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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2015; 05(04): 022-025
DOI: 10.1055/s-0040-1703929
Original Article

Extent of awareness regarding periodontal disease in diabetic patients among medical interns

Manav Chaturvedi
1   Post Graduate, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Sreelatha S. V.
2   Reader, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
,
Pushparaja Shetty
3   Professor & HOD, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences, Nitte University, Mangalore, Karnataka, India
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Abstract

Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity. Betel nut chewing, cigarette smoking and alcohol drinking are thought to be the major environment risk factors responsible for the development of oral squamous cell carcinoma (OSCC).

Reports of OSCC in patients who never used tobacco and alcohol are infrequent.

The aim of this article is to review the current data concerning the possible etiological factors causing OSCC other than tobacco like viral infections, diet, nutrition, chronic irritation, genetic mutations and other. Although it is well known that the incidence of OSCC increases with age, recent trends for a rising incidence particularly relates to cancer in young individuals. Investigations can be routine ranging from simple oral examination, blood test, bone marrow analysis, diet chart analysis as well as molecular analysis through techniques like PCR, ISH (in situ hybridization), DNA sequencing, southern blot and antibody test.

This review critically examines numerous publications devoted to oral cancer in young individuals who never used tobacco and alcohol. Most studies suggest that 4-6% of oral cancer occur in such individuals

Awareness of this possibility is important since it can lead to potentially fatal consequences.Thus providing clinicians a broader vision for diagnosis which will lead to effective treatment and prevention in the future.

Keywords

Viral infections - chronic mechanical trauma - diet


Publication History

Article published online:
22 April 2020

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  • References

  • 1 American Cancer Society. Cancer Facts and Figures 2012. Atlanta:American Cancer Society; 2012.
  • 2 Ferreira F.V, Nedel. F, et al. Etiologic factors associated with oral squamous cell carcinoma in non-smokers and non-alcoholic drinkers. Braz Dent J 2012; 23(5): 586-590
  • 3 Andrews. E, Seaman.W.T, et al. Oropharyngeal carcinoma in nonsmokers and non-drinkers: A role for HPV.Oral Oncology 2009; 45: 486– 491
  • 4 Randhawa T, Shameena P.M, Sudha S, Nair R.G, et al. Squamous cell carcinoma of tongue in a 19-year-old female.Indian journal of cancer 2008; 45(3);128-130
  • 5 Mehrotra R, Yadav S, et al. Squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations oral squamous cell carcinoma. Indian journal of cancer 2006; 43(2):60-66
  • 6 Gupta.K and Metgud. R et al. Evidences suggesting involvement of viruses in oral squamous cell carcinoma. Article ID 642496. Pathology Research International 2013:1-17
  • 7 Mirghani.H, Amen.F, et al. Human papilloma virus testing in oropharyngeal squamous cell carcinoma: What the clinician should know.Oral oncology 2014; 50 :1–9
  • 8 Villaret DB, Wang T, Dillon D, Xu J, Sivam D, Cheever MA, et al. Identification of genes over expressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope 2000;110:374-81.