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Journal of Pediatric Epilepsy 2018; 07(03): 111-116
DOI: 10.1055/s-0038-1676539
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Reflection on Assessing the Development of Children after Epilepsy Surgery

Monique van Schooneveld
1   Sector of Neuropsychology, Department of Medical Psychology, Wilhelmina Children's Hospital, Utrecht, The Netherlands
,
Aag Jennekens-Schinkel
2   Department of Child Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
› Author Affiliations
Further Information

Publication History

14 May 2018

03 November 2018

Publication Date:
18 December 2018 (online)

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Abstract

Children of schoolage having similar medical and neuropsychological conditions but entirely different life courses after left-sided hemispherectomy led us to reflect on sources of differences in development after epilepsy surgery. Two recent reviews exposed the impact of epilepsy-related variables on the cognitive outcomes and concluded that overall the surgical procedures had not caused additional harm. Our aim was to see whether facilitating or impeding influences—other than epilepsy and epilepsy surgery—were addressed in the literature regarding cognitive outcome. Further review of the literature did not yield information on influences of variables that are known to affect normal development; no study addressed influences of motor and/or sensory impairments. Few studies discussed interference of deficits in other cognitive domains with the target domains. The influences of gender and of an important environmental aspect, family factors, etc., were underexposed as well. Understanding why one child adjusts to her/his novel life situation and another child with apparently similar abilities and impairments is unable to do so, is essential for adequate counseling. A more biographical approach of cognitive development is proposed to understand the differential life courses of children and adolescents with a history of epilepsy surgery. A perspective of “functioning” rather than cognitive “functions,” conceived of as independent entities, will help bridge the gap between neurocognitive and more biographical approaches to the functioning of children after epilepsy surgery.

Keywords

children - cognitive outcome - development - epilepsy surgery
 

  • References

  • 1 Ryvlin P, Cross JH, Rheims S. Epilepsy surgery in children and adults. Lancet Neurol 2014; 13 (11) 1114-1126
    CrossrefPubMedGoogle Scholar
  • 2 Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurol 2008; 7 (06) 525-537
    CrossrefPubMedGoogle Scholar
  • 3 Van Schooneveld MM, Braun KP. Cognitive outcome after epilepsy surgery in children. Brain Dev 2013; 35 (08) 721-729
    CrossrefPubMedGoogle Scholar
  • 4 Flint AE, Waterman M, Bowmer G, Vadlamani G, Chumas P, Morrall MCHJ. Neuropsychological outcomes following paediatric temporal lobe surgery for epilepsies: evidence from a systematic review. Seizure 2017; 52: 89-116
    CrossrefPubMedGoogle Scholar
  • 5 Ramantani G, Reuner G. Cognitive development in pediatric epilepsy surgery. Neuropediatrics 2018; 49 (02) 93-103
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Ronen GM, Streiner DL, Boyle MH. , et al; QUALITÉ Group. Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study. Pediatr Neurol 2014; 50 (01) 38-48
    CrossrefPubMedGoogle Scholar
  • 7 Roulet-Perez E, Davidoff V, Mayor-Dubois C. , et al. Impact of severe epilepsy on development: recovery potential after successful early epilepsy surgery. Epilepsia 2010; 51 (07) 1266-1276
    CrossrefPubMedGoogle Scholar
  • 8 Libertus K, Hauf P. Editorial: motor skills and their foundational role for perceptual, social, and cognitive development. Front Psychol 2017; 8: 301
    CrossrefPubMedGoogle Scholar
  • 9 Schmidt M, Egger F, Benzing V. , et al. Disentangling the relationship between children's motor ability, executive function and academic achievement. PLoS One 2017; 12 (08) e0182845
    CrossrefPubMedGoogle Scholar
  • 10 Mayberry RI. Cognitive development in deaf children: the interface of language and perception in neuropsychology. In: Segalowitz SJ, ed. Handbook of Neuropsychology, 2nd ed. Vol. 8, Part II. Amsterdam, The Netherlands: Elsevier Science BV; 2002: 71-107
  • 11 Gordon K, Henkin Y, Kral A. Asymmetric hearing during development: the aural preference syndrome and treatment options. Pediatrics 2015; 136 (01) 141-153
    CrossrefPubMedGoogle Scholar
  • 12 Vernon PA. Speed of information processing and general intelligence. Intell 1983; 7 (01) 53-70
    PubMedGoogle Scholar
  • 13 Kail R, Salthouse TA. Processing speed as a mental capacity. Acta Psychol 1994; 86 (2, 3): 199-225
    CrossrefPubMedGoogle Scholar
  • 14 Palejwala MH, Fine JG. Gender differences in latent cognitive abilities in children aged 2 to 7. Intell 2015; 48: 96-108
    PubMedGoogle Scholar
  • 15 Cserjesi R, VAN Braeckel KN, Timmerman M. , et al. Patterns of functioning and predictive factors in children born moderately preterm or at term. Dev Med Child Neurol 2012; 54 (08) 710-715
    CrossrefPubMedGoogle Scholar
  • 16 Eriksen W, Sundet JM, Tambs K. Are stepfathers' education levels associated with the intelligence of their stepsons? A register-based study of Norwegian half-brothers. Br J Psychol 2013; 104 (02) 212-224
    CrossrefPubMedGoogle Scholar
  • 17 Puka K, Khattab M, Kerr EN, Smith ML. Academic achievement one year after resective epilepsy surgery in children. Epilepsy Behav 2015; 47: 1-5
    CrossrefPubMedGoogle Scholar
  • 18 Puka K, Rubinger L, Chan C, Smith ML, Widjaja E. Predictors of intellectual functioning after epilepsy surgery in childhood: the role of socioeconomic status. Epilepsy Behav 2016; 62: 35-39
    CrossrefPubMedGoogle Scholar
  • 19 Puka K, Smith ML. Remembrance and time passed: memory outcomes 4–11 years after pediatric epilepsy surgery. Epilepsia 2016; 57 (11) 1798-1807
    CrossrefPubMedGoogle Scholar
  • 20 Puka K, Smith ML. Predictors of language skills in the long term after pediatric epilepsy surgery. Epilepsy Behav 2016; a; 63: 1-8
    CrossrefPubMedGoogle Scholar
  • 21 Puka K, Smith ML. Academic skills in the long term after epilepsy surgery in childhood. Epilepsy Behav 2016; b; 62: 97-103
    CrossrefPubMedGoogle Scholar
  • 22 Puka K, Smith ML. Where are they now? Psychosocial, educational, and vocational outcomes after epilepsy surgery in childhood. Epilepsia 2016; c; 57 (04) 574-581
    CrossrefPubMedGoogle Scholar
  • 23 Puka K, Tavares TP, Smith ML. Development of intelligence 4 to 11 years after paediatric epilepsy surgery. J Neuropsychol 2017; 11 (02) 161-173
    CrossrefPubMedGoogle Scholar
  • 24 Save-Pédebos J, Pinabiaux C, Dorfmuller G. , et al. The development of pragmatic skills in children after hemispherotomy: contribution from left and right hemispheres. Epilepsy Behav 2016; 55: 139-145
    CrossrefPubMedGoogle Scholar
  • 25 Meekes J, Braams O, Braun KP, Jennekens-Schinkel A, van Nieuwenhuizen O. ; Dutch Collaborative Epilepsy Surgery Programme (DuCESP). Verbal memory after epilepsy surgery in childhood. Epilepsy Res 2013; 107 (1, 2): 146-155
    CrossrefPubMedGoogle Scholar
  • 26 Meekes J, Braams OB, Braun KP. , et al. Visual memory after epilepsy surgery in children: a standardized regression-based analysis of group and individual outcomes. Epilepsy Behav 2014; 36: 57-67
    CrossrefPubMedGoogle Scholar
  • 27 Meekes J, van Schooneveld MM, Braams OB. , et al. Parental education predicts change in intelligence quotient after childhood epilepsy surgery. Epilepsia 2015; 56 (04) 599-607
    CrossrefPubMedGoogle Scholar
  • 28 Sibilia V, Barba C, Metitieri T. , et al. Cognitive outcome after epilepsy surgery in children: A controlled longitudinal study. Epilepsy Behav 2017; 73: 23-30
    CrossrefPubMedGoogle Scholar
  • 29 Boshuisen K, van Schooneveld MM, Uiterwaal CS. , et al; Time To Stop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015; 78 (01) 104-114
    CrossrefPubMedGoogle Scholar
  • 30 Bulteau C, Grosmaitre C, Save-Pédebos J. , et al. Language recovery after left hemispherotomy for Rasmussen encephalitis. Epilepsy Behav 2015; 53: 51-57
    CrossrefPubMedGoogle Scholar
  • 31 Chen HH, Chen C, Hung SC. , et al. Cognitive and epilepsy outcomes after epilepsy surgery caused by focal cortical dysplasia in children: early intervention maybe better. Childs Nerv Syst 2014; 30 (11) 1885-1895
    CrossrefPubMedGoogle Scholar
  • 32 Freri E, Matricardi S, Gozzo F, Cossu M, Granata T, Tassi L. Perisylvian, including insular, childhood epilepsy: presurgical workup and surgical outcome. Epilepsia 2017; 58 (08) 1360-1369
    CrossrefPubMedGoogle Scholar
  • 33 Ghatan S, McGoldrick P, Palmese C. , et al. Surgical management of medically refractory epilepsy due to early childhood stroke. J Neurosurg Pediatr 2014; 14 (01) 58-67
    CrossrefPubMedGoogle Scholar
  • 34 Granata T, Matricardi S, Ragona F. , et al. Hemispherotomy in Rasmussen encephalitis: long-term outcome in an Italian series of 16 patients. Epilepsy Res 2014; 108 (06) 1106-1119
    CrossrefPubMedGoogle Scholar
  • 35 Gröppel G, Dorfer C, Mühlebner-Fahrngruber A. , et al. Improvement of language development after successful hemispherotomy. Seizure 2015; 30: 70-75
    CrossrefPubMedGoogle Scholar
  • 36 Hoffman CE, Ochi A, Snead III OC. , et al. Rasmussen's encephalitis: advances in management and patient outcomes. Childs Nerv Syst 2016; 32 (04) 629-640
    CrossrefPubMedGoogle Scholar
  • 37 Kwon HE, Eom S, Kang HC. , et al. Surgical treatment of pediatric focal cortical dysplasia: clinical spectrum and surgical outcome. Neurology 2016; 87 (09) 945-951
    CrossrefPubMedGoogle Scholar
  • 38 Kimura N, Takahashi Y, Shigematsu H. , et al. Developmental outcome after surgery in focal cortical dysplasia patients with early-onset epilepsy. Epilepsy Res 2014; 108 (10) 1845-1852
    CrossrefPubMedGoogle Scholar
  • 39 Lah S, Smith ML. Verbal memory and literacy outcomes one year after pediatric temporal lobectomy: a retrospective cohort study. Epilepsy Behav 2015; 44: 225-233
    CrossrefPubMedGoogle Scholar
  • 40 Law N, Benifla M, Rutka J, Smith ML. Verbal memory after temporal lobe epilepsy surgery in children: do only mesial structures matter? . Epilepsia 2017; 58 (02) 291-299
    CrossrefPubMedGoogle Scholar
  • 41 Lee YJ, Kang HC, Kim HD. , et al. Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy. Pediatr Neurol 2015; 52 (01) 88-93
    CrossrefPubMedGoogle Scholar
  • 42 Lee YJ, Kim EH, Yum MS, Lee JK, Hong S, Ko TS. Long-term outcomes of hemispheric disconnection in pediatric patients with intractable epilepsy. J Clin Neurol 2014; 10 (02) 101-107
    CrossrefPubMedGoogle Scholar
  • 43 Martin R, Cirino P, Hiscock M, Schultz R, Collins R, Chapieski L. Risks and benefits of epilepsy surgery in a pediatric population: consequences for memory and academic skills. Epilepsy Behav 2016; 62: 189-196
    CrossrefPubMedGoogle Scholar
  • 44 Oitment C, Vriezen E, Smith ML. Everyday memory in children after resective epilepsy surgery. Epilepsy Behav 2013; 28 (02) 141-146
    CrossrefPubMedGoogle Scholar
  • 45 Ramantani G, Kadish NE, Anastasopoulos C. , et al. Epilepsy surgery for glioneuronal tumors in childhood: avoid loss of time. Neurosurgery 2014; 74 (06) 648-657 , discussion 657
    CrossrefPubMedGoogle Scholar
  • 46 Ramantani G, Kadish NE, Mayer H. , et al. Frontal lobe epilepsy surgery in childhood and adolescence: predictors of long-term seizure freedom, overall cognitive functioning and adaptive functioning. Neurosurgery 2018; 83 (01) 93-103
    CrossrefPubMedGoogle Scholar
  • 47 Ramantani G, Kadish NE, Strobl K. , et al. Seizure and cognitive outcomes of epilepsy surgery in infancy and early childhood. Eur J Paediatr Neurol 2013; 17 (05) 498-506
    CrossrefPubMedGoogle Scholar
  • 48 Ramírez-Molina JL, Di Giacomo R, Mariani V. , et al. Surgical outcomes in two different age groups with Focal Cortical Dysplasia type II: any real difference? . Epilepsy Behav 2017; 70 (Pt A): 45-49
    CrossrefPubMedGoogle Scholar
  • 49 van Schooneveld MMJ, Braun KP, van Rijen PC, van Nieuwenhuizen O, Jennekens-Schinkel A. The spectrum of long-term cognitive and functional outcome after hemispherectomy in childhood. Eur J Paediatr Neurol 2016; 20 (03) 376-384
    CrossrefPubMedGoogle Scholar
  • 50 Sierra-Marcos A, Fournier-Del Castillo MC, Álvarez-Linera J, Budke M, García-Fernández M, Pérez-Jiménez MA. Functional surgery in pediatric drug-resistant posterior cortex epilepsy: electro-clinical findings, cognitive and seizure outcome. Seizure 2017; 52: 46-52
    CrossrefPubMedGoogle Scholar
  • 51 Shurtleff HA, Barry D, Firman T. , et al. Impact of epilepsy surgery on development of preschool children: identification of a cohort likely to benefit from early intervention. J Neurosurg Pediatr 2015; 16 (04) 383-392
    CrossrefPubMedGoogle Scholar
  • 52 Skirrow C, Cross JH, Harrison S. , et al. Temporal lobe surgery in childhood and neuroanatomical predictors of long-term declarative memory outcome. Brain 2015; 138 (Pt 1): 80-93
    CrossrefPubMedGoogle Scholar
  • 53 Villarejo-Ortega F, García-Fernández M, Fournier-Del Castillo C. , et al. Seizure and developmental outcomes after hemispherectomy in children and adolescents with intractable epilepsy. Childs Nerv Syst 2013; 29 (03) 475-488
    CrossrefPubMedGoogle Scholar
  • 54 Lah S. Neuropsychological outcome following focal cortical removal for intractable epilepsy in children. Epilepsy Behav 2004; 5 (06) 804-817
    CrossrefPubMedGoogle Scholar
  • 55 Reilly C, Atkinson P, Das KB. , et al. Cognition in school-aged children with “active” epilepsy: a population-based study. J Clin Exp Neuropsychol 2015; 37 (04) 429-438
    CrossrefPubMedGoogle Scholar
  • 56 van Iterson L, Zijlstra BJ, Augustijn PB, van der Leij A, de Jong PF. Duration of epilepsy and cognitive development in children: a longitudinal study. Neuropsychology 2014; 28 (02) 212-221
    CrossrefPubMedGoogle Scholar
  • 57 Poropat AE. A meta-analysis of adult-rated child personality and academic performance in primary education. Br J Educ Psychol 2014; 84 (Pt 2): 239-252
    CrossrefPubMedGoogle Scholar
  • 58 Schraegle WA, Nussbaum NL, Titus JB. Executive dysfunction and depression in pediatric temporal lobe epilepsy: the contribution of hippocampal sclerosis and psychosocial factors. J Int Neuropsychol Soc 2018; 24 (06) 606-616
    CrossrefPubMedGoogle Scholar
  • 59 Farrace D, Tommasi M, Casadio C, Verrotti A. Parenting stress evaluation and behavioral syndromes in a group of pediatric patients with epilepsy. Epilepsy Behav 2013; 29 (01) 222-227
    CrossrefPubMedGoogle Scholar
  • 60 Braams O, Meekes J, Braun K. , et al. Parenting stress does not normalize after child's epilepsy surgery. Epilepsy Behav 2015; 42: 147-152
    CrossrefPubMedGoogle Scholar
  • 61 World Health Organization. International Classification of Functioning, Disability and Health: Children & Youth version (ICF-CY). Geneva, Switzerland: World Health Organization; 2007
    Google Scholar