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J Neurol Surg B Skull Base 2019; 80(04): 416-423
DOI: 10.1055/s-0038-1675592
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base

Kevin J. Choi
1   Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, North Carolina, United States
,
Feras Y. Ackall
1   Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, North Carolina, United States
,
Tracy Truong
2   Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States
,
Tracy Z. Cheng
1   Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, North Carolina, United States
3   Duke University School of Medicine, Durham, North Carolina, United States
,
Maragatha Kuchibhatla
2   Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States
3   Duke University School of Medicine, Durham, North Carolina, United States
,
Ali R. Zomorodi
4   Department of Neurosurgery, Duke University, Durham, North Carolina, United States
,
Patrick J. Codd
4   Department of Neurosurgery, Duke University, Durham, North Carolina, United States
,
Peter E. Fecci
4   Department of Neurosurgery, Duke University, Durham, North Carolina, United States
,
Ralph Abi Hachem
1   Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, North Carolina, United States
4   Department of Neurosurgery, Duke University, Durham, North Carolina, United States
,
David W. Jang
1   Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University, Durham, North Carolina, United States
4   Department of Neurosurgery, Duke University, Durham, North Carolina, United States
› Author Affiliations
Further Information

Publication History

20 March 2018

30 September 2018

Publication Date:
12 November 2018 (online)

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Abstract

Introduction Endoscopic endonasal skull base surgery (EESBS) leads to significant alterations in sinonasal anatomy and physiology. However, there is limited data available on quality of life (QOL) outcomes following EESBS.

Methods A retrospective review of patients undergoing EESBS from January 2014 to April 2017 was performed. Records were reviewed for clinical history, operative details, and 22-item Sinonasal Outcomes Test (SNOT-22) scores. Unadjusted and adjusted linear regression models were utilized to compare change in SNOT-22 scores from baseline in patients who underwent a simple sella approach (SA) or an extended beyond sella approach (BSA).

Results A total of 108 patients were in the SA group, while 61 patients were in the BSA group. SNOT-22 scores were available at baseline and 3 months for 84 patients, while 6-month scores were available for 49 patients. SNOT-22 scores for all patients were not significantly different at 3 months (p = 0.40) or at 6 months (p = 0.58). Unadjusted linear regression model did not show an association between the type of approach and change in SNOT-22 score at 3 months (p = 0.07) and 6 months (p = 0.28). Adjusted regression model showed a significant decrease in SNOT-22 scores at 3 months (p = 0.04) for the BSA group, but there was no significant change in SNOT-22 score at 6 months (p = 0.22).

Conclusion Patients undergoing EESBS had no significant change in outcomes at 3 and 6 months. A more extensive BSA was not associated with worse QOL outcomes as measured by SNOT-22.

Keywords

quality of life - SNOT-22 - Sinonasal Outcomes Test - skull base surgery - endoscopic surgery - pituitary

Note

Oral presentation at the 2018 North American Skull Base Society Annual Meeting, Coronado, California, United States, February 17, 2018.


Financial Disclosure

No relevant disclosure.