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Semin Respir Crit Care Med 2019; 40(05): 638-647
DOI: 10.1055/s-0039-1698379
DOI: 10.1055/s-0039-1698379
Review Article
Patient-Centered Outcomes in Critical Illness: Will My Patient Be Functionally and Cognitively Intact?
Funding Dr. Ferrante is supported by a Paul B. Beeson Emerging Leaders Career Development Award in Aging from the National Institute on Aging (K76 AG057023).Further Information
Publication History
Publication Date:
11 December 2019 (online)
Abstract
Survival in the intensive care unit (ICU) has steadily increased over the past several decades; millions of patients now survive a critical illness every year. ICU survivors are at a significantly increased risk of impairments in physical function, cognitive function, and mental health. These patient-centered outcomes are among the most meaningful to patients. Landmark studies concerning treatment preferences have demonstrated that patients value functional and cognitive outcomes over mortality. In this chapter, we discuss the determinants of functional and cognitive outcomes post critical illness to address the question, “Will my ICU patient be functionally and cognitively intact?”
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References
- 1 Needham DM, Davidson J, Cohen H. , et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med 2012; 40 (02) 502-509
- 2 Desai SV, Law TJ, Needham DM. Long-term complications of critical care. Crit Care Med 2011; 39 (02) 371-379
- 3 Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007; 33 (11) 1876-1891
- 4 Fan E, Dowdy DW, Colantuoni E. , et al. Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med 2014; 42 (04) 849-859
- 5 Puthucheary ZA, Rawal J, McPhail M. , et al. Acute skeletal muscle wasting in critical illness. JAMA 2013; 310 (15) 1591-1600
- 6 Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA 2007; 297 (16) 1772-1774
- 7 Gosselink R, Bott J, Johnson M. , et al. Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society Of Intensive Care Medicine Task Force on physiotherapy for critically ill patients. Intensive Care Med 2008; 34 (07) 1188-1199
- 8 Hermans G, Van den Berghe G. Clinical review: intensive care unit acquired weakness. Crit Care 2015; 19: 274
- 9 Stevens RD, Marshall SA, Cornblath DR. , et al. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 2009; 37 (10, Suppl): S299-S308
- 10 Jolley SE, Bunnell AE, Hough CL. ICU-acquired weakness. Chest 2016; 150 (05) 1129-1140
- 11 Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ. Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry 1984; 47 (11) 1223-1231
- 12 Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med 2013; 187 (03) 238-246
- 13 Bolton CF. Neuromuscular manifestations of critical illness. Muscle Nerve 2005; 32 (02) 140-163
- 14 Castro-Avila AC, Serón P, Fan E, Gaete M, Mickan S. Effect of early rehabilitation during intensive care unit stay on functional status: systematic review and meta-analysis. PLoS One 2015; 10 (07) e0130722
- 15 Ali NA, O'Brien Jr JM, Hoffmann SP. , et al; Midwest Critical Care Consortium. Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 2008; 178 (03) 261-268
- 16 Nordon-Craft A, Moss M, Quan D, Schenkman M. Intensive care unit-acquired weakness: implications for physical therapist management. Phys Ther 2012; 92 (12) 1494-1506
- 17 Hough CL, Lieu BK, Caldwell ES. Manual muscle strength testing of critically ill patients: feasibility and interobserver agreement. Crit Care 2011; 15 (01) R43
- 18 Puthucheary Z, Prescott H. Skeletal muscle weakness is associated with both early and late mortality after acute respiratory distress syndrome. Crit Care Med 2017; 45 (03) 563-565
- 19 Palakshappa JA, Reilly JP, Schweickert WD. , et al. Quantitative peripheral muscle ultrasound in sepsis: muscle area superior to thickness. J Crit Care 2018; 47: 324-330
- 20 Schuntermann M. International classification of functioning, disability and health (ICF) by WHO - short summary. Phys Med Rehabilmed Kurortmed 2001; 11 (06) 229-230
- 21 Garland A, Dawson NV, Altmann I. , et al; SUPPORT Investigators. Outcomes up to 5 years after severe, acute respiratory failure. Chest 2004; 126 (06) 1897-1904
- 22 Hopkins RO, Suchyta MR, Kamdar BB, Darowski E, Jackson JC, Needham DM. instrumental activities of daily living after critical illness: a systematic review. Ann Am Thorac Soc 2017; 14 (08) 1332-1343
- 23 Chelluri L, Im KA, Belle SH. , et al. Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 2004; 32 (01) 61-69
- 24 Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional trajectories among older persons before and after critical illness. JAMA Intern Med 2015; 175 (04) 523-529
- 25 Parry SM, Denehy L, Beach LJ, Berney S, Williamson HC, Granger CL. Functional outcomes in ICU – what should we be using? – an observational study. Crit Care 2015; 19: 127
- 26 Parry SM, Huang M, Needham DM. Evaluating physical functioning in critical care: considerations for clinical practice and research. Crit Care 2017; 21 (01) 249
- 27 Needham DM, Wozniak AW, Hough CL. , et al; National Institutes of Health NHLBI ARDS Network. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med 2014; 189 (10) 1214-1224
- 28 Parry SM, Granger CL, Berney S. , et al. Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties. Intensive Care Med 2015; 41 (05) 744-762
- 29 Denehy L, de Morton NA, Skinner EH. , et al. A physical function test for use in the intensive care unit: validity, responsiveness, and predictive utility of the physical function ICU test (scored). Phys Ther 2013; 93 (12) 1636-1645
- 30 Hodgson C, Needham D, Haines K. , et al. Feasibility and inter-rater reliability of the ICU Mobility Scale. Heart Lung 2014; 43 (01) 19-24
- 31 Corner EJ, Wood H, Englebretsen C. , et al. The Chelsea critical care physical assessment tool (CPAx): validation of an innovative new tool to measure physical morbidity in the general adult critical care population; an observational proof-of-concept pilot study. Physiotherapy 2013; 99 (01) 33-41
- 32 Corner EJ, Soni N, Handy JM, Brett SJ. Construct validity of the Chelsea critical care physical assessment tool: an observational study of recovery from critical illness. Crit Care 2014; 18 (02) R55
- 33 Zanni JM, Korupolu R, Fan E. , et al. Rehabilitation therapy and outcomes in acute respiratory failure: an observational pilot project. J Crit Care 2010; 25 (02) 254-262
- 34 Thrush A, Rozek M, Dekerlegand JL. The clinical utility of the functional status score for the intensive care unit (FSS-ICU) at a long-term acute care hospital: a prospective cohort study. Phys Ther 2012; 92 (12) 1536-1545
- 35 Guralnik JM, Simonsick EM, Ferrucci L. , et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49 (02) M85-M94
- 36 Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc 2006; 54 (05) 743-749
- 37 Needham DM, Dinglas VD, Morris PE. , et al; NIH NHLBI ARDS Network. Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 2013; 188 (05) 567-576
- 38 Herridge MS, Chu LM, Matte A. , et al; RECOVER Program Investigators (Phase 1: towards RECOVER); Canadian Critical Care Trials Group. The RECOVER Program: disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation. Am J Respir Crit Care Med 2016; 194 (07) 831-844
- 39 Iwashyna TJ. Trajectories of recovery and dysfunction after acute illness, with implications for clinical trial design. Am J Respir Crit Care Med 2012; 186 (04) 302-304
- 40 Iwashyna TJ, Hodgson CL, Pilcher D. , et al. Timing of onset and burden of persistent critical illness in Australia and New Zealand: a retrospective, population-based, observational study. Lancet Respir Med 2016; 4 (07) 566-573
- 41 Herridge MS. The challenge of designing a post-critical illness rehabilitation intervention. Crit Care 2011; 15 (05) 1002
- 42 Pfoh ER, Wozniak AW, Colantuoni E. , et al. Physical declines occurring after hospital discharge in ARDS survivors: a 5-year longitudinal study. Intensive Care Med 2016; 42 (10) 1557-1566
- 43 Broslawski GE, Elkins M, Algus M. Functional abilities of elderly survivors of intensive care. J Am Osteopath Assoc 1995; 95 (12) 712-717
- 44 Sacanella E, Pérez-Castejón JM, Nicolás JM. , et al. Functional status and quality of life 12 months after discharge from a medical ICU in healthy elderly patients: a prospective observational study. Crit Care 2011; 15 (02) R105
- 45 Jackson JC, Pandharipande PP, Girard TD. , et al; Bringing to light the Risk Factors And Incidence of Neuropsychological dysfunction in ICU survivors (BRAIN-ICU) study investigators. Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2014; 2 (05) 369-379
- 46 Haas JS, Teixeira C, Cabral CR. , et al. Factors influencing physical functional status in intensive care unit survivors two years after discharge. BMC Anesthesiol 2013; 13: 11
- 47 Quality of Life After Mechanized Ventilation in the Elderly Study Investigators. 2-month mortality and functional status of critically ill adult patients receiving prolonged mechanical ventilation. Chest 2002; 121 (02) 549-558
- 48 Cox CE, Carson SS, Lindquist JH, Olsen MK, Govert JA, Chelluri L. ; Quality of Life After Mechanical Ventilation in the Aged (QOL-MV) Investigators. Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. Crit Care 2007; 11 (01) R9
- 49 Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The association of frailty with post-ICU disability, nursing home admission, and mortality: a longitudinal study. Chest 2018; 153 (06) 1378-1386
- 50 Files DC, Neiberg R, Rushing J. , et al. Influence of prehospital function and strength on outcomes of critically ill older adults. J Am Geriatr Soc 2018; 66 (03) 525-531
- 51 Brummel NE, Girard TD, Ely EW. , et al. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med 2014; 40 (03) 370-379
- 52 Abelha FJ, Luís C, Veiga D. , et al. Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery. Crit Care 2013; 17 (05) R257
- 53 Solverson KJ, Grant C, Doig CJ. Assessment and predictors of physical functioning post-hospital discharge in survivors of critical illness. Ann Intensive Care 2016; 6 (01) 92
- 54 De Jonghe B, Sharshar T, Lefaucheur JP. , et al; Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002; 288 (22) 2859-2867
- 55 Griffiths RD, Palmer TEA, Helliwell T, MacLennan P, MacMillan RR. Effect of passive stretching on the wasting of muscle in the critically ill. Nutrition 1995; 11 (05) 428-432
- 56 Files DC, Liu C, Pereyra A. , et al. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med 2015; 7 (278) 278ra32
- 57 Inouye SK, Bogardus Jr ST, Charpentier PA. , et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999; 340 (09) 669-676
- 58 Mudge AM, Giebel AJ, Cutler AJ. Exercising body and mind: an integrated approach to functional independence in hospitalized older people. J Am Geriatr Soc 2008; 56 (04) 630-635
- 59 Bailey P, Thomsen GE, Spuhler VJ. , et al. Early activity is feasible and safe in respiratory failure patients. Crit Care Med 2007; 35 (01) 139-145
- 60 Thomsen GE, Snow GL, Rodriguez L, Hopkins RO. Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med 2008; 36 (04) 1119-1124
- 61 Morris PE, Goad A, Thompson C. , et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med 2008; 36 (08) 2238-2243
- 62 Nordon-Craft A, Schenkman M, Ridgeway K, Benson A, Moss M. Physical therapy management and patient outcomes following ICU-acquired weakness: a case series. J Neurol Phys Ther 2011; 35 (03) 133-140
- 63 Adler J, Malone D. Early mobilization in the intensive care unit: a systematic review. Cardiopulm Phys Ther J 2012; 23 (01) 5-13
- 64 Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active mobilization for mechanically ventilated patients: a systematic review. Arch Phys Med Rehabil 2013; 94 (03) 551-561
- 65 Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis. Crit Care Med 2013; 41 (06) 1543-1554
- 66 Hopkins RO, Spuhler VJ, Thomsen GE. Transforming ICU culture to facilitate early mobility. Crit Care Clin 2007; 23 (01) 81-96
- 67 Parker A, Sricharoenchai T, Needham DM. Early rehabilitation in the intensive care unit: preventing physical and mental health impairments. Curr Phys Med Rehabil Rep 2013; 1 (04) 307-314
- 68 Reid JC, Unger J, McCaskell D, Childerhose L, Zorko DJ, Kho ME. Physical rehabilitation interventions in the intensive care unit: a scoping review of 117 studies. J Intensive Care 2018; 6: 80
- 69 Schweickert WD, Pohlman MC, Pohlman AS. , et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009; 373 (9678): 1874-1882
- 70 Morris PE, Berry MJ, Files DC. , et al. Standardized rehabilitation and hospital length of stay among patients with acute respiratory failure: a randomized clinical trial. JAMA 2016; 315 (24) 2694-2702
- 71 Moss M, Nordon-Craft A, Malone D. , et al. A randomized trial of an intensive physical therapy program for patients with acute respiratory failure. Am J Respir Crit Care Med 2016; 193 (10) 1101-1110
- 72 Herridge MS, Tansey CM, Matté A. , et al; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011; 364 (14) 1293-1304
- 73 Cuthbertson BH. The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial (vol 339, b3723, 2009). BMJ 2009; b3723: 339
- 74 Walsh TS, Salisbury LG, Merriweather JL. , et al; RECOVER Investigators. Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the RECOVER Randomized Clinical Trial. JAMA Intern Med 2015; 175 (06) 901-910
- 75 Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL. The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med 2017; 43 (02) 171-183
- 76 Moher D, Liberati A, Tetzlaff J, Altman DG. ; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62 (10) 1006-1012
- 77 Slade SC, Dionne CE, Underwood M. , et al. Consensus on Exercise Reporting Template (CERT): modified Delphi study. Phys Ther 2016; 96 (10) 1514-1524
- 78 Schaller SJ, Anstey M, Blobner M. , et al; International Early SOMS-guided Mobilization Research Initiative. Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016; 388 (10052): 1377-1388
- 79 Connolly B, Denehy L, Hart N, Pattison N, Williamson P, Blackwood B. Physical Rehabilitation Core Outcomes In Critical illness (PRACTICE): protocol for development of a core outcome set. Trials 2018; 19 (01) 294
- 80 “Cognition”. In: APA Dictionary of Psychology. 2nd ed. Available at: https://dictionary.apa.org/cognition . Accessed August 22, 2019
- 81 Wolters AE, Slooter AJC, van der Kooi AW, van Dijk D. Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 2013; 39 (03) 376-386
- 82 Nedergaard HK, Jensen HI, Toft P. Interventions to reduce cognitive impairments following critical illness: a topical systematic review. Acta Anaesthesiol Scand 2017; 61 (02) 135-148
- 83 Jackson JC, Hart RP, Gordon SM. , et al. Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 2003; 31 (04) 1226-1234
- 84 Sakusic A, Rabinstein AA. Cognitive outcomes after critical illness. Curr Opin Crit Care 2018; 24 (05) 410-414
- 85 Oeyen S, Vermeulen K, Benoit D, Annemans L, Decruyenaere J. Development of a prediction model for long-term quality of life in critically ill patients. J Crit Care 2018; 43: 133-138
- 86 Hopkins PO, Weaver LK, Orme JF. , et al. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 2005; 172 (06) 786-787 , author reply 786–787
- 87 Sakusic A, Gajic O, Singh TD. , et al. Risk factors for persistent cognitive impairment after critical illness, nested case-control study. Crit Care Med 2018; 46 (12) 1977-1984
- 88 Ely EW, Gautam S, Margolin R. , et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001; 27 (12) 1892-1900
- 89 Pandharipande PP, Girard TD, Jackson JC. , et al; BRAIN-ICU Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369 (14) 1306-1316
- 90 Sakusic A, O'Horo JC, Dziadzko M. , et al. potentially modifiable risk factors for long-term cognitive impairment after critical illness: a systematic review. Mayo Clin Proc 2018; 93 (01) 68-82
- 91 Girard TD, Jackson JC, Pandharipande PP. , et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 2010; 38 (07) 1513-1520
- 92 Girard TD, Thompson JL, Pandharipande PP. , et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study. Lancet Respir Med 2018; 6 (03) 213-222
- 93 Kok L, Slooter AJ, Hillegers MH, van Dijk D, Veldhuijzen DS. Benzodiazepine use and neuropsychiatric outcomes in the ICU: a systematic review. Crit Care Med 2018; 46 (10) 1673-1680
- 94 Porhomayon J, Joude P, Adlparvar G, El-Solh AA, Nader ND. The impact of high versus low sedation dosing strategy on cognitive dysfunction in survivors of intensive care units: a systematic review and meta-analysis. J Cardiovasc Thorac Res 2015; 7 (02) 43-48
- 95 Shehabi Y, Bellomo R, Kadiman S. , et al; Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: a multinational prospective longitudinal cohort study. Crit Care Med 2018; 46 (06) 850-859
- 96 Brück E, Schandl A, Bottai M, Sackey P. The impact of sepsis, delirium, and psychological distress on self-rated cognitive function in ICU survivors-a prospective cohort study. J Intensive Care 2018; 6: 2
- 97 Davydow DS, Zatzick D, Hough CL, Katon WJ. In-hospital acute stress symptoms are associated with impairment in cognition 1 year after intensive care unit admission. Ann Am Thorac Soc 2013; 10 (05) 450-457
- 98 Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Presepsis depressive symptoms are associated with incident cognitive impairment in survivors of severe sepsis: a prospective cohort study of older Americans. J Am Geriatr Soc 2012; 60 (12) 2290-2296
- 99 Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010; 304 (16) 1787-1794
- 100 Guerra C, Linde-Zwirble WT, Wunsch H. Risk factors for dementia after critical illness in elderly Medicare beneficiaries. Crit Care 2012; 16 (06) R233
- 101 Semmler A, Widmann CN, Okulla T. , et al. Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors. J Neurol Neurosurg Psychiatry 2013; 84 (01) 62-69
- 102 Hopkins RO, Jackson JC. Short- and long-term cognitive outcomes in intensive care unit survivors. Clin Chest Med 2009; 30 (01) 143-153 , ix
- 103 Singer BH, Dickson RP, Denstaedt SJ. , et al. Bacterial dissemination to the brain in sepsis. Am J Respir Crit Care Med 2018; 197 (06) 747-756
- 104 Jackson JC, Ely EW, Morey MC. , et al. Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. Crit Care Med 2012; 40 (04) 1088-1097
- 105 Levine B, Stuss DT, Winocur G. , et al. Cognitive rehabilitation in the elderly: effects on strategic behavior in relation to goal management. J Int Neuropsychol Soc 2007; 13 (01) 143-152
- 106 Wassenaar A, Rood P, Boelen D, Schoonhoven L, Pickkers P, van den Boogaard M. Feasibility of cognitive training in critically ill patients: a pilot study. Am J Crit Care 2018; 27 (02) 124-135
- 107 Turon M, Fernandez-Gonzalo S, Jodar M. , et al. Feasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients. Ann Intensive Care 2017; 7 (01) 81