Synthesis 2019; 51(22): 4170-4182
DOI: 10.1055/s-0039-1690618
paper
© Georg Thieme Verlag Stuttgart · New York

Efficient Synthesis of Diverse 5-Thio- or 5-Selenotriazoles: One-Pot Multicomponent Reaction from Elemental Sulfur or Selenium

Lin-Lin Zhang
,
Ya-Ting Li
,
Ting Gao
,
Sha-Sha Guo
,
Bei Yang
,
Zi-Hui Meng
,
Qi-Pu Dai
,
Zhi-Bin Xu
,
Qin-Pei Wu
Weitere Informationen

Publikationsverlauf

Received: 17. Mai 2019

Accepted after revision: 06. August 2019

Publikationsdatum:
21. August 2019 (online)


Abstract

A sequential multistep reaction toward 5-thio- or 5-selenotriazoles has been established by generation of both copper(I) triazolides and sulfenylating or selenylating agents in situ, starting from elemental sulfur or selenium. This reaction features mild conditions, readily available and broad-scope substrates, good functional group compatibility, high efficiency and regioselectivity, easy operation, and ligand-free CuI.

Supporting Information