Simple Synthesis of Substituted 3-Hydroxyfuran-2(5H)-ones

Abstract

A convenient and facile approach to functionalized 4-substituted 3,5-dihydroxy-5-(trichloromethyl)furan-2(5H)-ones was developed. This method is based on regioselective synthesis of novel furan-2,3-diones containing the trichloromethyl group and subsequent hydrolysis. The structures of compounds were unambiguously confirmed by single-crystal X-ray diffraction.

Key words

β-diketones - trichloromethyl derivatives - cyclization - furan-2,3-diones

Publication History

Received: 17 October 2020

Accepted after revision: 19 November 2020

Article published online:
11 January 2021

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