PDF herunterladen
Semin Plast Surg 2020; 34(01): 053-058
DOI: 10.1055/s-0039-3402517
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Applications of Fat Grafting in Pediatric Patients

Linden Shih
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Amjed Abu-Ghname
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Matthew J. Davis
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Amy S. Xue
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital, Houston, Texas
,
Robert F. Dempsey
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital, Houston, Texas
,
Edward P. Buchanan
1   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
2   Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital, Houston, Texas
› Institutsangaben Funding None of the authors has a financial interest in any of the drugs, devices, procedures, or companies mentioned in this article. The authors have nothing to disclose.
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
15. Februar 2020 (online)

Auch verfügbar auf
    Lizenzen und Reprints

Abstract

Autologous fat grafting has become a widely utilized technique for a variety of cosmetic and reconstructive procedures. Its potential for volume restoration and tissue regeneration has made it a popular method for treating soft tissue defects in both adult and pediatric populations. While autologous fat grafting in the pediatric setting is not as well characterized as it is in the adult setting, various reports have demonstrated the safety and utility of its applications in nonadult patient populations. In this article, we present the first comprehensive review of the current applications of autologous fat grafting in pediatric patients. Specific challenges to fat grafting in the pediatric setting and future applications will also be discussed.

Keywords

pediatric fat grafting - autologous fat grafting - pediatric lipofilling - volume restoration - congenital tissue deficiency - velopharyngeal insufficiency - scars
 

  • References

  • 1 Abu-Ghname A, Perdanasari AT, Reece EM. Principles and applications of fat grafting in plastic surgery. Semin Plast Surg 2019; 33 (03) 147-154
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Baptista C, Bertrand B, Philandrianos C, Degardin N, Casanova D. [Autologous fat grafting in children]. Ann Chir Plast Esthet 2016; 61 (05) 732-739
    CrossrefPubMedGoogle Scholar
  • 3 Grimaldi M, Gentile P, Labardi L, Silvi E, Trimarco A, Cervelli V. Lipostructure technique in Romberg syndrome. J Craniofac Surg 2008; 19 (04) 1089-1091
    CrossrefPubMedGoogle Scholar
  • 4 Jones CM, Morrow BT, Albright WB, Long RE, Samson TD, Mackay DR. Structural fat grafting to improve reconstructive outcomes in secondary cleft lip deformity. Cleft Palate Craniofac J 2017; 54 (01) 70-74
    CrossrefPubMedGoogle Scholar
  • 5 Sharma CM, Kumar S, Meghwani MK, Agrawal RP. Poland syndrome. Indian J Hum Genet 2014; 20 (01) 82-84
    CrossrefPubMedGoogle Scholar
  • 6 Panizza R, Ghiglione M, Zingarelli EM. , et al. Autologous fat grafting in the treatment of velopharyngeal insufficiency: Clinical outcomes and treatment tolerability survey in a case series of 21 patients. Indian J Plast Surg 2018; 51 (02) 145-154
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 7 Guibert M, Franchi G, Ansari E. , et al. Fat graft transfer in children's facial malformations: a prospective three-dimensional evaluation. J Plast Reconstr Aesthet Surg 2013; 66 (06) 799-804
    CrossrefPubMedGoogle Scholar
  • 8 Tringale KR, Lance S, Schoenbrunner A, Gosman AA. Sustained overcorrection after autologous facial fat grafting in the pediatric population: a case series. Ann Plast Surg 2017; 78 (05) (Suppl. 04) S217-S221
    CrossrefPubMedGoogle Scholar
  • 9 Garrocho-Rangel A, Manriquez-Olmos L, Flores-Velazquez J, Rosales-Berber M-A, Martinez-Rider R, Pozos-Guillen A. Non-syndromic craniosynostosis in children: Scoping review. Med Oral Patol Oral Cir Bucal 2018; 23 (04) e421-e428
    PubMedGoogle Scholar
  • 10 Castro-Govea Y, Vela-Martinez A, Treviño-Garcia LA. Volumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis. Arch Plast Surg 2018; 45 (02) 128-134
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 11 Governale LS. Craniosynostosis. Pediatr Neurol 2015; 53 (05) 394-401
    CrossrefPubMedGoogle Scholar
  • 12 Laurent F, Capon-Dégardin N, Martinot-Duquennoy V, Dhellèmmes P, Pellerin P. [Role of lipo-filling in the treatment of sequelae in craniosynostosis surgery]. Ann Chir Plast Esthet 2006; 51 (06) 512-516
    CrossrefPubMedGoogle Scholar
  • 13 Kalantar-Hormozi A, Abbaszadeh-Kasbi A, Kalantar-Hormozi H, Hosseinizadegan F, Davai NR. Role of autologous fat injection in neglected patients with anterior plagiocephaly. J Craniofac Surg 2019; 30 (07) e637-e639
    CrossrefPubMedGoogle Scholar
  • 14 Sinclair N, Gharb BB, Papay F, Rampazzo A. Soft tissue reconstruction in patients with hemifacial microsomia: a systematic review of the literature. J Craniofac Surg 2019; 30 (03) 879-887
    CrossrefPubMedGoogle Scholar
  • 15 Abduch LSF, Rocha PBD, Nasser IJG, Ono MCC, Freitas RDS. Dermal-fat graft for facial contouring in patients with craniofacial microsomia. J Craniofac Surg 2019; 30 (07) 2134-2137
    CrossrefPubMedGoogle Scholar
  • 16 Denadai R, Raposo-Amaral CA, Buzzo CL, Raposo-Amaral CE. Isolated autologous free fat grafting for management of facial contour asymmetry in a subset of growing patients with craniofacial microsomia. Ann Plast Surg 2016; 76 (03) 288-294
    CrossrefPubMedGoogle Scholar
  • 17 Tanna N, Wan DC, Kawamoto HK, Bradley JP. Craniofacial microsomia soft-tissue reconstruction comparison: inframammary extended circumflex scapular flap versus serial fat grafting. Plast Reconstr Surg 2011; 127 (02) 802-811
    CrossrefPubMedGoogle Scholar
  • 18 Tanikawa DYS, Aguena M, Bueno DF, Passos-Bueno MR, Alonso N. Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia. Plast Reconstr Surg 2013; 132 (01) 141-152
    PubMedGoogle Scholar
  • 19 Lim AA, Fan K, Allam KA. , et al. Autologous fat transplantation in the craniofacial patient: the UCLA experience. J Craniofac Surg 2012; 23 (04) 1061-1066
    CrossrefPubMedGoogle Scholar
  • 20 Rodby KA, Kaptein YE, Roring J. , et al. Evaluating autologous lipofilling for Parry–Romberg syndrome-associated defects: a systematic literature review and case report. Cleft Palate Craniofac J 2016; 53 (03) 339-350
    CrossrefPubMedGoogle Scholar
  • 21 Slack GC, Tabit CJ, Allam KA, Kawamoto HK, Bradley JP. Parry–Romberg reconstruction: beneficial results despite poorer fat take. Ann Plast Surg 2014; 73 (03) 307-310
    CrossrefPubMedGoogle Scholar
  • 22 Patel H, Thakkar C, Patel K. Parry–Romberg syndrome: a rare entity. J Maxillofac Oral Surg 2010; 9 (03) 247-250
    CrossrefPubMedGoogle Scholar
  • 23 Pagnoni M, Bartoli D, Terenzi V, Cassoni A, Valentini V, Iannetti G. Lipostructure in Parry–Romberg disease. J Craniofac Surg 2012; 23 (06) e621-e623
    CrossrefPubMedGoogle Scholar
  • 24 You KH, Baik HS. Orthopedic and orthodontic treatment of Parry–Romberg syndrome. J Craniofac Surg 2011; 22 (03) 970-973
    CrossrefPubMedGoogle Scholar
  • 25 Palmero MLH, Uziel Y, Laxer RM, Forrest CR, Pope E. En coup de sabre scleroderma and Parry–Romberg syndrome in adolescents: surgical options and patient-related outcomes. J Rheumatol 2010; 37 (10) 2174-2179
    PubMedGoogle Scholar
  • 26 Hu J, Yin L, Tang X, Gui L, Zhang Z. Combined skeletal and soft tissue reconstruction for severe Parry–Romberg syndrome. J Craniofac Surg 2011; 22 (03) 937-941
    CrossrefPubMedGoogle Scholar
  • 27 Hunstad JP, Shifrin DA, Kortesis BG. Successful treatment of Parry–Romberg syndrome with autologous fat grafting: 14-year follow-up and review. Ann Plast Surg 2011; 67 (04) 423-425
    CrossrefPubMedGoogle Scholar
  • 28 Stal S, Hollier L. Correction of secondary cleft lip deformities. Plast Reconstr Surg 2002; 109 (05) 1672-1681 , quiz 1682
    CrossrefPubMedGoogle Scholar
  • 29 Duskova M, Kristen M. Augmentation by autologous adipose tissue in cleft lip and nose. Final esthetic touches in clefts: part I. J Craniofac Surg 2004; 15 (03) 478-481 , discussion 482
    CrossrefPubMedGoogle Scholar
  • 30 Jones CM, Mackay DR. Autologous fat grafting in cleft lip and palate. J Craniofac Surg 2019; 30 (03) 686-691
    CrossrefPubMedGoogle Scholar
  • 31 Clauser L, Polito J, Mandrioli S, Tieghi R, Denes SA, Galiè M. Structural fat grafting in complex reconstructive surgery. J Craniofac Surg 2008; 19 (01) 187-191
    CrossrefPubMedGoogle Scholar
  • 32 Balkin DM, Samra S, Steinbacher DM. Immediate fat grafting in primary cleft lip repair. J Plast Reconstr Aesthet Surg 2014; 67 (12) 1644-1650
    CrossrefPubMedGoogle Scholar
  • 33 Zellner EG, Pfaff MJ, Steinbacher DM. Fat grafting in primary cleft lip repair. Plast Reconstr Surg 2015; 135 (05) 1449-1453
    CrossrefPubMedGoogle Scholar
  • 34 Koonce SL, Grant DG, Cook J, Stelnicki EJ. Autologous fat grafting in the treatment of cleft lip volume asymmetry. Ann Plast Surg 2018; 80 (6S): (Suppl. 06) S352-S355
    CrossrefPubMedGoogle Scholar
  • 35 Kennedy KR, Wang AL. Poland syndrome. N Engl J Med 2018; 378 (01) 72
    CrossrefPubMedGoogle Scholar
  • 36 Pinsolle V, Chichery A, Grolleau JL, Chavoin JP. Autologous fat injection in Poland's syndrome. J Plast Reconstr Aesthet Surg 2008; 61 (07) 784-791
    CrossrefPubMedGoogle Scholar
  • 37 Delay E, Sinna R, Chekaroua K, Delaporte T, Garson S, Toussoun G. Lipomodeling of Poland's syndrome: a new treatment of the thoracic deformity. Aesthetic Plast Surg 2010; 34 (02) 218-225
    CrossrefPubMedGoogle Scholar
  • 38 La Marca S, Delay E, Toussoun G, Ho Quoc C, Sinna R. Treatment of Poland syndrome thorax deformity with the lipomodeling technique: about ten cases. [in French]. Ann Chir Plast Esthet 2013; 58 (01) 60-68
    CrossrefPubMedGoogle Scholar
  • 39 Coudurier J, Ho Quoc C, Ismail M, Dlimi C, Tourasse C, Delay E. Évolution de la reconstruction mammaire par lipomodelage dans le syndrome de Poland: à propos d'un cas avec un recul de onze ans. Ann Chir Plast Esthet 2015; 60 (01) 65-69
    CrossrefPubMedGoogle Scholar
  • 40 Facchini F, Ghionzoli M, Martin A. , et al. Regenerative surgery in the treatment of cosmetic defect following nuss procedure. J Laparoendosc Adv Surg Tech A 2017; 27 (07) 748-753
    CrossrefPubMedGoogle Scholar
  • 41 Ho Quoc C, Delaporte T, Meruta A, La Marca S, Toussoun G, Delay E. Breast asymmetry and pectus excavatum improvement with fat grafting. Aesthet Surg J 2013; 33 (06) 822-829
    CrossrefPubMedGoogle Scholar
  • 42 Ho Quoc C, Foyatier JL, Meruta A, Piat JM, Michel G, Delay E. Lipofilling, an efficient solution for breast sequelae after cardiothoracic surgery. Ann Chir Plast Esthet 2015; 60 (06) 522-526
    CrossrefPubMedGoogle Scholar
  • 43 Clavijo-Alvarez JA, Wong A, Stofman G. Management of iatrogenic breast deformity after neonatal tube thoracostomy placement. Plast Reconstr Surg 2009; 123 (04) 155e-156e
    CrossrefPubMedGoogle Scholar
  • 44 Negenborn VL, Groen JW, Smit JM, Niessen FB, Mullender MG. The use of autologous fat grafting for treatment of scar tissue and scar-related conditions: a systematic review. Plast Reconstr Surg 2016; 137 (01) 31e-43e
    CrossrefPubMedGoogle Scholar
  • 45 Gal S, Ramirez JI, Maguina P. Autologous fat grafting does not improve burn scar appearance: A prospective, randomized, double-blinded, placebo-controlled, pilot study. Burns 2017; 43 (03) 486-489
    CrossrefPubMedGoogle Scholar
  • 46 Al-Hayder S, Gramkow C, Trojahn Kølle S-F. Use of autologous fat grafting for the correction of burn scar contracture in the hand: a case report. Case Reports Plast Surg Hand Surg 2017; 4 (01) 81-83
    PubMedGoogle Scholar
  • 47 Admani S, Gertner JW, Grosman A, Shumaker PR, Uebelhoer NS, Krakowski AC. Multidisciplinary, multimodal approach for a child with a traumatic facial scar. Semin Cutan Med Surg 2015; 34 (01) 24-27
    CrossrefPubMedGoogle Scholar
  • 48 Maione L, Memeo A, Pedretti L. , et al. Autologous fat graft as treatment of post short stature surgical correction scars. Injury 2014; 45 (Suppl. 06) S126-S132
    CrossrefPubMedGoogle Scholar
  • 49 Nigh E, Rubio GA, Hillam J, Armstrong M, Debs L, Thaller SR. Autologous fat injection for treatment of velopharyngeal insufficiency. J Craniofac Surg 2017; 28 (05) 1248-1254
    CrossrefPubMedGoogle Scholar
  • 50 Boneti C, Ray PD, Macklem EB, Kohanzadeh S, de la Torre J, Grant JH. Effectiveness and safety of autologous fat grafting to the soft palate alone. Ann Plast Surg 2015; 74 (Suppl. 04) S190-S192
    CrossrefPubMedGoogle Scholar
  • 51 Dejonckere PH, van Wijngaarden HA. Retropharyngeal autologous fat transplantation for congenital short palate: a nasometric assessment of functional results. Ann Otol Rhinol Laryngol 2001; 110 (02) 168-172
    CrossrefPubMedGoogle Scholar
  • 52 Leuchter I, Schweizer V, Hohlfeld J, Pasche P. Treatment of velopharyngeal insufficiency by autologous fat injection. Eur Arch Otorhinolaryngol 2010; 267 (06) 977-983
    CrossrefPubMedGoogle Scholar
  • 53 Piotet E, Beguin C, Broome M. , et al. Rhinopharyngeal autologous fat injection for treatment of velopharyngeal insufficiency in patients with cleft palate. Eur Arch Otorhinolaryngol 2015; 272 (05) 1277-1285
    CrossrefPubMedGoogle Scholar
  • 54 Cao Y, Ma T, Wu D, Yin N, Zhao Z. Autologous fat injection combined with palatoplasty and pharyngoplasty for velopharyngeal insufficiency and cleft palate: preliminary experience. Otolaryngol Head Neck Surg 2013; 149 (02) 284-291
    CrossrefPubMedGoogle Scholar
  • 55 Phua YS, Edmondson MJ, Kerr RJ, Macgill KA, Teixeira RP, Burge JA. Safety and efficacy concerns of autologous fat grafting for velopharyngeal insufficiency. Cleft Palate Craniofac J 2018; 55 (03) 383
    CrossrefPubMedGoogle Scholar