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CC BY-NC-ND 4.0 · Eur J Dent 2007; 01(01): 021-024
DOI: 10.1055/s-0039-1698307
Original Article
Dental Investigation Society

Fluoride Levels of Human Plasma and Breast Milk

Yağmur Şener
a   Selçuk University, Faculty of Dentistry, Department of Pedodontics
,
Gül Tosun
a   Selçuk University, Faculty of Dentistry, Department of Pedodontics
,
Firdevs Kahvecioğlu
b   Research Fellow, Selçuk University, Faculty of Dentistry, Department of Pedodontics
,
Alparslan Gökalp
c   Selçuk University, Faculty of Dentistry, Department of Pedodontics
,
Hasan Koç
d   Selçuk University, Faculty of Medicine, Department of Paediatrics
› Author Affiliations
Further Information

Publication History

Publication Date:
27 September 2019 (online)

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ABSTRACT

Objectives: The aim of this study was to determine the fluoride levels in breast milk and plasma of lactating mothers who regularly consumed drinking water with low levels of fluoride.

Methods: One hundred twenty five healthy mothers aged between 20-30 years old who had given birth within 5-7 days were included in the study. Besides being otherwise healthy, the primary selection criteria stipulated the absence of fluoride supplement consumption one month before delivery. Approximately 5 ml breast milk and 5 ml blood samples were obtained from each participating mother at a hospital setting, where the mothers were scheduled for a regular hospital diet. The blood samples were centrifuged in fluoride-free heparinized polyethylene tubes and stored at -18oC until measurements were made. Breast milk samples were directly refrigerated as with blood samples until measurements. The fluoride concentrations of milk and blood samples were assessed using an ion-selective fluoride electrode combined with an ion analyzer.

Results: The fluoride levels of the plasma and breast milk samples were measured as 0.017±0.011 ppm and 0.006±0.002 ppm, respectively. The fluoride concentration of plasma was significantly higher than that of breast milk (P<.01). Correlation analysis revealed a significant relation between the groups (P<.01).

Conclusion: A limited level of fluoride transmission from plasma to breast milk was detected. Nevertheless, a significant correlation between the fluoride concentrations of breast milk and plasma was evident. (Eur J Dent 2007;1:21-24)

Key words

Breast milk - Fluoride - Plasma
 

  • References

  • 1 Spak CJ, Hardell LI, De Chateau P. Fluoride in human milk.. Acta Paediatr Scand 1983; 72: 699-701
    CrossrefPubMedGoogle Scholar
  • 2 Ekstrand J, Spak CJ, Falch J, Afseth J, Ulvestad H. Distribution of fluoride to human breast milk.. Caries Res 1984; 18: 93-95
    CrossrefPubMedGoogle Scholar
  • 3 Rahul P, Hedge AM, Munshi AK. Estimation of the fluoride in human breast milk, cow’s milk and infant formulate.. J Clin Pediatr Dent 2003; 72: 257-260
    Google Scholar
  • 4 Mellberg JR, Ripa LW, Leske GS. Fluoride in Preventive Dentistry. Quintessence Publishing; Chicago: 1983: 0
    Google Scholar
  • 5 Whitford G. The Metabolism and Toxicity of Fluoride. 2nd ed. Switzerland: Karger; 1996: 0
    Google Scholar
  • 6 Fejerskov O, Ekstrand J, Burt BA. Fluoride in Dentistry.. 2nd ed. Copenhagen: Munsksgaard; 1996: 0
    Google Scholar
  • 7 World Health Organization Fluorides and oral health. Technical Report Series 846; Switzerland: 1994: 0
    Google Scholar
  • 8 Dabeka RW, Karpinski K, McKenzie A, Bajdik C. Survey of lead, cadmium and fluoride in human milk and correlation of levels with environmental and food factors. Food Chem Toxicol 1986; 24: 913-921
    CrossrefPubMedGoogle Scholar
  • 9 Fejerskow O, Manji F, Baelum V. The nature and mechanism of dental fluorosis in man. J Dent Res 1990; 69: 699-700
    Google Scholar
  • 10 Ekstrand J, Fomon SJ, Ziegler EZ, Nelson SE. Fluoride pharmacokinetics in infancy. Pediatr Res 1994; 35: 157-163
    CrossrefPubMedGoogle Scholar
  • 11 Sener Y, Koyuturk SE, Gokalp A. The fluoride levels of community water supplies in Konya city. The Journal of Hacettepe Faculty of Dentistry in Turkish 2003; 27: 2-6
    Google Scholar
  • 12 Brunette DM. Critical Thinking: Understanding and evaluating dental research.. 1st ed. Quintessence Publishing Co; Chicago: 1996: 0
    Google Scholar
  • 13 Greenhalgh R, Riley JP. The determination of fluoride in natural waters, with particular reference to sea water.. Anal Chim Acta 1961; 25: 179-188
    Google Scholar
  • 14 Fresen JA, Cox FH, Witter MJ. The determination of fluoride in biological materials by means of gas chromatography.. Pharm Weekbl 1968; 103: 909-914
    PubMedGoogle Scholar
  • 15 Yap AU, Tham SY, Zhu LY, Lee HK. Short-term fluoride release from various aesthetic restorative materials.. Oper Dent 2002; 27: 259-265
    PubMedGoogle Scholar
  • 16 Kahama RW, Damen JJ, ten Cate JM. Enzymatic release of sequestered cows’ milk fluoride for analysis by the hexamethyldisiloxane microdiffusion method.. Analyst 1997; 122: 855-858
    CrossrefPubMedGoogle Scholar
  • 17 Koparal E, Ertuğrul F, Öztekin K. Fluoride levels in breast milk and infant foods.. J Clin Pediatr Dent 2000; 24: 299-302
    PubMedGoogle Scholar
  • 18 World Health Organization Environmental Health Criteria 227; Geneva: 2002: 0
  • 19 Li Y, Liang CK, Katz BP, Brizendine EJ, Stookey GK. Longterm exposure to fluoride in drinking water and sisterchromatid exchange frequency in human blood lymphocytes.. J Dent Res 1995; 74: 1468-1474
    Google Scholar
  • 20 Latifah R, Razak IA. Fluoride levels in mother’s milk.. J Pedod 1989; 13: 149-154
    Google Scholar
  • 21 Ekstrand J, Boreus LO, Chateau Pde. No evidence of transfer of fluoride from plasma to breast milk. Br Med J 1981; 283: 761-762
    CrossrefPubMedGoogle Scholar