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Synlett 2020; 31(12): 1226-1230
DOI: 10.1055/s-0040-1707131
DOI: 10.1055/s-0040-1707131
letter
Copper-Catalyzed Methylthiolation of Aryl Iodides and Bromides with Dimethyl Disulfide in Water
We are grateful for financial support from the Natural Science Foundation of Zhejiang Province (No. LY18B020004) and the National Natural Science Foundation of China (No. 21572094).Further Information
Publication History
Received: 06 February 2020
Accepted after revision: 23 April 2020
Publication Date:
02 July 2020 (online)
Abstract
An efficient route to aryl methyl sulfides through the copper-catalyzed coupling reaction of aryl iodides or bromides with dimethyl disulfide in water is described. Electron-donating and electron-withdrawing functional groups in the substrates were tolerated, and the corresponding products were obtained in moderate to good yields.
Key words
methylthiolation - aryl halides - dimethyl disulfide - aryl methyl sulfides - copper catalysisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707131.
- Supporting Information
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