RSS-Feed abonnieren
DOI: 10.1055/s-0040-1701221
Sinonasal Osteosarcoma: Report of 14 New Cases and Systematic Review of the Literature
Funding Internal departmental funding was utilized without commercial sponsorship or support.![](https://www.thieme-connect.de/media/jnlsb/2021S03/lookinside/thumbnails/10-1055-s-0040-1701221_190184-1.jpg)
Abstract
Objective The objective of this study is to describe the clinical presentation, tumor characteristics, natural history, and treatment patterns of sinonasal osteosarcoma.
Methods Fourteen patients who had been treated for osteosarcoma of the nasal cavity and paranasal sinuses at a tertiary care center were reviewed. In addition, a systematic review of the literature for osteosarcoma of the sinonasal cavity was performed.
Results In a systematic review, including 14 patients from the authors' institution, 53 total studies including 88 patients were assessed. Median follow-up was 18 months (interquartile range: 8–39 months). The most common presenting symptoms were facial mass or swelling (34%), and nasal obstruction (30%). The most common paranasal sinus involved by tumor was the maxillary sinus (64%), followed by the ethmoid sinuses (52%). The orbit (33%), dura (13%) and infratemporal fossa (10%) were the most common sites of local invasion. The majority of patients underwent surgery followed by adjuvant therapy (52.4%). Increasing age was associated with decreased overall survival rate (unit risk ratio [95% confidence interval (CI)] = 1.02 [1.003–1.043]; p = 0.0216) and T4 disease was associated with decreased disease-specific survival rate (hazard ratio [HR] = 2.87; p = 0.0495). The 2- and 5-year overall survival rates were 68 and 40%, respectively, while 2- and 5-year disease-specific survival rates were 71% and 44%, respectively.
Conclusion Sinonasal osteosarcomas are uncommon tumors and can pose a significant therapeutic challenge. Increasing age and T4 disease are associated with worse prognosis. This disease usually warrants consultation by a multidisciplinary team and consideration of multimodality therapy.
Keywords
osteogenic sarcoma - osteosarcoma - nasal cavity - paranasal sinuses - sinonasal - EEA - expanded endonasal approachPublikationsverlauf
Eingereicht: 20. Juni 2019
Angenommen: 12. November 2019
Artikel online veröffentlicht:
24. Januar 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Kassir RR, Rassekh CH, Kinsella JB, Segas J, Carrau RL, Hokanson JA. Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies. Laryngoscope 1997; 107 (01) 56-61
- 2 Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. In: Jaffe E, Bruland OS, Bielack S. eds. Pediatric and Adolescent Osteosarcoma. New York, NY: Springer-Verlag; 2009: 3-13
- 3 Noone A, Howlader N, Krapcho M. et al. SEER Cancer Statistics Review, 1975–2015. National Cancer Institute; Bethesda, MD: 2018
- 4 Goorin AM, Abelson HT, Frei III E. Osteosarcoma: fifteen years later. N Engl J Med 1985; 313 (26) 1637-1643
- 5 Wanebo HJ, Koness RJ, MacFarlane JK. et al; Society of Head and Neck Surgeons Committee on Research. Head and neck sarcoma: report of the Head and Neck Sarcoma Registry. Head Neck 1992; 14 (01) 1-7
- 6 Vege DS, Borges AM, Aggrawal K, Balasubramaniam G, Parikh DM, Bhaser B. Osteosarcoma of the craniofacial bones. A clinico-pathological study. J Craniomaxillofac Surg 1991; 19 (02) 90-93
- 7 Oda D, Bavisotto LM, Schmidt RA. et al. Head and neck osteosarcoma at the University of Washington. Head Neck 1997; 19 (06) 513-523
- 8 Ackland D, Robinson D, Lee PVS, Dimitroulis G. Design and clinical outcome of a novel 3D-printed prosthetic joint replacement for the human temporomandibular joint. Clin Biomech (Bristol, Avon) 2018; 56: 52-60
- 9 Hauff SJ, Leuin S, Nation J, Korn BS, Levy M, DeConde A. Osteosarcoma of the skull base in the pediatric population: A case report and literature review. Journal of Neurological Surgery, Part B: Skull Base Conference: 26th Annual Meeting North American Skull Base Society Scottsdale, AZ, United States Conference Publication. 2016: 77
- 10 Yamada SM, Ishii Y, Yamada S, Kuribayashi S, Kumita S, Matsuno A. Advanced therapeutic strategy for radiation-induced osteosarcoma in the skull base: a case report and review. Radiat Oncol 2012; 7: 136
- 11 Echchikhi Y, Loughlimi H, Touil A, Kebdani T, Benjaafar N. Radiation-induced osteosarcoma of the skull base after radiation therapy in a patient with nasopharyngeal carcinoma: a case report and review of the literature. J Med Case Reports 2016; 10 (01) 334
- 12 Guo B, Moga C, Harstall C, Schopflocher D. A principal component analysis is conducted for a case series quality appraisal checklist. J Clin Epidemiol 2016; 69: 199-207.e2
- 13 Ahrari A, Labib M, Gravel D, Macdonald KI. Primary osteosarcoma of the skull base treated with endoscopic endonasal approach: A case report and literature review. J Neurol Surg Rep 2015; 76 (02) e270-e274
- 14 Yip C-C, Kersten RC, McCulley TJ, Ballard ET, Kulwin DR. Osteogenic sarcoma after orbital radiation rhabdomyosarcoma. Ophthalmology 2003; 110 (10) 1996-1999
- 15 Alzahrani M, Robier A, Pointreau Y, Bakhos D. A rare case of radiation-induced osteosarcoma of the ethmoid sinus. Case Rep Otolaryngol 2011; 2011: 786202
- 16 Amaral MB, Buchholz I, Freire-Maia B. et al. Advanced osteosarcoma of the maxilla: a case report. Med Oral Patol Oral Cir Bucal 2008; 13 (08) E492-E495
- 17 Avitia S, Osborne RF. Radiation-induced osteosarcoma of the maxillary sinus. Ear Nose Throat J 2007; 86 (06) 329-330
- 18 Barosa J, Ribeiro J, Afonso L, Fernandes J, Monteiro E. Head and neck sarcoma: analysis of 29 cases. Eur Ann Otorhinolaryngol Head Neck Dis 2014; 131 (02) 83-86
- 19 Bone RC, Biller HF, Harris BL. Osteogenic sarcoma of the frontal sinus. Ann Otol Rhinol Laryngol 1973; 82 (02) 162-165
- 20 Bradley C, McClymont LG, Reid R. Osteogenic sarcoma of the ethmoid sinus. J Laryngol Otol 1988; 102 (12) 1176-1178
- 21 Bundgaard T, Frost-Jensen V, Buhl L. Sarcomatous change in a previously benign osteofibroma in the maxillary sinus. Arch Otorhinolaryngol 1988; 245 (01) 22-24
- 22 Chaudhari C S, Kumavat P V, Khare M S, Ughade P A, Kshirsagar G R. Primary osteogenic sarcoma of fronto ethmoidal sinuses in a child: with unusual site and age group. Bombay Hosp J 2015; 57 (02) 217-220
- 23 Chennupati SK, Norris R, Dunham B, Kazahaya K. Osteosarcoma of the skull base: case report and review of literature. Int J Pediatr Otorhinolaryngol 2008; 72 (01) 115-119
- 24 Donaldson ME, Geist JR, Daley TD. Osteosarcoma of the jaws in children. Int J Paediatr Dent 2004; 14 (01) 54-60
- 25 Epley KD, Lasky JB, Karesh JW. Osteosarcoma of the orbit associated with Paget disease. Ophthal Plast Reconstr Surg 1998; 14 (01) 62-66
- 26 Erdur ZB, Gözen ED, Inan HC. et al. Osteosarcoma of the ethmoid sinus. J Craniofac Surg 2018; 29 (05) e487-e488
- 27 Gadwal SR, Gannon FH, Fanburg-Smith JC, Becoskie EM, Thompson LD. Primary osteosarcoma of the head and neck in pediatric patients: a clinicopathologic study of 22 cases with a review of the literature. Cancer 2001; 91 (03) 598-605
- 28 Galera-Ruiz H, Sanchez-Calzado JA, Rios-Martin JJ, DeMingo-Fernandez EJ, Muñoz Borge F. Sinonasal radiation-associated osteosarcoma after combined therapy for rhabdomyosarcoma of the nose. Auris Nasus Larynx 2001; 28 (03) 261-264
- 29 Ginapolous H, Khan FR, Nickson JJ. A case of osteogenic sarcoma of maxillary antrum cure by radiation therapy. J Radiol Electrol Med Nucl 1975; 56 (05) 429-431
- 30 Gonzalez ME, Raghavan P, Cho B, Muttikkal TJ, Rehm PK. Primary osteogenic osteosarcoma of the ethmoid sinus in an adolescent: case report. J Radiol Case Rep 2016; 10 (02) 1-9
- 31 Gupta D, Vishwakarma SK. Osteogenic sarcoma of the frontal sinus. Ann Otol Rhinol Laryngol 1990; 99 (6, Pt 1): 489-490
- 32 Ha PK, Eisele DW, Frassica FJ, Zahurak ML, McCarthy EF. Osteosarcoma of the head and neck: a review of the Johns Hopkins experience. Laryngoscope 1999; 109 (06) 964-969
- 33 Harris HH, Muller DJ, Greenberg SD. Primary osteogenic sarcoma of the maxillary sinus. Report of two cases. Laryngoscope 1963; 73: 429-445
- 34 Ito T, Ozaki Y, Sato K, Oikawa M, Nakamura H. Radiation-induced osteosarcomas after treatment for frontal gliomas: a report of 2 cases. Neuro-oncol 2010; 27 (02) 103-109
- 35 Kachhara R, Nair S, Sandhyamani S, Bhattacharya RN. Primary osteogenic sarcoma involving sella-sphenoid sinus--case report. Neurol Med Chir (Tokyo) 1999; 39 (07) 534-538
- 36 Khosla A, Goulatia RK, Tickoo SC. Osteosarcoma of ethmoid sinus in an infant. Indian Pediatr 1993; 30 (02) 270-273
- 37 Kohanawa R, Tabuchi K, Okubo H, Nagata M, Hara A. Primary osteogenic sarcoma of the ethmoid sinus: a case report. Auris Nasus Larynx 2005; 32 (04) 411-413
- 38 Lee JA, Choi SY, Kang HJ. et al. Treatment outcome of osteosarcoma after bilateral retinoblastoma: a retrospective study of eight cases. Br J Ophthalmol 2014; 98 (10) 1355-1359
- 39 Lee KB, Ang ES, Tan KC. Reconstructive challenges in the management of a rare case of sphenoid osteosarcoma--a case report. Singapore Med J 2001; 42 (12) 586-589
- 40 Malalis JF, Lee JM, Jay WM. Primary osteosarcoma of the skull base in a pregnant patient. Neuroophthalmology 2013; 37 (01) 38-40
- 41 Mark RJ, Sercarz JA, Tran L, Dodd LG, Selch M, Calcaterra TC. Osteogenic sarcoma of the head and neck. The UCLA experience. Arch Otolaryngol Head Neck Surg 1991; 117 (07) 761-766
- 42 Mathkour M, Garces J, Beard B, Bartholomew A, Sulaiman OAR, Ware ML. Primary high-grade osteosarcoma of the clivus: a case report and literature review. World Neurosurg 2016; 89: 730.e9-730.e13
- 43 Oakley GM, Costa DJ, Mitchell RB, Sotelo C. Osteosarcoma of the skull base in a 15-year-old boy. Ear Nose Throat J 2011; 90 (10) 479-480
- 44 Okinaka Y, Takahashi M. Osteosarcoma of the maxilla: report of a case and review of the literature concerning metastasis. J Oral Maxillofac Surg 1997; 55 (10) 1177-1181
- 45 Papsidero MJ, Baker SR. Osteogenic sarcoma of the ethmoid sinus. Otolaryngol Head Neck Surg 1982; 90 (04) 510-512
- 46 Park H-R, Min SK, Cho HD. et al. Osteosarcoma of the ethmoid sinus. Skeletal Radiol 2004; 33 (05) 291-294
- 47 Park JU, Lee JH, Kim KH. Osteosarcoma of left maxillary sinus: a case report. J Oral Maxillofac Surg 2014; 72 (09) e164
- 48 Park Y-K, Ryu KN, Park H-R, Kim D-W. Low-grade osteosarcoma of the maxillary sinus. Skeletal Radiol 2003; 32 (03) 161-164
- 49 Santos-Silva AR, Ribeiro ACP, Furuse CF. et al. Maxillary osteosarcoma in a young patient undergoing postorthodontic treatment follow-up: the importance of ongoing oral examinations. Am J Orthod Dentofacial Orthop 2011; 139 (06) 845-848
- 50 Sargi Z, Cova D, Vernon SE. Pathology quiz case. Sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg 2008; 134 (12) 1343-1344 , 1344
- 51 Shahid H, Baharudin A, Halim AS, Biswal BM, Jihan WS. An extensive sinonasal osteosarcoma mimicking chondrosarcoma. Med J Malaysia 2007; 62 (02) 171-172
- 52 Sheikh S, Pallagatti S, Aggarwal A, Gupta D, Puri N, Mittal A. Osteosarcoma of maxilla: a case report. J Clin Exp Dent 2010; 2 (03) 177-120
- 53 Smith LM, Donaldson SS, Egbert PR, Link MP, Bagshaw MA. Aggressive management of second primary tumors in survivors of hereditary retinoblastoma. Int J Radiat Oncol Biol Phys 1989; 17 (03) 499-505
- 54 Smoron GL, Lennox AJ, McGee JL. Osteogenic sarcoma of the maxilla: neutron therapy for unresectable disease. Sarcoma 1999; 3 (02) 141-144
- 55 Stavrakas M, Nixon I, Andi K. et al. Head and neck sarcomas: clinical and histopathological presentation, treatment modalities, and outcomes. J Laryngol Otol 2016; 130 (09) 850-859
- 56 Tseng C-C, Lin C-Z, Li W-Y. Pathology quiz case 2. Postirradiation sinonasal osteosarcoma. Arch Otolaryngol Head Neck Surg 2005; 131 (02) 173 , 175–176
- 57 Uysal KM, Koyuncuoğlu M, Akman F. et al. A rare tumor of craniofacial bones in children: a pediatric chondroblastic osteosarcoma case with diagnostic and therapeutic problems. Pediatr Hematol Oncol 2001; 18 (02) 147-152
- 58 Vlychou M, Ostlere SJ, Kerr R, Athanasou NA. Low-grade osteosarcoma of the ethmoid sinus. Skeletal Radiol 2007; 36 (05) 459-462
- 59 Wei-wei L, Qiu-liang W, Guo-hao W, Zhi-hua C, Zong-yuan Z. Clinicopathologic features, treatment, and prognosis of postirradiation osteosarcoma in patients with nasopharyngeal cancer. Laryngoscope 2005; 115 (09) 1574-1579
- 60 Wolfowitz BL. Osteosarcoma and chondrosarcoma of the maxilla. J Laryngol Otol 1973; 87 (04) 409-416
- 61 Yamada SM, Ishii Y, Yamada S. et al. Skull base osteosarcoma presenting with cerebrospinal fluid leakage after CyberKnife treatment: a case report. J Med Case Reports 2013; 7: 116
- 62 Yamaguchi S, Nagasawa H, Suzuki T. et al. Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig 2004; 8 (02) 52-55
- 63 Patel AJ, Rao VY, Fox BD. et al. Radiation-induced osteosarcomas of the calvarium and skull base. Cancer 2011; 117 (10) 2120-2126
- 64 Friend SH, Bernards R, Rogelj S. et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323 (6089): 643-646
- 65 Hansen MF, Nellissery MJ, Bhatia P. Common mechanisms of osteosarcoma and Paget's disease. J Bone Miner Res 1999; 14 (Suppl. 02) 39-44
- 66 Hansen MF, Seton M, Merchant A. Osteosarcoma in Paget's disease of bone. J Bone Miner Res 2006; 21 (Suppl. 02) 58-63
- 67 Robinson E, Neugut AI, Wylie P. Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst 1988; 80 (04) 233-240
- 68 Cahan WG, Woodard HQ, Higinbotham NL, Stewart FW, Coley BL. Sarcoma arising in irradiated bone; report of 11 cases. Cancer 1948; 1 (01) 3-29
- 69 Arlen M, Higinbotham NL, Huvos AG, Marcove RC, Miller T, Shah IC. Radiation-induced sarcoma of bone. Cancer 1971; 28 (05) 1087-1099
- 70 Bertoni F, Dallera P, Bacchini P, Marchetti C, Campobassi A. The Istituto Rizzoli-Beretta experience with osteosarcoma of the jaw. Cancer 1991; 68 (07) 1555-1563
- 71 Caron AS, Hajdu SI, Strong EW. Osteogenic sarcoma of the facial and cranial bones. A review of forty-three cases. Am J Surg 1971; 122 (06) 719-725
- 72 Smith RB, Apostolakis LW, Karnell LH. et al. National cancer data base report on osteosarcoma of the head and neck. Cancer 2003; 98 (08) 1670-1680
- 73 Laskar S, Basu A, Muckaden MA. et al. Osteosarcoma of the head and neck region: lessons learned from a single-institution experience of 50 patients. Head Neck 2008; 30 (08) 1020-1026
- 74 Bernier J, Cooper JS, Pajak TF. et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 2005; 27 (10) 843-850