CC BY-NC-ND 4.0 · Eur J Dent 2019; 13(01): 036-041
DOI: 10.1055/s-0039-1688685
Original Article
Dental Investigation Society

Comparison of Salivary Calcium Level in Dentulous and Edentulous Patients

Maryam Rabiei
1   Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
,
Hamid Neshandar Asli
2   Department of Prostodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
,
Mohadeseh Haji Mohamadi
2   Department of Prostodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
› Author Affiliations
Further Information

Publication History

Publication Date:
06 June 2019 (online)

Abstract

Objectives Calcium is an inorganic component of the saliva, which is especially important in oral and dental health. This study sought to compare unstimulated salivary calcium level of dentulous and edentulous patients.

Materials and Methods This case–control study was conducted on 72 participants, including 36 dentulous and 36 edentulous patients. The unstimulated salivary flow rate of patients and the mean salivary calcium concentration were measured and compared. The data were analyzed using the nonparametric Mann–Whitney U-test.

Results The mean age of participants was 56.3 years. The mean number of teeth was 18.9 in the dentulous group. No significant difference was noted in salivary calcium level of dentulous and edentulous patients. The mean salivary calcium concentration was 0.61 ± 0.3875 mmol/L in dentulous and 0.8025 ± 0.5975 mmol/L in edentulous patients. Salivary calcium level had a significant inverse correlation with salivary flow rate (r = –0.370, p = 0.027), and by every 1-unit increase in salivary flow rate, salivary level of calcium significantly decreased by 3.85 units.

Conclusion Edentate had averagely higher salivary calcium level compared to dentulous. The salivary concentration of calcium ion is not correlated to the presence or absence of teeth. Salivary flow rate reduces the calcium concentration.

 
  • References

  • 1 Aliko A, Wolff A, Dawes C. et al. World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 120 (02) 185-206
  • 2 Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem 2018; 86: 23-70
  • 3 Khurshid Z, Zohaib S, Najeeb S, Zafar MS, Slowey PD, Almas K. Human saliva collection devices for proteomics: an update. Int J Mol Sci 2016; 17 6: E846
  • 4 Mohamed R, Campbell JL, Cooper-White J, Dimeski G, Punyadeera C. The impact of saliva collection and processing methods on CRP, IgE, and myoglobin immunoassays. Clin Transl Med 2012; 1 (01) 19
  • 5 Singh R, Pallagatti S, Sheikh S, Singh B, Arora G, Aggarwal A. Correlation of serum oestrogen with salivary calcium in post-menopausal women with and without oral dryness feeling. Gerodontology 2012; 29 (02) 125-129
  • 6 Agha-Hosseini F, Mirzaii-Dizgah I, Moosavi MS. Relationship of serum and saliva calcium, phosphorus and alkaline phosphatase with dry mouth feeling in menopause. Gerodontology 2012; 29 (02) e1092-e1097
  • 7 Liu J, Duan Y. Saliva: a potential media for disease diagnostics and monitoring. Oral Oncol 2012; 48 (07) 569-577
  • 8 Ahmadi-Motamayel F, Goodarzi MT, Hendi SS, Abdolsamadi H, Rafieian N. Evaluation of salivary flow rate, pH, buffering capacity, calcium and total protein levels in caries free and caries active adolescence. J Dent Oral Hyg 2013; 5 (04) 35-39
  • 9 Matsuo S, Lagerlöf F. Relationship between total and ionized calcium concentrations in human whole saliva and dental plaque fluid. Arch Oral Biol 1991; 36 (07) 525-527
  • 10 Kavanagh DA, Svehla G. Variation of salivary calcium, phosphate and buffering capacity in adolescents. Arch Oral Biol 1998; 43 (12) 1023-1027
  • 11 Anderson P, Hector MP, Rampersad MA. Critical pH in resting and stimulated whole saliva in groups of children and adults. Int J Paediatr Dent 2001; 11 (04) 266-273
  • 12 Dawes C. What is the critical pH and why does a tooth dissolve in acid?. J Can Dent Assoc 2003; 69 (11) 722-724
  • 13 Rabiei M, Masooleh IS, Leyli EK, Nikoukar LR. Salivary calcium concentration as a screening tool for postmenopausal osteoporosis. Int J Rheum Dis 2013; 16 (02) 198-202
  • 14 Dawes C. Salivary flow patterns and the health of hard and soft oral tissues. J Am Dent Assoc 2008; 139 (Suppl) 18S-24S
  • 15 Sewón LA, Karjalainen SM, Söderling E, Lapinleimu H, Simell O. Associations between salivary calcium and oral health. J Clin Periodontol 1998; 25 (11) Pt 1 915-919
  • 16 Khan RS, Khurshid Z, Yahya Ibrahim Asiri F. Advancing point-of-care (PoC) testing using human saliva as liquid biopsy. Diagnostics (Basel) 2017; 7 (03) E39
  • 17 Aro K, Wei F, Wong DT, Tu M. Saliva liquid biopsy for point-of-care applications. Front Public Health 2017; 5: 77
  • 18 Khurshid Z. Salivary point-of-care technology. Eur J Dent 2018; 12 (01) 1-2
  • 19 Maier H, Triebel C, Heidland A. The flow-rate-dependent excretion of ionized calcium in pilocarpine-stimulated human submandibular saliva. Arch Oral Biol 1983; 28 (10) 907-909
  • 20 Singh B, Sheikh S, Pallagatti S, Kaur K, Sohi R. Evaluation of salivary calcium and salivary parathyroid levels in postmenopausal women with and without oral dryness. Contemp Clin Dent 2013; 4 (04) 488-492
  • 21 Agha-Hosseini F, Mirzaii-Dizgah I, Moghaddam PP, Akrad ZT. Stimulated whole salivary flow rate and composition in menopausal women with oral dryness feeling. Oral Dis 2007; 13 (03) 320-323
  • 22 Sewón L, Laine M, Karjalainen S, Leimola-Virtanen R, Hiidenkari T, Helenius H. The effect of hormone replacement therapy on salivary calcium concentrations in menopausal women. Arch Oral Biol 2000; 45 (03) 201-206
  • 23 Sewón L, Laine M, Karjalainen S, Doroguinskaia A, Lehtonen-Veromaa M. Salivary calcium reflects skeletal bone density of heavy smokers. Arch Oral Biol 2004; 49 (05) 355-358
  • 24 Sewón L, Mäkelä M. A study of the possible correlation of high salivary calcium levels with periodontal and dental conditions in young adults. Arch Oral Biol 1990; 35 (Suppl) 211S-212S
  • 25 Larsen MJ, Jensen AF, Madsen DM, Pearce EI. Individual variations of pH, buffer capacity, and concentrations of calcium and phosphate in unstimulated whole saliva. Arch Oral Biol 1999; 44 (02) 111-117