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling androot planing in maintenance patients:clinical results. J PeriodontolJuly 1994; 65: 685-691.
  • 13 Walker C, Godowski K, Borden L, Lennon J, Nango S, Stone C, & Garrett S.The effects of sustained release doxycycline on the anaerobic flora and antibiotic –resistant patterns in subgingival plaque and saliva. JPeriodontol 2000;71:768-774.
  • 14 Renvert S, Lessem J, Dahlen G, Renvert H,Lindahl C. Mechanical and Repeated AntimicrobialTherapy Using a Local Drug DeliverySystemin theTreatment of Peri-Implantitis:A Randomized Clinical Trial. J Periodontol 2008;79: 836-844.
  • 15 Shifrovitch Y, Binderman I, Bahar H, Berdicevsky I, Zilberman M. Metronidazole-Loaded Bioabsorbable Films as Local Antibacterial Treatmentof Infected Periodontal Pockets. J Periodontol 2009;80:330- 7.
  • 16 Varma A, Sanghi S, Grover D, Aggarwal S, Gupta R, Pandit N. Effect of insertion of xanthan-based chlorhexidine gel in the maintenance phase following the treatment of chronic periodontitis. J Indian Soc Periodontol. 2012 Jul-Sep; 16(3): 381–5.
  • 17 Chava VK, Vedula BD. Thermo-reversible green tea catechin gel for local application in chronic periodontitis: a 4-week clinical trial. J Periodontol 2013;84:1290-6.
  • 18 Pradeep AR, Rao NS, Naik SB, Kumari M. Efficacy of varying concentrations of subgingivally delivered metformin in the treatment of chronic periodontitis: a randomized controlled clinical trials. J of Periodontal. Feb 2013;84:133-135.
  • 19 Pradeep AR, Kumari M, Rao NS, Martande SS, Naik SB. Clinical Efficacy of subgingivallydelivered 1.2% Atorvastatin in chronicperiodontitis: A Randomized Controlled Clinical Trial. Journal of Periodontology. July 2013; 84(7): 871-9.
  • 20 Williams RC, Paquette DW, Offenbacher S. Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. Journal of Periodontology. November 2001;72(1):11-4.
  • 21 Ramesh A, Thomas B, Sathish M. Comparative evaluation of subgingival application of chlorhexidine varnish and chlorhexidine gel as an adjunct to full mouth scaling and root planing in the treatment of moderate to deep periodontal pockets –Aclinical study.JIDA2010;8( 3):35-40.
  • 22 Agarwal E, Pradeep AR, Bajaj P, Naik SB. Efficacy of local drug delivery of 0.5% Clarithromycin gel as an adjunct to non-surgical periodontal therapy in the treatment of current smokers with chronic periodontitis: A randomized controlled clinical trial. J.Periodontal September 2012;83:1155-1163.
  • 23 Pradeep AR, Sharma A, Rao NS, Bajaj P, Naik SB, Kumari M. Local drug delivery of alendronate gel for the treatment of patients withchronic periodontitis with diabetes mellitus: a double-masked controlledclinicaltrial;j. Periodontal .oct 2012; 83(10):1322-8.
  • 24 Pradeep AR, Kumari M, Rao NS, Naik SB .1% Alendronate gel as local drugdelivery in the treatment of class iifurcation defects: a randomizedcontrolled clinical trial.j.periodontal march 2012; vol 84( 3):307-315.
  • 25 Baiju CS, Manchanda S .Chair side therapeutic aids in periodontics. Heal talk. Nov-Dec 2010;3(2):41-2.