Synlett 2020; 31(08): 809-812
DOI: 10.1055/s-0039-1691595
letter
© Georg Thieme Verlag Stuttgart · New York

Iminyl-Radical-Mediated Cyanoalkylarylation of Activated Alkenes Enabled by Silver-Catalyzed Decarboxylation of α-Imino Oxy Acids

Zhi Wang
,
Xiaoyu Yan
,
Xiaoxue He
,
Xinhuan Yan
,
Xiaoqing Li
,
Xiangsheng Xu
This work was supported by the National Key Research and Development Program of China (2017YFC0210900).
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Publikationsverlauf

Received: 16. Dezember 2019

Accepted after revision: 22. Januar 2019

Publikationsdatum:
07. Februar 2020 (online)


Abstract

An iminyl-radical-mediated cyanoalkylarylation of α,β-unsaturated imides with cyclic α-imino oxy acids leading to isoquinoline-1,3(2H,4H)-dione derivatives has been developed. The procedure involves the generation of iminyl radicals through silver-catalyzed oxidative decarboxylation, followed by a C–C bond cleavage, cyanoalkylation, and C–H-functionalization cascade.

Supporting Information