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DOI: 10.1055/s-0039-1694991
Transfusion-Associated Acute Lung Injury following Donor Granulocyte Transfusion in Two Pediatric Patients
Publication History
03 May 2019
06 July 2019
Publication Date:
26 August 2019 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029029/201904/lookinside/thumbnails/10-1055-s-0039-1694991_1900018-1.jpg)
Abstract
Transfusion-associated acute lung injury (TRALI) is one of the complications seen due to transfusion. Hypoxemia and bilateral pulmonary infiltration in posteroanterior chest roentgenogram is seen in all cases during transfusion or within the first 6 hours; fever, hypotension, and pink frothy bleeding from endotracheal tube may also be seen. It can be seen following the administration of any blood product. The management strategies for TRALI include withholding the transfusion, positive pressure breathing support, and diuretics. There are few reported cases of TRALI occurring following donor granulocyte transfusion (DGT). In this article, we discuss two cases of TRALI following DGT transfusion.
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References
- 1 Popovsky MA, Moore SB. Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion 1985; 25 (06) 573-577
- 2 Vlaar AP, Binnekade JM, Prins D. , et al. Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Crit Care Med 2010; 38 (03) 771-778
- 3 Looney MR, Roubinian N, Gajic O. , et al; Transfusion-Related Acute Lung Injury Study Group. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury. Crit Care Med 2014; 42 (07) 1676-1687
- 4 Bux J, Sachs UJ. The pathogenesis of transfusion-related acute lung injury (TRALI). Br J Haematol 2007; 136 (06) 788-799
- 5 Bux J. Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion. Vox Sang 2005; 89 (01) 1-10
- 6 Silliman CC, Kelher MR, Khan SY. , et al. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood 2014; 123 (22) 3488-3495
- 7 Kleinman S, Caulfield T, Chan P. , et al. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 2004; 44 (12) 1774-1789
- 8 Skeate RC, Eastlund T. Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload. Curr Opin Hematol 2007; 14 (06) 682-687
- 9 Gajic O, Rana R, Winters JL. , et al. Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med 2007; 176 (09) 886-891
- 10 Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest 2004; 126 (01) 249-258
- 11 Finlay HE, Cassorla L, Feiner J, Toy P. Designing and testing a computer-based screening system for transfusion-related acute lung injury. Am J Clin Pathol 2005; 124 (04) 601-609
- 12 Toy P, Gajic O, Bacchetti P. , et al; TRALI Study Group. Transfusion-related acute lung injury: incidence and risk factors. Blood 2012; 119 (07) 1757-1767
- 13 van Stein D, Beckers EA, Sintnicolaas K. , et al. Transfusion-related acute lung injury reports in the Netherlands: an observational study. Transfusion 2010; 50 (01) 213-220
- 14 Clifford L, Jia Q, Subramanian A, Yadav H, Schroeder DR, Kor DJ. Risk factors and clinical outcomes associated with perioperative transfusion-associated circulatory overload. Anesthesiology 2017; 126 (03) 409-418
- 15 Kuehnert MJ, Roth VR, Haley NR. , et al. Transfusion-transmitted bacterial infection in the United States, 1998 through 2000. Transfusion 2001; 41 (12) 1493-1499
- 16 Davenport RD. Pathophysiology of hemolytic transfusion reactions. Semin Hematol 2005; 42 (03) 165-168
- 17 Hirayama F. Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. Br J Haematol 2013; 160 (04) 434-444
- 18 Sachs UJ, Bux J. TRALI after the transfusion of cross-match-positive granulocytes. Transfusion 2003; 43 (12) 1683-1686
- 19 Stroncek DF, Leonard K, Eiber G, Malech HL, Gallin JI, Leitman SF. Alloimmunization after granulocyte transfusions. Transfusion 1996; 36 (11-12): 1009-1015