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Synthesis 2021; 53(08): 1503-1512
DOI: 10.1055/s-0040-1706089
DOI: 10.1055/s-0040-1706089
paper
Facile Access to 3,4-Disubstituted 2H-Chromenes via Domino [4+2] Annulation
We thank the National Research Foundation of Korea (NRF-2018R1A6A1A03023718 and NRF-2020R1A2C2005961) for generous financial support.
Abstract
A highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner–Wadsworth–Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.
Key words
chemical space - 2H-chromenes - domino reaction - intramolecular reaction - Horner–Wadsworth–Emmons olefination - one-pot three-component reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706089.
- Supporting Information
Publication History
Received: 01 October 2020
Accepted after revision: 02 November 2020
Article published online:
19 November 2020
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