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Synlett 2020; 31(09): 899-902
DOI: 10.1055/s-0039-1690856
DOI: 10.1055/s-0039-1690856
letter
O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups
This work was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI Grant Number 17K0821 to O.T.).Weitere Informationen
Publikationsverlauf
Received: 09. Januar 2020
Accepted after revision: 26. Februar 2020
Publikationsdatum:
13. März 2020 (online)
![](https://www.thieme-connect.de/media/synlett/202009/lookinside/thumbnails/st-2020-u0003-l_10-1055_s-0039-1690856-1.jpg)
Abstract
Amino groups are selectively protected in good yields by reaction with O-alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690856.
- Supporting Information
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References and Notes
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See also:
For a review, see:
See also: