CC BY-NC-ND 4.0 · J Neurol Surg Rep 2019; 80(01): e14-e17
DOI: 10.1055/s-0039-1685213
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Intracranial Mature Teratoma in an Adult Patient: A Case Report

Dominik Romić
1   Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia
,
Marina Raguž
1   Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia
,
Petar Marčinković
1   Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia
,
Patricija Sesar
2   Department of Pathology and Cytology, University Hospital Dubrava, Zagreb, Croatia
,
Martina Špero
3   Department of Radiology, University Hospital Dubrava, Zagreb, Croatia
,
Zrinka Čolak Romić
4   Department of Neurology, University Hospital Dubrava, Zagreb, Croatia
,
Domagoj Dlaka
1   Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia
,
Darko Chudy
1   Department of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia
› Institutsangaben
Weitere Informationen

Publikationsverlauf

23. September 2018

18. Januar 2019

Publikationsdatum:
03. April 2019 (online)

Abstract

Introduction: Primary intracranial teratoma is a subtype of germ cell tumors, classified into three subtypes. They occur very rarely, with only several reported individual cases in adults.

Case Description We present a patient with an intermittent headache in the right frontal region. Magnetic resonance imaging (MRI) revealed a right sided high frontal parasagittal mass that compressed the falx, the right lateral ventricle, as well as the brain parenchyma. Patient underwent surgical treatment. Histopathological analysis described mature teratoma. Four months after the surgical treatment there were no signs of residual intracranial mass or relapse.

Discussion Primary intracranial teratoma in adults has a nonspecific clinical presentation. MRI reveals a solitary irregular mass with multilocularity and mixed signals derived from different tissues. The patients age, biochemical markers, and patohistological analysis are necessary to confirm the diagnosis.

Conclusion Teratoma treatment strategy still remains controversial. It includes radical resection whenever possible. Since the residual portion of mature teratoma may contain part of immature or malignant tissue, tumor recurrence after surgical removal is possible. Also, new tumor mass could occur at other sites intracranial after the initial one was removed. Thus, although patients usually recover, they should be followed-up for a long period of time.

Compliance with Ethical Standards

The patient has given an informed consent for participation in this paper.


 
  • References

  • 1 Georgiu C, Opincariu I, Cebotaru CL. , et al. Intracranial immature teratoma with a primitive neuroectodermal malignant transformation - case report and review of the literature. Rom J Morphol Embryol 2016; 57 (04) 1389-1395
  • 2 Liu Z, Lv X, Wang W. , et al. Imaging characteristics of primary intracranial teratoma. Acta Radiol 2014; 55 (07) 874-881
  • 3 Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y. Central nervous system germ cell tumors: a review of the literature. J Child Neurol 2018; 33 (09) 610-620
  • 4 Kim JM, Cheong JH, Yi HJ, Bak KH, Kim CH, Oh SJ. Metachronous germinoma after total removal of mature teratoma in the third ventricle: a case report. J Korean Med Sci 2002; 17 (02) 287-291
  • 5 Lee YH, Park EK, Park YS, Shim KW, Choi JU, Kim DS. Treatment and outcomes of primary intracranial teratoma. Childs Nerv Syst 2009; 25 (12) 1581-1587
  • 6 Agrawal M, Uppin MS, Patibandla MR. , et al. Teratomas in central nervous system: a clinico-morphological study with review of literature. Neurol India 2010; 58 (06) 841-846
  • 7 Zhao J, Wang H, Yu J, Zhong Y, Ge P. Cerebral falx mature teratoma with rare imaging in an adult. Int J Med Sci 2012; 9 (04) 269-273
  • 8 Dimov I, Tasić D, Stojanović I. , et al. Mature intracranial teratoma. Acta Fac Med Naiss 2013; 30 (02) 97-102
  • 9 Beschorner R, Schittenhelm J, Bueltmann E, Ritz R, Meyermann R, Mittelbronn M. Mature cerebellar teratoma in adulthood. Neuropathology 2009; 29 (02) 176-180
  • 10 Pećina-Slaus N, Niku Eva-Martić T, Beros V, Tomas D. Genetic alterations of E-cadherin and beta-catenin in germinoma and teratoma: report of two central nervous system cases. Pathol Oncol Res 2007; 13 (04) 370-374
  • 11 Sugimoto K, Nakahara I, Nishikawa M. Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. Neurosurgery 2002; 50 (03) 613-616 , discussion 616–617
  • 12 Janzarik WG, Müller K, Lübbert M. , et al. Occurrence of a germinoma 22 years after resection of a mature cerebral teratoma. J Neurooncol 2008; 88 (02) 217-219