Clin Colon Rectal Surg 2019; 32(04): 261-267
DOI: 10.1055/s-0039-1683908
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Treatment Strategies in Crohn's-Associated Rectovaginal Fistula

Michelle F. DeLeon
1   Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio
,
Tracy L. Hull
1   Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio
› Author Affiliations
Further Information

Publication History

Publication Date:
02 July 2019 (online)

Abstract

Rectovaginal fistula (RVF) is a rare, but dreaded complication of Crohn's disease (CD) that is exceedingly difficult to manage. Treatment algorithms range from observation and medical therapy to local surgical repair and proctectomy. The multitude of surgical options and lack of consensus between experts speak to the complexity and shortcomings encountered to correct this disease process surgically. The key to successful management of these fistulae therefore rests on a multidisciplinary approach between the patient, gastroenterologists, and surgeons, with open communication about expectations and goals of care. In this article, we review the management of CD-associated RVF with an emphasis on surgical technique.

 
  • References

  • 1 Fichera A, Zoccali M. ; Crohn's & Colitis Foundation of America, Inc. Guidelines for the surgical treatment of Crohn's perianal fistulas. Inflamm Bowel Dis 2015; 21 (04) 753-758
  • 2 Hannaway CD, Hull TL. Current considerations in the management of rectovaginal fistula from Crohn's disease. Colorectal Dis 2008; 10 (08) 747-755 , discussion 755–756
  • 3 Valente MA, Hull TL. Contemporary surgical management of rectovaginal fistula in Crohn's disease. World J Gastrointest Pathophysiol 2014; 5 (04) 487-495
  • 4 Szurowska E, Wypych J, Izycka-Swieszewska E. Perianal fistulas in Crohn's disease: MRI diagnosis and surgical planning: MRI in fistulizing perianal Crohn's disease. Abdom Imaging 2007; 32 (06) 705-718
  • 5 Sheedy SP, Bruining DH, Dozois EJ, Faubion WA, Fletcher JG. MR imaging of perianal Crohn disease. Radiology 2017; 282 (03) 628-645
  • 6 Sloots CE, Felt-Bersma RJ, Poen AC, Cuesta MA, Meuwissen SG. Assessment and classification of fistula-in-ano in patients with Crohn's disease by hydrogen peroxide enhanced transanal ultrasound. Int J Colorectal Dis 2001; 16 (05) 292-297
  • 7 Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 1982; 83 (02) 383-387
  • 8 Greenbloom SL, Steinhart AH, Greenberg GR. Combination ciprofloxacin and metronidazole for active Crohn's disease. Can J Gastroenterol 1998; 12 (01) 53-56
  • 9 Dejaco C, Harrer M, Waldhoer T, Miehsler W, Vogelsang H, Reinisch W. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. Aliment Pharmacol Ther 2003; 18 (11-12): 1113-1120
  • 10 Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980; 302 (18) 981-987
  • 11 Korelitz BI, Present DH. Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci 1985; 30 (01) 58-64
  • 12 Andreani SM, Dang HH, Grondona P, Khan AZ, Edwards DP. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum 2007; 50 (12) 2215-2222
  • 13 Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 1994; 39 (02) 374-380
  • 14 Sands BE, Anderson FH, Bernstein CN. , et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004; 350 (09) 876-885
  • 15 Sands BE, Blank MA, Patel K, van Deventer SJ. ; ACCENT II Study. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2004; 2 (10) 912-920
  • 16 Kaimakliotis P, Simillis C, Harbord M, Kontovounisios C, Rasheed S, Tekkis PP. A systematic review assessing medical treatment for rectovaginal and enterovesical fistulae in Crohn's disease. J Clin Gastroenterol 2016; 50 (09) 714-721
  • 17 González-Lama Y, Abreu L, Vera MI. , et al. Long-term oral tacrolimus therapy in refractory to infliximab fistulizing Crohn's disease: a pilot study. Inflamm Bowel Dis 2005; 11 (01) 8-15
  • 18 Tuxen PA, Castro AF. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum 1979; 22 (01) 58-62
  • 19 Nosti PA, Stahl TJ, Sokol AI. Surgical repair of rectovaginal fistulas in patients with Crohn's disease. Eur J Obstet Gynecol Reprod Biol 2013; 171 (01) 166-170
  • 20 Greenwald JC, Hoexter B. Repair of rectovaginal fistulas. Surg Gynecol Obstet 1978; 146 (03) 443-445
  • 21 Cohen JL, Stricker JW, Schoetz Jr DJ, Coller JA, Veidenheimer MC. Rectovaginal fistula in Crohn's disease. Dis Colon Rectum 1989; 32 (10) 825-828
  • 22 Tsang CB, Madoff RD, Wong WD. , et al. Anal sphincter integrity and function influences outcome in rectovaginal fistula repair. Dis Colon Rectum 1998; 41 (09) 1141-1146
  • 23 Hull TL, Fazio VW. Surgical approaches to low anovaginal fistula in Crohn's disease. Am J Surg 1997; 173 (02) 95-98
  • 24 Kodner IJ, Mazor A, Shemesh EI, Fry RD, Fleshman JW, Birnbaum EH. Endorectal advancement flap repair of rectovaginal and other complicated anorectal fistulas. Surgery 1993; 114 (04) 682-689 , discussion 689–690
  • 25 Ruffolo C, Scarpa M, Bassi N, Angriman I. A systematic review on advancement flaps for rectovaginal fistula in Crohn's disease: transrectal vs transvaginal approach. Colorectal Dis 2010; 12 (12) 1183-1191
  • 26 Sher ME, Bauer JJ, Gelernt I. Surgical repair of rectovaginal fistulas in patients with Crohn's disease: transvaginal approach. Dis Colon Rectum 1991; 34 (08) 641-648
  • 27 Hull TL, Bartus C, Bast J, Floruta C, Lopez R. Multimedia article. Success of episioproctotomy for cloaca and rectovaginal fistula. Dis Colon Rectum 2007; 50 (01) 97-101
  • 28 El-Gazzaz G, Hull T, Mignanelli E, Hammel J, Gurland B, Zutshi M. Analysis of function and predictors of failure in women undergoing repair of Crohn's related rectovaginal fistula. J Gastrointest Surg 2010; 14 (05) 824-829
  • 29 Athanasiadis S, Yazigi R, Köhler A, Helmes C. Recovery rates and functional results after repair for rectovaginal fistula in Crohn's disease: a comparison of different techniques. Int J Colorectal Dis 2007; 22 (09) 1051-1060
  • 30 Marchesa P, Hull TL, Fazio VW. Advancement sleeve flaps for treatment of severe perianal Crohn's disease. Br J Surg 1998; 85 (12) 1695-1698
  • 31 Cutait DE, Cutait R, Ioshimoto M, Hyppólito da Silva J, Manzione A. Abdominoperineal endoanal pull-through resection. A comparative study between immediate and delayed colorectal anastomosis. Dis Colon Rectum 1985; 28 (05) 294-299
  • 32 Byron Jr RL, Ostergard DR. Sartorius muscle interposition for the treatment of the radiation-induced vaginal fistula. Am J Obstet Gynecol 1969; 104 (01) 104-107
  • 33 Lefèvre JH, Bretagnol F, Maggiori L, Alves A, Ferron M, Panis Y. Operative results and quality of life after gracilis muscle transposition for recurrent rectovaginal fistula. Dis Colon Rectum 2009; 52 (07) 1290-1295
  • 34 Fürst A, Schmidbauer C, Swol-Ben J, Iesalnieks I, Schwandner O, Agha A. Gracilis transposition for repair of recurrent anovaginal and rectovaginal fistulas in Crohn's disease. Int J Colorectal Dis 2008; 23 (04) 349-353
  • 35 Wexner SD, Ruiz DE, Genua J, Nogueras JJ, Weiss EG, Zmora O. Gracilis muscle interposition for the treatment of rectourethral, rectovaginal, and pouch-vaginal fistulas: results in 53 patients. Ann Surg 2008; 248 (01) 39-43
  • 36 Rangnekar NP, Imdad Ali N, Kaul SA, Pathak HR. Role of the martius procedure in the management of urinary-vaginal fistulas. J Am Coll Surg 2000; 191 (03) 259-263
  • 37 McNevin MS, Lee PYH, Bax TW. Martius flap: an adjunct for repair of complex, low rectovaginal fistula. Am J Surg 2007; 193 (05) 597-599 , discussion 599
  • 38 Schwandner O, Fuerst A, Kunstreich K, Scherer R. Innovative technique for the closure of rectovaginal fistula using Surgisis mesh. Tech Coloproctol 2009; 13 (02) 135-140
  • 39 Schwandner O, Fuerst A. Preliminary results on efficacy in closure of transsphincteric and rectovaginal fistulas associated with Crohn's disease using new biomaterials. Surg Innov 2009; 16 (02) 162-168
  • 40 García-Arranz M, Herreros MD, González-Gómez C. , et al. Treatment of Crohn's-related rectovaginal fistula with allogeneic expanded-adipose derived stem cells: a phase I-IIa clinical trial. Stem Cells Transl Med 2016; 5 (11) 1441-1446