Download PDF
CC BY-NC-ND 4.0 · Eur J Dent 2019; 13(01): 124-128
DOI: 10.1055/s-0039-1688654
Review Article
Dental Investigation Society

Nuclear Magnetic Resonance Spectroscopy for Medical and Dental Applications: A Comprehensive Review

Komal Zia
1   Department of Oral Biology, Riyadh College of Dentistry and Pharmacy, Riyadh, Saudi Arabia
,
Talal Siddiqui
2   General Dental Practitioner, Karachi, Pakistan
,
Saqib Ali
3   Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
,
Imran Farooq
3   Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
,
Muhammad Sohail Zafar
4   Department of Restorative Dentistry, College of Dentistry, Taibah University, Madinah Munawwarah, Saudi Arabia
5   Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad, Pakistan
,
Zohaib Khurshid
6   Department of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia
› Author Affiliations
Further Information

Publication History

Publication Date:
06 June 2019 (online)

   Permissions and Reprints

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is one of the most significant analytical techniques that has been developed in the past few decades. A broad range of biological and nonbiological applications ranging from an individual cell to organs and tissues has been investigated through NMR. Various aspects of this technique are still under research, and many functions of the NMR are still pending a better understanding and acknowledgment. Therefore, this review is aimed at providing a general overview of the main principles, types of this technique, and the advantages and disadvantages of NMR spectroscopy. In addition, an insight into the current uses of NMR in the field of medicine and dentistry and ongoing developments of NMR spectroscopy for future applications has been discussed.

Keywords

dentistry - metabolism - multiple sclerosis - spectroscopy
 

  • References

  • 1 Moseley I. Recent developments in imaging techniques. Br Med J (Clin Res Ed) 1982; 284 6323 1141-1144
    CrossrefPubMedGoogle Scholar
  • 2 Grant DM, Harris RK. Encyclopedia of Nuclear Magnetic Resonance. Chichester, New York: John Wiley; 1996
    Google Scholar
  • 3 Sahibzada HA, Khurshid Z, Khan RS. et al. Salivary IL-8, IL-6 and TNF-α as potential diagnostic biomarkers for oral cancer. Diagnostics (Basel) 2017; 7 (02) E21
    CrossrefPubMedGoogle Scholar
  • 4 Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD, Rehman IU. Role of salivary biomarkers in oral cancer detection. Adv Clin Chem 2018; 86: 23-70
    CrossrefPubMedGoogle Scholar
  • 5 Zainuddin N, Karpukhina N, Law RV, Hill RG. Characterisation of a remineralising Glass Carbomer® ionomer cement by MAS-NMR spectroscopy. Dent Mater 2012; 28 (10) 1051-1058
    CrossrefPubMedGoogle Scholar
  • 6 Khurshid Z, Mali M, Naseem M, Najeeb S, Zafar MS. Human gingival crevicular fluids (GCF) proteomics: an overview. Dent J (Basel) 2017; 5 (01) pii E12
    Google Scholar
  • 7 Mohammed NR, Kent NW, Lynch RJ, Karpukhina N, Hill R, Anderson P. Effects of fluoride on in vitro enamel demineralization analyzed by 19F MAS-NMR. Caries Res 2013; 47 (05) 421-428
    CrossrefPubMedGoogle Scholar
  • 8 Keeler J. Understanding NMR Spectroscopy. Chichester: John Wiley & Sons; 2011
    Google Scholar
  • 9 Sørensen O, Eich G, Levitt MH, Bodenhausen G, Ernst R. Product operator formalism for the description of NMR pulse experiments. Prog Nucl Magn Reson Spectrosc 1984; 16: 163-192
    CrossrefGoogle Scholar
  • 10 Michal CA, Wehman JC, Jelinski LW. Deuterium quadrupole-coupling and chemical-shielding tensors in the model dipeptide glycylglycine monohydrochloride monohydrate. J Magn Reson B 1996; 111 (01) 31-39
    CrossrefPubMedGoogle Scholar
  • 11 Hore P. Nuclear Magnetic Resonance. Oxford, UK: Oxford University Press; 2015
    Google Scholar
  • 12 Akitt JW, Mann BE. NMR and Chemistry: An Introduction to Modern NMR Spectroscopy. 4th ed.. London, UK: CRC Press; 2000
    Google Scholar
  • 13 Robinson JN, Coy A, Dykstra R, Eccles CD, Hunter MW, Callaghan PT. Two-dimensional NMR spectroscopy in Earth's magnetic field. J Magn Reson 2006; 182 (02) 343-347
    CrossrefPubMedGoogle Scholar
  • 14 Dubinnyi MA, Lesovoy DM, Dubovskii PV, Chupin VV, Arseniev AS. Modeling of 31P-NMR spectra of magnetically oriented phospholipid liposomes: a new analytical solution. Solid State Nucl Magn Reson 2006; 29 (04) 305-311
    CrossrefPubMedGoogle Scholar
  • 15 Frydman L, Harwood JS. Isotropic spectra of half-integer quadrupolar spins from bidimensional magic-angle spinning NMR. J Am Chem Soc 1995; 117: 5367-5368
    CrossrefGoogle Scholar
  • 16 Knight MJ, Webber AL, Pell AJ. et al. Fast resonance assignment and fold determination of human superoxide dismutase by high-resolution proton-detected solid-state MAS NMR spectroscopy. Angew Chem Int Ed Engl 2011; 50 (49) 11697-11701
    CrossrefPubMedGoogle Scholar
  • 17 Davis PL, Crooks LE, Margulis AR, Kaufman L. Nuclear magnetic resonance imaging: current capabilities. West J Med 1982; 137 (04) 290-293
    PubMedGoogle Scholar
  • 18 ten Cate JM. Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention. Eur J Oral Sci 1997; 105 (05) Pt 2 461-465
    CrossrefPubMedGoogle Scholar
  • 19 Yesinowski JP, Mobley MJ. Fluorine-19 MAS-NMR of fluoridated hydroxyapatite surfaces. J Am Chem Soc 1983; 105: 6191-6193
    CrossrefGoogle Scholar
  • 20 Koutcher JA, Sawyer RC, Kornblith AB. et al. In vivo monitoring of changes in 5-fluorouracil metabolism induced by metho-trexate measured by 19F NMR spectroscopy. Magn Reson Med 1991; 19 (01) 113-123
    CrossrefPubMedGoogle Scholar
  • 21 Fischer C, Lussi A, Hotz P. [The cariostatic mechanisms of action of fluorides. A review]. Schweiz Monatsschr Zahnmed 1995; 105 (03) 311-317
    PubMedGoogle Scholar
  • 22 Caytan E, Remaud GS, Tenailleau E, Akoka S. Precise and accurate quantitative (13)C NMR with reduced experimental time. Talanta 2007; 71 (03) 1016-1021
    CrossrefPubMedGoogle Scholar
  • 23 Zainuddin N, Karpukhina N, Hill RG, Law RV. A long-term study on the setting reaction of glass ionomer cements by (27)Al MAS-NMR spectroscopy. Dent Mater 2009; 25 (03) 290-295
    CrossrefPubMedGoogle Scholar
  • 24 Chang AE, Matory YL, Dwyer AJ. et al. Magnetic resonance imaging versus computed tomography in the evaluation of soft tissue tumors of the extremities. Ann Surg 1987; 205 (04) 340-348
    CrossrefPubMedGoogle Scholar
  • 25 Hammer BE. Industrial applications of nuclear magnetic resonance. Sens Rev 1998; 18: 245-251
    CrossrefGoogle Scholar
  • 26 Duer Cambridge MJ. Introduction to Solid-State NMR Spectroscopy. Cambridge, UK: Wiley-Blackwell; 2005
    Google Scholar
  • 27 Pickard CJ, Mauri F. All-electron magnetic response with pseudopotentials: NMR chemical shifts. Phys Rev B Condens Matter Mater Phys 2001; 63: 245101
    CrossrefGoogle Scholar
  • 28 Lee A, Klinowski J, Marseglia E. Application of nuclear magnetic resonance spectroscopy to bone diagenesis. J Archaeol Sci 1995; 22: 257-262
    CrossrefGoogle Scholar
  • 29 Damadian R, Minkoff L, Goldsmith M, Stanford M, Koutcher J. Field focusing nuclear magnetic resonance (FONAR): visualization of a tumor in a live animal. Science 1976; 194 4272 1430-1432
    CrossrefPubMedGoogle Scholar
  • 30 Bhujwalla ZM, Shungu DC, Chatham JC, Wehrle JP, Glickson JD. Glucose metabolism in RIF-1 tumors after reduction in blood flow: an in vivo 13C and 31P NMR study. Magn Reson Med 1994; 32 (03) 303-309
    CrossrefPubMedGoogle Scholar
  • 31 Warren KE. NMR spectroscopy and pediatric brain tumors. Oncologist 2004; 9 (03) 312-318
    CrossrefPubMedGoogle Scholar
  • 32 Ackerman JJ, Bore PJ, Gadian DG, Grove TH, Radda GK. N.m.r. studies of metabolism in perfused organs. Philos Trans R Soc Lond B Biol Sci 1980; 289 1037 425-436
    CrossrefPubMedGoogle Scholar
  • 33 Anderson JH, Strandberg JD, Wong DF. et al. Multimodality correlative study of canine brain tumors. Proton magnetic resonance spectroscopy, positron emission tomography, and histology. Invest Radiol 1994; 29 (06) 597-605
    CrossrefPubMedGoogle Scholar
  • 34 Bhakoo KK, Williams IT, Williams SR, Gadian DG, Noble MD. Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J Neurochem 1996; 66 (03) 1254-1263
    PubMedGoogle Scholar
  • 35 Budinger TF. Image analysis in critical care medicine. Crit Care Med 1982; 10 (12) 835-840
    CrossrefPubMedGoogle Scholar
  • 36 Prosser HJ, Richards CP, Wilson AD. NMR spectroscopy of dental materials. II. The role of tartaric acid in glass-ionomer cements. J Biomed Mater Res 1982; 16 (04) 431-445
    CrossrefPubMedGoogle Scholar
  • 37 Pires RA, Nunes TG, Abrahams I, Hawkes GE. The role of aluminium and silicon in the setting chemistry of glass ionomer cements. J Mater Sci Mater Med 2008; 19 (04) 1687-1692
    CrossrefPubMedGoogle Scholar
  • 38 Bienek DR, Frukhtbeyn SA, Giuseppetti AA, Okeke UC, Skrtic D. Antimicrobial monomers for polymeric dental restoratives: cytotoxicity and physicochemical properties. J Funct Biomater 2018; 9 (01) E20
    CrossrefPubMedGoogle Scholar
  • 39 Khurshid Z, Zohaib S, Najeeb S, Zafar MS, Rehman R, Rehman IU. Advances of proteomic sciences in dentistry. Int J Mol Sci 2016; 17 (05) E728
    CrossrefPubMedGoogle Scholar
  • 40 Zhou J, Hu H, Huang R. A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption. Clin Chim Acta 2018; 478: 188-193
    CrossrefPubMedGoogle Scholar
  • 41 Duchemann B, Triba MN, Guez D. et al. Nuclear magnetic resonance spectroscopic analysis of salivary metabolome in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2016; 33 (01) 10-16
    PubMedGoogle Scholar
  • 42 Khurshid Z. Salivary point-of-care technology. Eur J Dent 2018; 12 (01) 1-2
    Article in Thieme ConnectPubMedGoogle Scholar