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DOI: 10.1055/s-0039-1688737
Do the New Hydrophilic Surface Have Any Influence on Early Success Rate and Implant Stability during Osseointegration Period? Four-Month Preliminary Results from a Split-Mouth, Randomized Controlled Trial
Publication History
Publication Date:
06 June 2019 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00042133/201901/lookinside/thumbnails/10-1055-s-0039-1688737_00017-1.jpg)
Abstract
Objective The objective of this study is to compare the implant stability of Hiossen ET III implants with its new hydrophilic (NH) surface and Hiossen ET III implants with the sandblasted and acid-etched (SA) surface.
Materials and Methods Patients required at least two teeth to be rehabilitated with a fixed, implant-supported restoration, consecutively enrolled. Patients randomly received SA surface implants (SA group) or SA implants with a newly developed bioabsorbable apatite nanocoating (NH group). Outcome measures were implant and prosthetic survival rate, complications, insertion torque, and implant stability quotient (ISQ) measured at implant placement and every week up to 8 weeks after implant placement. Comparison between groups was made by unpaired t-test, while the comparison between each follow-up will be made by paired t-tests to detect any change during the follow-up. Complications and failures were compared using Fisher's exact test.
Results A total of 14 patients were treated with 28 implants (14 SA and 14 NH). No implant and prosthesis failed 4 months after implant placement. No complications were experienced. At the 2nd week after implants placement, two implants in the SA group showed discontinuous measurements versus none in the NH group (p = 0.4815). Implants unscrewed during ISQ measurements and were rescrewed. Data recording stopped for 6 weeks. Both implants osseointegrated without any further complication. The NH implants did not show physiological ISQ decrease between 2nd and 4th week after implant placement, showing a more even pattern of ISQ values compared with SA implants (77.1 ± 4.6 vs. 72.9 ± 11.5; difference: 4.2 ± 12.1; p = 0.258). High ISQ values were found in both groups at each time point.
Conclusions NH implants are a viable alternative to SA surface, as they seem to avoid the ISQ drop during the remodeling phase.
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References
- 1 Cicciù M, Cervino G, Milone D, Risitano G. FEM investigation of the stress distribution over mandibular bone due to screwed overdenture positioned on dental implants. Materials (Basel) 2018; 11 (09) E1512
- 2 Cicciù M, Cervino G, Bramanti E. et al. FEM analysis of mandibular prosthetic overdenture supported by dental implants: evaluation of different retention methods. Comput Math Methods Med 2015; 2015: 943839
- 3 Bramanti E, Cervino G, Lauritano F. et al. FEM and Von Mises analysis on prosthetic crowns structural elements: evaluation of different applied materials. Sci World J 2017; 1-7 Article ID 1029574. Available at https://doi.org/10.1155/2017/1029574 Accessed on April 20, 2019
- 4 Cicciu M, Bramanti E, Matacena G, Guglielmino E, Risitano G. FEM evaluation of cemented-retained versus screw-retained dental implant single-tooth crown prosthesis. Int J Clin Exp Med 2014; 7 (04) 817-825
- 5 Cicciù M, Risitano G, Maiorana C, Franceschini G. Parametric analysis of the strength in the “Toronto” osseous-prosthesis system. Minerva Stomatol 2009; 58 (01) (02) 9-23
- 6 Yi YS, Emanuel KM, Chuang SK. Short (5.0 × 5.0 mm) implant placements and restoration with integrated abutment crowns. Implant Dent 2011; 20 (02) 125-130
- 7 Lauritano F, Runci M, Cervino G, Fiorillo L, Bramanti E, Cicciù M. Three-dimensional evaluation of different prosthesis retention systems using finite element analysis and the Von Mises stress test. Minerva Stomatol 2016; 65 (06) 353-367
- 8 Cervino G, Romeo U, Lauritano F. et al. Fem and von mises analysis of OSSTEM ® dental implant structural components: evaluation of different direction dynamic loads. Open Dent J 2018; 12: 219-229
- 9 Tallarico M, Vaccarella A, Marzi GC. Clinical and radiological outcomes of 1- versus 2-stage implant placement: 1-year results of a randomised clinical trial. Eur J Oral Implantology 2011; 4 (01) 13-20
- 10 Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 2007; 23 (07) 844-854
- 11 Glauser R, Sennerby L, Meredith N. et al. Resonance frequency analysis of implants subjected to immediate or early functional occlusal loading. Successful vs. failing implants. Clin Oral Implants Res 2004; 15 (04) 428-434
- 12 Toyoshima T, Wagner W, Klein MO, Stender E, Wieland M, Al-Nawas B. Primary stability of a hybrid self-tapping implant compared to a cylindrical non-self-tapping implant with respect to drilling protocols in an ex vivo model. Clin Implant Dent Relat Res 2011; 13 (01) 71-78
- 13 Renvert S, Polyzois I, Claffey N. How do implant surface characteristics influence peri-implant disease?. J Clin Periodontol 2011; 38 (Suppl. 11) 214-222
- 14 Dohan Ehrenfest DM, Coelho PG, Kang BS, Sul YT, Albrektsson T. Classification of osseointegrated implant surfaces: materials, chemistry and topography. Trends Biotechnol 2010; 28 (04) 198-206
- 15 Piattelli A, Cosci F, Scarano A, Trisi P. Localized chronic suppurative bone infection as a sequel of peri-implantitis in a hydroxyapatite-coated dental implant. Biomaterials 1995; 16 (12) 917-920
- 16 Payne AG, Tawse-Smith A, Duncan WD, Kumara R. Conventional and early loading of unsplinted ITI implants supporting mandibular overdentures. Clin Oral Implants Res 2002; 13 (06) 603-609
- 17 Cochran DL, Schenk RK, Lussi A, Higginbottom FL, Buser D. Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res 1998; 40 (01) 1-11
- 18 Khandelwal N, Oates TW, Vargas A, Alexander PP, Schoolfield JD, Alex McMahan C. Conventional SLA and chemically modified SLA implants in patients with poorly controlled type 2 diabetes mellitus--a randomized controlled trial. Clin Oral Implants Res 2013; 24 (01) 13-19
- 19 Lee JT, Cho SA. Biomechanical evaluation of laser-etched Ti implant surfaces vs. chemically modified SLA Ti implant surfaces: removal torque and resonance frequency analysis in rabbit tibias. J Mech Behav Biomed Mater 2016; 61: 299-307
- 20 Brånemark PI, Hansson BO, Adell R. et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 1977; 16: 1-132
- 21 Makary C, Rebaudi A, Sammartino G, Naaman N. Implant primary stability determined by resonance frequency analysis: correlation with insertion torque, histologic bone volume, and torsional stability at 6 weeks. Implant Dent 2012; 21 (06) 474-480
- 22 Szmukler-Moncler S, Salama H, Reingewirtz Y, Dubruille JH. Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature. J Biomed Mater Res 1998; 43 (02) 192-203
- 23 Lioubavina-Hack N, Lang NP, Karring T. Significance of primary stability for osseointegration of dental implants. Clin Oral Implants Res 2006; 17 (03) 244-250
- 24 Brånemark PI, Adell R, Breine U, Hansson BO, Lindström J, Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg 1969; 3 (02) 81-100
- 25 Junker R, Dimakis A, Thoneick M, Jansen JA. Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 2009; 20 (Suppl. 04) 185-206
- 26 Rupp F, Liang L, Geis-Gerstorfer J, Scheideler L, Hüttig F. Surface characteristics of dental implants: a review. Dent Mater 2018; 34 (01) 40-57
- 27 Heitz-Mayfield LJ. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol 2008; 35 (08) Suppl 292-304
- 28 Brett PM, Harle J, Salih V. et al. Roughness response genes in osteoblasts. Bone 2004; 35 (01) 124-133
- 29 Braceras I, Alava JI, Oñate JI. et al. Improved osseointegration in ion implantation-treated dental implants. Surf Coat Tech 2002; 158–159: 28-32
- 30 Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res 2007; 18 (04) 481-488
- 31 Long MW, Robinson JA, Ashcraft EA, Mann KG. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest 1995; 95 (02) 881-887
- 32 Reilly TM, Seldes R, Luchetti W, Brighton CT. Similarities in the phenotypic expression of pericytes and bone cells. Clin Orthop Relat Res 1998; (346) 95-103
- 33 Murphy M, Walczak MS, Thomas AG, Silikas N, Berner S, Lindsay R. Toward optimizing dental implant performance: surface characterization of Ti and TiZr implant materials. Dent Mater 2017; 33 (01) 43-53
- 34 Wennerberg A, Galli S, Albrektsson T. Current knowledge about the hydrophilic and nanostructured SLActive surface. Clin Cosmet Investig Dent 2011; 3: 59-67
- 35 Smeets R, Stadlinger B, Schwarz F. et al. Impact of dental implant surface modifications on osseointegration. BioMed Res Int 2016; 2016: 6285620