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DOI: 10.1055/s-0040-1707268
Recent Advances in Palladium-Catalyzed Bridging C–H Activation by Using Alkenes, Alkynes or Diazo Compounds as Bridging Reagents
We are grateful for financial support from the National Natural Science Foundation of China (NSFC) (Grant Nos. 21402197, 21871259, and 21901244), the Hundred Talents Program, and the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000).
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Dedicated to the 60th anniversary of the Fujian Institute of Research on the Structure of Matter
Abstract
Transition-metal-catalyzed direct inert C–H bond functionalization has attracted much attention over the past decades. However, because of the high strain energy of the suspected palladacycle generated via C–H bond palladation, direct functionalization of a C–H bond less than a three-bond distance from a catalyst center is highly challenging. In this short review, we summarize the advances on palladium-catalyzed bridging C–H activation, in which an inert proximal C–H bond palladation is promoted by the elementary step of migratory insertion of an alkene, an alkyne or a metal carbene intermediate.
1 Introduction
2 Palladium-Catalyzed Alkene Bridging C–H Activation
2.1 Intramolecular Reactions
2.2 Intermolecular Reactions
3 Palladium-Catalyzed Alkyne Bridging C–H Activation
3.1 Intermolecular Reactions
3.2 Intramolecular Reactions
4 Palladium-Catalyzed Carbene Bridging C–H Activation
5 Conclusion and Outlook
Key words
palladium catalysis - bridging C–H activation - alkenes - alkynes - diazo compounds - migratory insertionPublikationsverlauf
Eingereicht: 05. Juni 2020
Angenommen nach Revision: 04. August 2020
Artikel online veröffentlicht:
22. September 2020
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