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DOI: 10.1055/s-0040-1707139
Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery
This work was supported by the United States Department of Energy (DE-SC0004888).Publication History
Received: 11 April 2020
Accepted after revision: 14 May 2020
Publication Date:
18 June 2020 (online)
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Abstract
Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Several approaches to addressing these problems have been pursued, but there is still a need for a general method for stabilizing the amorphous form. We describe a novel approach using a water-unstable metal-organic framework as a drug delivery vehicle that demonstrates improved amorphous form stability accompanied by remarkably enhanced solubility and a fast dissolution rate. This research project spanned eleven years from conception to realization and dissemination. With origins in understanding the stability or porous solids for energy storage materials, the work also highlights potential of basic science understanding to illuminate new areas of application.
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References and Notes
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Current addresses:
We recently began exploring the ‘conventional’ approach of using organic polymers for this task with the added twist that we used postsynthetic functionalization of polymers in order to explore functional group effects in isolation: