Download PDF
CC BY-NC-ND 4.0 · Journal of Social Health and Diabetes 2019; 07(01): 006-010
DOI: 10.1055/s-0039-1692371
Review Article
Novo Nordisk Education Foundation

Effect on Insulin upon Storage in Extreme Climatic Conditions (Temperature and Pressure) and Their Preventive Measures

Girish Khurana
1   Department of Medicine, Vidya Medicare Centre, Bahadurgarh, India
,
Vipul Gupta‡
2   Department of Medicine, Gupta Ultrasound and Heart Care Centre, Paschim Vihar, New Delhi, India
› Author Affiliations
Further Information

Publication History

Publication Date:
28 June 2019 (online)

   Permissions and Reprints

Abstract

Insulin is a naturally occurring hormone secreted by the pancreas. Insulin is required by the body cellsto remove and use glucose from the blood. The insulin and its various analogues are essential in management of type 1 diabetes mellitus. This study has been done to analyze how variation in various storage conditions and climatic changes causes change in therapeutic efficacy. Storage condition affects the stability of insulin as observed in a study in which insulin stored at temperature between 32 and 37°C showed 14 to 18% decrease in its potency and could not cause a significant decrease in blood sugar level when compared with those receiving insulin stored at 5°C. This work was done with the aim of finding the effect of climatic changes and storage condition on efficacy of insulin.

Keywords

insulin - climatic changes - therapeutic efficacy
 

  • References

  • 1 Sonksen P, Sonksen J. Insulin: understanding its action in health and disease. Br J Anaesth 2000; 85 (01) 69-79
    CrossrefPubMedGoogle Scholar
  • 2 Koeslag JH, Saunders PT, Terblanche E. A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex. J Physiol 2003; 549 (Pt 2) 333-346
    CrossrefPubMedGoogle Scholar
  • 3 Ahmad K. Insulin sources and types: a review of insulin in terms of its mode on diabetes mellitus. J Tradit Chin Med 2014; 34 (02) 234-237
    CrossrefPubMedGoogle Scholar
  • 4 Camacho-Amor ML, Morales-Romo A, Calvo A. et al. [Evaluation of the cold chain during the national antipoliomyelitis vaccination days. Mexico, 1987-1988] [in Spanish] Salud Publica Mex 1990; 32 (01) 43-51
    PubMedGoogle Scholar
  • 5 Brown LH, Krumperman K, Fullagar CJ. Out-of-hospital medication storage temperatures: a review of the literature and directions for the future. Prehosp Emerg Care 2004; 8 (02) 200-206
    PubMedGoogle Scholar
  • 6 Grajower MM, Fraser CG, Holcombe JH. et al. How long should insulin be used once a vial is started?. Diabetes Care 2003; 26 (09) 2665-2666
    CrossrefPubMedGoogle Scholar
  • 7 Vimalavathini R, Gitanjali B. Effect of temperature on the potency & pharmacological action of insulin. Indian Journal of Medical Research 2009; 130 (02) 166-169
    PubMedGoogle Scholar
  • 8 Gregory R, Edwards S, Yateman NA. Demonstration of insulin transformation products in insulin vials by high-performance liquid chromatography. Diabetes Care 1991; 14 (01) 42-48
    PubMedGoogle Scholar
  • 9 Kumar KMP, Bhat GK. Animal insulins—current status. Int J Diabetes Dev Countries 2003; 23: 6-9
    Google Scholar
  • 10 Adams PS, Haines-Nutt RF, Town R. Stability of insulin mixtures in disposable plastic insulin syringes. J Pharm Pharmacol 1987; 39 (03) 158-163
    CrossrefPubMedGoogle Scholar
  • 11 Chandler C, Gryniewicz CM, Pringle T, Cunningham F. Insulin temperature and stability under simulated transit conditions. Am J Health Syst Pharm 2008; 65 (10) 953-963
    CrossrefPubMedGoogle Scholar
  • 12 Tarr BD, Campbell RK, Workman TM. Stability and sterility of biosynthetic human insulin stored in plastic insulin syringes for 28 days. Am J Hosp Pharm 1991; 48 (12) 2631-2634
    PubMedGoogle Scholar
  • 13 Insulin. Indian Pharmacopoeia. Ministry of Health and Family Welfare, Government of India. New Delhi, India: Controller of Publications; 1996: 399-401
    Google Scholar
  • 14 Yin W, Yuan Z, Tsutsumi K. et al. A lipoprotein lipase-promoting agent, NO-1886, improves glucose and lipid metabolism in high fat, high sucrose-fed New Zealand white rabbits. Int J Exp Diabesity Res 2003; 4 (01) 27-34
    CrossrefPubMedGoogle Scholar
  • 15 Georgiev IP, Kanelov IN, Dimitrova SS. et al. An experimental model for evaluation of glucose tolerance in rabbit. Bulg J Vet Med 2006; 9 (01) 27-35
    Google Scholar
  • 16 Pingel M, Vølund A. Stability of insulin preparations. Diabetes 1972; 21 (07) 805-813
    CrossrefPubMedGoogle Scholar
  • 17 Storvick WO, Henry HJ. Effect of storage temperature on stability of commercial insulin preparations. Diabetes 1968; 17 (08) 499-502
    CrossrefPubMedGoogle Scholar
  • 18 Arya SC. Insulin storage in a clay pot. Ann Saudi Med 2000; 20 (05) (06) 491-492
    PubMedGoogle Scholar
  • 19 Puepet FH, Mijinyawa BB, Akogu I. Insulin storage by patients with diabetes mellitus in Jos, Nigeria. J Med Trop 2007; 9 (01) 37-40
    Google Scholar
  • 20 Vimalavathini R, Agarwal SM, Gitanjali B. Educational program for patients with type-1 diabetes mellitus receiving free monthly supplies of insulin improves knowledge and attitude, but not adherence. Int J Diabetes Dev Ctries 2008; 28 (03) 86-90
    CrossrefPubMedGoogle Scholar
  • 21 Garry G. Storing Insulin—What's the Best Way to Store Insulin? [Internet]. [cited October 26, 2015]. Available at: http://type1diabetes.about.com/od/insulinandmedications/qt/insulin_storage.htm
    Google Scholar
  • 22 Strauss K, Gols HD, Hannet I, Partanen TM, Frid A. A pan-European epidemiologic study of insulin injection technique in patients with diabetes. Pract Diabetes Int 2002; 19 (03) 71-76
    CrossrefGoogle Scholar
  • 23 Nathan DM, Bayless M, Cleary P. et al; DCCT/EDIC Research Group. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes 2013; 62 (12) 3976-3986
    CrossrefPubMedGoogle Scholar
  • 24 Mullan RJ, Montori VM, Shah ND. et al. The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med 2009; 169 (17) 1560-1568
    PubMedGoogle Scholar
  • 25 Mokta JK, Kalra S. Insulin storage in the upper Himalayas. Rural Remote Health 2014; 14 (03) 2983
    PubMedGoogle Scholar
  • 26 Kalra S, Kalra B. Storage of insulin in rural areas. J Acad Med Scim 2012; 2: 88-89
    Google Scholar
  • 27 Kalra S, Gupta Y. Insulin technique. Sri Lanka J Diabetes Endocrinol Metab 2015; 5: 85-90
    CrossrefGoogle Scholar
  • 28 Tandon N, Kalra S, Balhara YP, Baruah MP, Chadha M, Chandalia HB. et al. Forum for injection technique (FIT), India: the Indian recommendations 2.0, for best practice in insulin injection technique, 2015. Indian J Endocrinol Metab 2015; 19: 317-331
    CrossrefPubMedGoogle Scholar