Synthesis 2021; 53(05): 889-903
DOI: 10.1055/s-0040-1705969
short review

Recent Application of Chiral Aryliodine Based on the 2-Iodo­resorcinol Core in Asymmetric Catalysis

Yang Wang
,
Bing Yang
,
Xin-Xing Wu
,
Zheng-Guang Wu
We are grateful for generous financial support from the Program of High-level Talents (03083031) of Nantong University and the National Natural Science Foundation of China (21772086).


In memory of Prof. Kilian Muñiz (1970–2020).

Abstract

Chiral iodoarenes have been steadily increasing in importance in recent years, especially in enantioselective synthesis and catalysis. Since the development of the concept of chiral iodine(I/III) catalysis, the use of various chiral aryliodine frameworks has been explored in this area. This short review gives an overview of the use of chiral hypervalent iodine(I/III) reagents based on the 2-iodoresorcinol core with two attached two lactic side chains bearing ester or amide groups for the catalytic enantioselective dearomatization of phenol compounds, asymmetric oxidation of alkenes, and enantioselective α-functionalization of carbonyl compounds highlighting the excellent reactivities in terms of yield and enantioselectivity.

1 Introduction

2 Enantioselective Dearomatization of Phenol Derivatives

3 Asymmetric Oxidation of Alkenes

4 Enantioselective α-Functionalization of Carbonyl Compounds

5 Conclusion and Outlook



Publikationsverlauf

Eingereicht: 28. September 2020

Angenommen nach Revision: 08. Oktober 2020

Artikel online veröffentlicht:
12. November 2020

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