Semin Liver Dis 2019; 39(04): 463-475
DOI: 10.1055/s-0039-1688442
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Competing Endogenous RNAs in Hepatocellular Carcinoma—The Pinnacle of Rivalry

Abdelrahman Yousry Afify
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
,
Salma Abdulmaqsoud Ibrahim
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
,
Mennah Hisham Aldamsisi
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
,
Mai Saad Zaghloul
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
,
Nada El-Ekiaby
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
,
Ahmed Ihab Abdelaziz
1  School of Medicine, Newgiza University (NGU), Giza, Egypt
› Author Affiliations
Further Information

Publication History

Publication Date:
26 June 2019 (eFirst)

Abstract

The role of noncoding transcripts in gene expression is nowadays acknowledged to keep various diseases at bay—despite being referred to as “junk” DNA several years ago. Believed to be at the heart of multiple regulatory pathways, microRNAs (miRNAs) are small noncoding RNAs (ncRNAs) involved in posttranscriptional gene regulation. Recently, the discovery of ncRNAs that compete for shared miRNA pools has dimmed the light on the solo performance of miRNAs in genomic regulation. Indeed, several studies describe RNAs such as long noncoding RNAs, mRNAs, circular RNAs, pseudogenes, and viral RNAs as competing endogenous RNAs (ceRNAs) that sequester miRNAs, allowing for de-repression of downstream miRNA targets. Such integration between coding and noncoding transcripts forms complex ceRNA networks that when dysregulated lead to several diseases such as hepatocellular carcinoma. Here, the authors review perturbed ceRNA networks in hepatocellular carcinoma, describe the role of each in tumorigenesis, and discuss their various clinical implications.

Authors' Contribution

Afify A.Y., Ibrahim S.A., and Aldamsisi M.H. collected the data and wrote the manuscript. El-Ekiaby N., Saad Zaghloul M., and Abdelaziz A.I. revised and critically appraised the manuscript.