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Synthesis 2021; 53(06): 1061-1076
DOI: 10.1055/s-0040-1706146
DOI: 10.1055/s-0040-1706146
short review
Alkylzirconocenes in Organic Synthesis: An Overview
This work was supported by the Ministry of Science and Technology of the People’s Republic of China (Grant No. 2014CB849603), the National Natural Science Foundation of China (NSFC) (Grant No. 21772092) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), China.
Abstract
Organozirconium chemistry has found extensive applications in organic synthesis since its discovery in the last century. Alkylzirconocenes, which are easily generated by the hydrozirconation of alkenes with the Schwartz reagent, are widely utilized for carbon–carbon and carbon–heteroatom bond formation. This short review summarizes the progress to date on the applications alkylzirconocenes in organic synthesis.
1 Introduction
2 General Methods for Generating Alkylzirconocenes
3 Transformations of Alkylzirconocenes by Heteroatoms
4 Insertion of Unsaturated Groups into Alkylzirconocenes
5 Transmetalations
6 Cross-Coupling Reactions of Alkylzirconocenes
7 Photochemistry of Alkylzirconocenes
8 Bimetallic Reagents of Zirconium
9 Asymmetric Transformations
10 Applications of Alkylzirconocenes Generated from the Negishi Reagent
11 Conclusions and Outlook
Publication History
Received: 04 November 2020
Accepted after revision: 11 January 2021
Article published online:
11 February 2021
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