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Int J Angiol 2019; 28(01): 044-049
DOI: 10.1055/s-0038-1676836
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Exercise Training Improved Longitudinal Intrinsic Left Ventricle Function in Heart Failure with Preserved Ejection Fraction

Anwar Santoso
1   Department of Cardiology – Vascular Medicine, Faculty of Medicine – Universitas Indonesia, National Cardiovascular Centre – Harapan Kita Hospital, Jakarta, Indonesia
,
Sidhi Laksono Purwowiyoto
2   Department of Cardiology –Vascular Medicine, Pasar Rebo Hospital, Jakarta Timur, Indonesia
,
Budhi Setianto Purwowiyoto
1   Department of Cardiology – Vascular Medicine, Faculty of Medicine – Universitas Indonesia, National Cardiovascular Centre – Harapan Kita Hospital, Jakarta, Indonesia
,
Amiliana Mardiana Soesanto
1   Department of Cardiology – Vascular Medicine, Faculty of Medicine – Universitas Indonesia, National Cardiovascular Centre – Harapan Kita Hospital, Jakarta, Indonesia
› Author Affiliations
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Publication History

Publication Date:
08 January 2019 (online)

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Abstract

Exercise improves morbidity, fatality rate, and quality of life in heart failure with low ejection fraction, but fewer data available in heart failure with preserved ejection fraction (HFPEF).

The purpose of this study is to test the hypothesis that exercise training might improve the longitudinal intrinsic left ventricular (LV) function in HFPEF patients.

This quasi-experimental study had recruited 30 patients with HFPEF. Exercise training program had been performed for a month with a total of 20 times exercise sessions and evaluated every 2 weeks. Echocardiography was performed before sessions, second week and fourth week of exercise training. Six-minute walk tests (6MWTs) and quality-of-life variables using Minnesota living with HF scoring and the 5-item World Health Organization Well-Being Index scoring were measured before and after exercise as well.

Left ventricular filling pressure, represented by the ratio of early diastolic mitral flow velocity/early diastolic annular velocity and left atrial volume index, improved during exercise. The longitudinal intrinsic LV function, represented by four-chamber longitudinal strain, augmented during exercise (p < 0.001). Aerobic capacity, measured by 6MWT, increased significantly (p = 0.001). Quality of life improved significantly during exercise (p < 0.001).

Exercise training was suggested to improve the longitudinal intrinsic LV function and quality of life in HFPEF. Clinical Trial Registration: ACTRN12614001042639.

Keywords

heart failure with preserved ejection fraction - 6-minute walk test - four-chamber longitudinal strain - Minnesota living with heart failure
 

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