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Synlett 2020; 31(04): 327-333
DOI: 10.1055/s-0039-1690792
DOI: 10.1055/s-0039-1690792
account
Development of a Divergent Route to Erythrina Alkaloids
We are grateful to the Innovationsfonden (Innovation Fund Denmark, Grant No. 7038-00149B) for generous support of this project.Further Information
Publication History
Received: 19 December 2019
Accepted after revision: 02 January 2020
Publication Date:
23 January 2020 (online)
Abstract
Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) – one of the most prominent members of this intriguing family of natural products.
1 Introduction
2 Synthetic Strategy
2.1 First Generation
2.2 Second Generation
2.3 Third Generation
2.3.1 Radical Endgame
2.3.2 Completion of the Total Synthesis
3 Conclusion
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