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Thromb Haemost 2019; 119(08): 1237-1246
DOI: 10.1055/s-0039-1692665
Theme Issue Article
Georg Thieme Verlag KG Stuttgart · New York

Heterogeneity of Macrophages in Atherosclerosis

Christopher Stremmel
1   Medizinische Klinik und Poliklinik I, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany
2   DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
,
Konstantin Stark
1   Medizinische Klinik und Poliklinik I, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany
2   DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
,
Christian Schulz
1   Medizinische Klinik und Poliklinik I, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany
2   DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
› Author Affiliations Funding C. Schulz and K.S. were supported by the CRC 1123 (project A07) funded by the DFG. C. Stremmel was supported by a Gerok position of the CRC 914 (project A10).
Further Information

Publication History

05 February 2019

13 May 2019

Publication Date:
26 June 2019 (online)

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Abstract

Atherosclerosis is a prevalent inflammatory condition and a frequent cause of morbidity and mortality worldwide. Macrophages are among the key immune cells driving lesion formation in the arterial wall. They have therefore evolved as potential targets for therapeutic strategies. Understanding of the different macrophage phenotypes and functions seems to be of pivotal importance for the development of treatments to target these immune cells. This review highlights the complexity of the mononuclear phagocyte system and summarizes important features of macrophage biology contributing to atherosclerosis.

Keywords

atherosclerosis - macrophage - monocyte - inflammation - therapy
 

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