CC BY-NC-ND 4.0 · SynOpen 2020; 04(04): 99-106
DOI: 10.1055/s-0040-1705982
paper

Iodine-Mediated Facile One-Pot Access to N-Aryl-2-benzoxazolamines

Haruna Nariki
,
Takuya Miyamura
,
Daiki Matsui
,
Motohiro Sonoda
,
This work was supported by Japan Society for the Promotion of Science (JSPS KAKENHI JP 17K07776 to S.T. and JP 17H06092).


Abstract

Facile, iodine-mediated access to N-aryl-2-benzoxazolamines has been achieved in a one-pot manner under mild reaction conditions. Reaction of 2-aminophenols and aryl isothiocyanates afforded N-aryl-2-benzoxazolamines in the presence of molecular iodine and pyridine in tetrahydrofuran at room temperature in moderate to excellent yields.

Supporting Information



Publication History

Received: 12 October 2020

Accepted after revision: 11 November 2020

Article published online:
24 November 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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