Parafalcine Chondrosarcoma: Unusual Localization for a Classic Variant

Primary intracranial chondrosarcoma is an extremely rare malignant tumor of the central nervous system, which accounts for less than 0.16% of all primary intracranial tumors.[1] Most are located at the skull base, where they are thought to arise from cartilage of the synchondroses. Less commonly, chondroid tumors arise from the choroid plexus, dura mater, or brain parenchyma. Histologically, three variants of chondrosarcoma have been described: myxoid, mesenchymal, and classic chondrosarcoma. Since the first description of intracranial chondrosarcoma by Mott in 1899, only 53 cases chondrosarcomas arising above the skull base have been reported and most of these are of the highly malignant mesenchymal variant.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] Only 12 cases of classic variant chondrosarcomas have been reported in the falcine/parafalcine location ([Table 1]).[2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] The authors report one more case of classic chondrosarcoma arising in such an unusual location.

Table 1 Clinical characteristics of all the 12 cases including our case of classic variant of extraskeletal chondrosarcomas at falx and parasagittal locations

Year	Article	Age/sex	Location	Pathology	Follow–up	Recurrence	Alive/dead
Adapted from Krishnan et al.[12]
1978	Alvira and McLaurin[2]	21/F	Left frontal subdural and interhemispheric	Low–grade chondrosarcoma	No follow–up	No follow–up	No follow–up
1985	Cybulski et al[3]	58/M	Anterior falx	Low–grade chondrosarcoma	18 mo	No	Alive
1998	Gerszten et al[4]	12/F	Falx	Low–grade chondrosarcoma	9 mo	No	Alive
1998	Forbes and Eljamel[5]	19/F	Anterior falx	Nonmesenchymal chondrosarcoma	2 y	No	Alive
2001	Oruckaptan et al[6]	56/F	Anterior falx	Low–grade classic chondrosarcoma	3 y	No	Alive
2003	Kothary et al[7]	28/F	Frontoparietal parasagittal	Classic chondrosarcoma	No follow–up	No follow–up	No follow–up
2005	Tosaka et al[8]	18/F	Frontal parasagittal	Low–grade chondrosarcoma	No follow–up	No follow–up	No follow–up
2008	Kathiravel and Finnis[9]	32/F	Left Frontoparietal parasagittal	Classic chondrosarcoma	15 mo	No	Alive
2009	Boccardo et al[10]	32/F	Anterior falx	Low–grade chondrosarcoma	NA	NA	NA
2009	Güneş et al[1]	25/M	Posterior falx	Low–grade chondrosarcoma	No follow–up	No follow–up	No follow–up
2011	Krishnan et al[12]	23/F	Anterior falx	Grade I classic chondrosarcoma	16 mo	No	Alive
2011	Krishnan et al[12]	19/M	Right frontal parasagittal	Grade I classic chondrosarcoma	12 mo	No	Alive
2018	Present case	30/F	Left parieto–posterior parafalcine	Grade I classic chondrosarcoma	12 mo	No	Alive

• References

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