CC BY 4.0 · Semin Liver Dis
DOI: 10.1055/s-0039-1693402
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Assessment and Management of Infection in Alcoholic Hepatitis

Nikhil Vergis
1  Department of Surgery & Cancer, Division of Digestive Diseases, Imperial College London, London, United Kingdom
,
Stephen R. Atkinson
1  Department of Surgery & Cancer, Division of Digestive Diseases, Imperial College London, London, United Kingdom
,
Mark R. Thursz
1  Department of Surgery & Cancer, Division of Digestive Diseases, Imperial College London, London, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
01 August 2019 (eFirst)

  

Abstract

Severe alcoholic hepatitis (SAH) is a condition characterized by jaundice and liver failure that develops after heavy and prolonged alcohol consumption. Infection frequently complicates the natural history of the disease and is independently associated with mortality. Objective recognition and recording of infection are therefore essential in the evaluation of therapeutic interventions and for antibiotic stewardship. This review will evaluate infections that complicate SAH at admission and beyond. Factors that associate with the development of infection will be identified and clinical and laboratory techniques available to identify infection will be discussed. Common pathogens and frequently used antibiotics will be reviewed and recommendations will be made for the management of infection for SAH patients. New techniques to assess infection earlier and more precisely may improve diagnosis and treatment of this important driver of mortality in SAH.