Download PDF
CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2019; 55(01): 014-017
DOI: 10.1055/s-0039-1694081
Review Article
National Academy of Medical Sciences (India)

Nanoceria and Its Biomedical Relevance

Jyotsna Kailashiya
1   Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
,
Debabrata Dash
1   Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

Publication Date:
02 October 2019 (online)

Also available at
   Permissions and Reprints

Abstract

Nanoceria is a nanosized particle preparation of cerium oxide. It shows mixture of cerium in the 3+ and 4+ states on the nanoparticle surface, giving it interesting redox properties. Nanoceria shows effective biological antioxidant properties, which makes it a great candidate for biomedical applications. Many studies have shown promising results on therapeutic potential of nanoceria in diseases like cancer, diabetes, atherosclerosis, and neurodegenerative diseases. Meanwhile, other studies explored biodistribution and toxicity of nanoceria. This review article describes nanoceria, its relevant biomedical applications, and adverse effects, based on previously reported studies.

Keywords

cerium oxide nanoparticles - antioxidant - reactive oxygen species - inflammatory diseases
 

  • References

  • 1 Dhall A, Self W. Cerium oxide nanoparticles: a brief review of their synthesis methods and biomedical applications. Antioxidants 2018; 7 (08) E97
    CrossrefPubMedGoogle Scholar
  • 2 Rajeshkumar S, Naik P. Synthesis and biomedical applications of Cerium oxide nanoparticles-A Review. Biotechnol Rep (Amst) 2017; 17: 1-5
    PubMedGoogle Scholar
  • 3 Xu C, Qu X. Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications. NPG Asia Materials 2014; 6 (03) e90
    CrossrefGoogle Scholar
  • 4 Caputo F, Mameli M, Sienkiewicz A. et al. A novel synthetic approach of cerium oxide nanoparticles with improved biomedical activity. Sci Rep. 2017 7. (1). Doi: 10.1038/s41598-017-04098-6
    PubMedGoogle Scholar
  • 5 Yokel RA, Hussain S, Garantziotis S, Demokritou P, Castranova V, Cassee FR. The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity. Environ Sci Nano 2014; 1 (05) 406-428
    CrossrefPubMedGoogle Scholar
  • 6 Naz S, Beach J, Heckert B. et al. Cerium oxide nanoparticles: a ‘radical’ approach to neurodegenerative disease treatment. Nanomedicine (Lond) 2017; 12 (05) 545-553
    Google Scholar
  • 7 Hegazy MAE, Maklad HM, Elmonsif DAA, Elnozhy FY, Alqubiea MA, Alenezi FA. The possible role of cerium oxide (CeO2) nanoparticles in prevention of neurobehavioral and neurochemical changes in 6-hydroxydopamineinduced parkinsonian disease. Alexandria Journal of Medicine 2017; 53 (04) 351-360
    CrossrefGoogle Scholar
  • 8 Pourkhalili N, Hosseini A, Nili-Ahmadabadi A. et al. Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats. World J Diabetes 2011; 2 (11) 204-210
    CrossrefPubMedGoogle Scholar
  • 9 Khurana A, Tekula S, Godugu C. Nanoceria suppresses multiple low doses of streptozotocin-induced Type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis. Nanomedicine (Lond) 2018; 13 (15) 1905-1922
    Google Scholar
  • 10 Chen J, Patil S, Seal S, McGinnis JF. Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol 2006; 1 (02) 142-150
    CrossrefPubMedGoogle Scholar
  • 11 Wang K, Mitra RN, Zheng M, Han Z. Nanoceria-loaded injectable hydrogels for potential age-related macular degeneration treatment. J Biomed Mater Res A 2018; 106 (11) 2795-2804
    CrossrefPubMedGoogle Scholar
  • 12 Kim J, Kim HY, Song SY. et al. Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite/ceria co-decorated nanoparticles for rheumatoid arthritis treatment. ACS Nano 2019; 13 (03) 3206-3217
    CrossrefPubMedGoogle Scholar
  • 13 Xue Y, St Hilaire C, Hortells L, Phillippi JA, Sant V, Sant S. Shape-specific nanoceria mitigate oxidative stress-induced calcification in primary human valvular interstitial cell culture. Cell Mol Bioeng 2017; 10 (05) 483-500
    CrossrefPubMedGoogle Scholar
  • 14 Kumari P, Saifi MA, Khurana A, Godugu C. Cardioprotective effects of nanoceria in a murine model of cardiac remodeling. J Trace Elem Med Biol 2018; 50: 198-208
    CrossrefPubMedGoogle Scholar
  • 15 Manne N, Arvapalli R, Graffeo VA. et al. Prophylactic treatment with cerium oxide nanoparticles attenuate hepatic ischemia reperfusion injury in sprague dawley rats. Cell Physiol Biochem 2017; 42 (05) 1837-1846
    CrossrefPubMedGoogle Scholar
  • 16 Saifi MA, Sangomla S, Khurana A, Godugu C. Protective effect of nanoceria on cisplatin-induced nephrotoxicity by amelioration of oxidative stress and pro-inflammatory mechanisms. Biol Trace Elem Res 2019; 189 (01) 145-156
    CrossrefPubMedGoogle Scholar
  • 17 Hirst SM, Karakoti A, Singh S. et al. Bio-distribution and in vivo antioxidant effects of cerium oxide nanoparticles in mice. Environ Toxicol 2013; 28 (02) 107-118
    CrossrefPubMedGoogle Scholar
  • 18 Niu J, Wang K, Kolattukudy PE. Cerium oxide nanoparticles inhibit oxidative stress and nuclear factor-κB activation in H9c2 cardiomyocytes exposed to cigarette smoke extract. J Pharmacol Exp Ther 2011; 338 (01) 53-61
    CrossrefPubMedGoogle Scholar
  • 19 Serebrovska Z, Swanson RJ, Portnichenko V. et al. Anti-inflammatory and antioxidant effect of cerium dioxide nanoparticles immobilized on the surface of silica nanoparticles in rat experimental pneumonia. Biomed Pharmacother 2017; 92: 69-77
    CrossrefPubMedGoogle Scholar
  • 20 Patel P, Kansara K, Singh R. et al. Cellular internalization and antioxidant activity of cerium oxide nanoparticles in human monocytic leukemia cells. Intl J Nanomed 2018; 13 (T-NANO 2014 Abstracts): 39-41
    Google Scholar
  • 21 Zhou X, Wang B, Chen Y, Mao Z, Gao C. Uptake of cerium oxide nanoparticles and their influences on functions of A549 cells. J Nanosci Nanotechnol 2013; 13 (01) 204-215
    CrossrefPubMedGoogle Scholar
  • 22 Xu C, Lin Y, Wang J. et al. Nanoceria-triggered synergetic drug release based on CeO(2) -capped mesoporous silica host-guest interactions and switchable enzymatic activity and cellular effects of CeO(2). Adv Healthc Mater 2013; 2 (12) 1591-1599
    CrossrefPubMedGoogle Scholar
  • 23 Sack M, Alili L, Karaman E. et al. Combination of conventional chemotherapeutics with redox-active cerium oxide nanoparticles—a novel aspect in cancer therapy. Mol Cancer Ther 2014; 13 (07) 1740-1749
    CrossrefPubMedGoogle Scholar
  • 24 Sack-Zschauer M, Bader S, Brenneisen P. Cerium oxide nanoparticles as novel tool in glioma treatment: an. Vitro study. J Nanomed Nanotechnol 2017; 8 (06) 474
    Google Scholar
  • 25 Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004; 56 (02) 185-229
    CrossrefPubMedGoogle Scholar
  • 26 Song HP, Jang JY, Bae SH, Choi SB, Yu BJ, Kim MI. Convenient colorimetric detection of thrombin via aptamer-mediated inhibition and restoration of the oxidase activity of nanoceria. J Nanosci Nanotechnol 2018; 18 (09) 6570-6574
    CrossrefPubMedGoogle Scholar
  • 27 Ni P, Xie J, Chen C. et al. Spectrophotometric determination of the activity of alkaline phosphatase and detection of its inhibitors by exploiting the pyrophosphate-accelerated oxidase-like activity of nanoceria. Mikrochim Acta 2019; 186 (05) 320
    CrossrefPubMedGoogle Scholar
  • 28 Liao H, Liu Y, Chen M, Wang M, Yuan H, Hu L. A colorimetric heparin assay based on the inhibition of the oxidase mimicking activity of cerium oxide nanoparticles. Mikrochim Acta 2019; 186 (05) 2741
    Google Scholar
  • 29 Collin B, Oostveen E, Tsyusko OV, Unrine JM. Influence of natural organic matter and surface charge on the toxicity and bioaccumulation of functionalized ceria nanoparticles in Caenorhabditis elegans. Environ Sci Technol 2014; 48 (02) 1280-1289
    CrossrefPubMedGoogle Scholar
  • 30 Könen-Adıgüzel S, Ergene S. In vitro evaluation of the genotoxicity of CeO2 nanoparticles in human peripheral blood lymphocytes using cytokinesis-block micronucleus test, comet assay, and gamma H2AX. Toxicol Ind Health 2018; 34 (05) 293-300
    CrossrefPubMedGoogle Scholar
  • 31 Eskandari N, Nejadi BabadaeiMM, Nikpur S. et al. Biophysical, docking, and cellular studies on the effects of cerium oxide nanoparticles on blood components: in vitro. Int J Nanomedicine 2018; 13: 4575-4589
    CrossrefPubMedGoogle Scholar
  • 32 Hussain S, Al-Nsour F, Rice AB. et al. Cerium dioxide nanoparticles induce apoptosis and autophagy in human peripheral blood monocytes. ACS Nano 2012; 6 (07) 5820-5829
    CrossrefPubMedGoogle Scholar
  • 33 Yokel RA, Tseng MT, Dan M. et al. Biodistribution and biopersistence of ceria engineered nanomaterials: size dependence. Nanomedicine (Lond) 2013; 9 (03) 398-407
    CrossrefPubMedGoogle Scholar
  • 34 Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Ali BH. The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice. Int J Nanomedicine 2017; 12: 2913-2922
    CrossrefPubMedGoogle Scholar
  • 35 Tseng MT, Lu X, Duan X. et al. Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria. Toxicol Appl Pharmacol 2012; 260 (02) 173-182
    CrossrefPubMedGoogle Scholar