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Synthesis 2021; 53(07): 1356-1364
DOI: 10.1055/s-0040-1707329
DOI: 10.1055/s-0040-1707329
paper
Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines
This project was supported by the National Key Research and Development Program of China (No. 2017YFE0102200), the National Natural Science Foundation of China (No. 81673291), and the Diabetes National Research Group, USA (to Y.Y.). The authors also acknowledge the Natural Science Foundation of Zhejiang Province (No. LY18H300001) and the Multiple Sclerosis National Research Institute, USA (to W.C.).
Abstract
A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand.
Key words
4-arylquinazolines - palladium(II) catalysis - one-pot assembly - tandem cyclization reaction - ligandsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707329.
- Supporting Information
Publication History
Received: 24 August 2020
Accepted after revision: 16 September 2020
Article published online:
19 October 2020
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